5-Aminosalicylic Acid attenuates allergen-induced airway inflammation and oxidative stress in asthma

Abstract Pro-inflammatory cytokines regulate the magnitude of allergic reactions during asthma. Tumor necrosis factor – alpha (TNF-α), interleukin-6 (IL-6) and interleukin-13 (IL-13) play a crucial role in aggravating the inflammatory conditions during allergic asthma. In addition, oxidative stress...

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Published in:	Pulmonary pharmacology & therapeutics Vol. 29; no. 2; pp. 209 - 216
Main Authors:	Raju, K. Rama Satyanarayana, Kumar, M.N. Sathish, Gupta, Saurabh, Naga, Srinivas T, Shankar, Jaya K, Murthy, Vishakantha, Madhunapanthula, Subba Rao V, Mulukutla, Shashank, Ambhore, Nilesh S, Tummala, Shashank, Vishnuvarthan, V.J, Azam, Afzal, Elango, Kannan
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-12-2014
Subjects:	5-Aminosalicylic acid Allergic asthma Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Asthma - chemically induced Asthma - drug therapy Bronchoalveolar Lavage Fluid - chemistry Inflammation Inflammation - drug therapy Interleukin-13 - analysis Interleukin-6 - analysis Lung - chemistry Male Malondialdehyde - analysis Medical Education Mesalamine - therapeutic use Mice, Inbred BALB C Nitrates - analysis Nitrites - analysis Ovalbumin - pharmacology Oxidative stress Oxidative Stress - drug effects Peroxidase - analysis Proinflammatory cytokines Pulmonary/Respiratory Tumor Necrosis Factor-alpha - analysis Allergic asthma Oxidative stress 5-Aminosalicylic acid Inflammation Proinflammatory cytokines
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Summary:	Abstract Pro-inflammatory cytokines regulate the magnitude of allergic reactions during asthma. Tumor necrosis factor – alpha (TNF-α), interleukin-6 (IL-6) and interleukin-13 (IL-13) play a crucial role in aggravating the inflammatory conditions during allergic asthma. In addition, oxidative stress contributes to the pathogenesis of asthma by altering the physiological condition resulting in the development of status asthmaticus . Anti-inflammatory corticosteroids are being widely used for treating allergic asthma. In the present study 5-aminosalicylic acid (5-ASA), a salicylic acid derivative, was evaluated, in vivo for its potential to suppress TNF-α, IL-6 and IL-13 using ovalbumin (OVA) induced allergic asthma in Balb/C mice. Oral administration of 65, 130 and 195 mg/kg 5-ASA significantly reduced the OVA induced total and differential leucocyte count, TNF-α, IL-6, IL-13, nitrite, nitrate, MDA, MPO and TPL levels in the lung lavage samples. Collectively, these findings suggest that 5-ASA is a potent immunomodulator and suppresses key Th2 cytokines production and oxidative stress in OVA-induced asthma.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1094-5539 1522-9629
DOI:	10.1016/j.pupt.2014.07.007