Minimal handgrip force is needed for transcutaneous electrical stimulation to improve hand functions of patients with severe spinal cord injury

Minimal handgrip force is needed for transcutaneous electrical stimulation to improve hand functions of patients with severe spinal cord injury

Spinal cord stimulation enhanced restoration of motor function following spinal cord injury (SCI) in unblinded studies. To determine whether training combined with transcutaneous electrical spinal cord stimulation (tSCS), with or without systemic serotonergic treatment with buspirone (busp), could i...

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Bibliographic Details
Published in:Scientific reports Vol. 12; no. 1; pp. 7733 - 13
Main Authors: Huang, Ruyi, Nikooyan, Ali A., Moore, Lisa D., Zdunowski, Sharon, Morikawa, Erika, Sierro, Tiffany, Sayenko, Dimitry, Gad, Parag, Homsey, Tali, Le, Timothy, Madhavan, Meghna A., Abdelshahid, Marina, Abdelshahid, Martina, Zhou, Yan, Nuwer, Mark R., Sarrafzadeh, Majid, Edgerton, V. Reggie, Leiter, James C., Lu, Daniel C.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 11-05-2022
Nature Publishing Group
Nature Portfolio
Subjects:
631/378
631/378/2632
631/378/2632/1823
Buspirone
Cross-Over Studies
Electrical stimuli
Grasping
Hand Strength
Humanities and Social Sciences
Humans
Motor ability
multidisciplinary
Paralysis
Science
Science (multidisciplinary)
Spinal Cord - physiology
Spinal cord injuries
Spinal Cord Injuries - therapy
Spinal Cord Stimulation
Training
Transcutaneous Electric Nerve Stimulation
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Summary:Spinal cord stimulation enhanced restoration of motor function following spinal cord injury (SCI) in unblinded studies. To determine whether training combined with transcutaneous electrical spinal cord stimulation (tSCS), with or without systemic serotonergic treatment with buspirone (busp), could improve hand function in individuals with severe hand paralysis following SCI, we assessed ten subjects in a double-blind, sham-controlled, crossover study. All treatments—busp, tSCS, and the busp plus tSCS—reduced muscle tone and spasm frequency. Buspirone did not have any discernible impact on grip force or manual dexterity when administered alone or in combination with tSCS. In contrast, grip force, sinusoidal force generation and grip-release rate improved significantly after 6 weeks of tSCS in 5 out of 10 subjects who had residual grip force within the range of 0.1–1.5 N at the baseline evaluation. Improved hand function was sustained in subjects with residual grip force 2–5 months after the tSCS and buspirone treatment. We conclude that tSCS combined with training improves hand strength and manual dexterity in subjects with SCI who have residual grip strength greater than 0.1 N. Buspirone did not significantly improve the hand function nor add to the effect of stimulation.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-11306-5