Search Results - "Madhani, H"

Effectors of a Developmental Mitogen-Activated Protein Kinase Cascade Revealed by Expression Signatures of Signaling Mutants by Madhani, H. D., Galitski, T., Lander, E. S., Fink, G. R.

“…Despite the importance of mitogen-activated protein kinase (MAPK) signaling in eukaryotic biology, the mechanisms by which signaling yields phenotypic changes…”
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Conserved Histone Variant H2A.Z Protects Euchromatin from the Ectopic Spread of Silent Heterochromatin by Meneghini, Marc D., Wu, Michelle, Madhani, Hiten D.

“…Boundary elements hinder the spread of heterochromatin, yet these sites do not fully account for the preservation of adjacent euchromatin. Histone variant…”
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Combinatorial control required for the specificity of yeast MAPK signaling by Madhani, H.D. (Whitehead Institute for Biomedical Research, Cambridge, MA.), Fink, G.R

“…In yeast, an overlapping set of mitogen-activated protein kinase (MAPK) signaling components controls mating, haploid invasion, and pseudohyphal development…”
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Application of successive interference cancellation to the GPS pseudolite near-far problem by Madhani, P.H., Axelrad, P., Krumvieda, K., Thomas, J.

“…Ground-based transmitters called pseudolites have been proposed to augment the basic Global Positioning System (GPS) in environments where satellite visibility…”
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The riddle of MAP kinase signaling specificity by Madhani, Hiten D, Fink, Gerald R

“…Cells encounter an enormous variety of signals in their environments and must respond to each stimulus appropriately with changes in their genetic programs…”
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Principles of MAP kinase signaling specificity in Saccharomyces cerevisiae by Schwartz, Monica A, Madhani, Hiten D

“…Cells respond to a plethora of signals using a limited set of intracellular signal transduction components. Surprisingly, pathways that transduce distinct…”
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A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin by Kobor, Michael S, Venkatasubrahmanyam, Shivkumar, Meneghini, Marc D, Gin, Jennifer W, Jennings, Jennifer L, Link, Andrew J, Madhani, Hiten D, Rine, Jasper

“…The conserved histone variant H2A.Z functions in euchromatin to antagonize the spread of heterochromatin. The mechanism by which histone H2A is replaced by…”
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A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome by Madhani, H D, Guthrie, C

“…Prior to the chemical steps of mRNA splicing, the extensive base-pairing interaction between the U4 and U6 spliceosomal snRNAs is disrupted. Here, we use a…”
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Pheromone-Dependent Destruction of the Tec1 Transcription Factor Is Required for MAP Kinase Signaling Specificity in Yeast by Bao, Marie Z., Schwartz, Monica A., Cantin, Greg T., Yates, John R., Madhani, Hiten D.

“…The yeast MAPK pathways required for mating versus filamentous growth share multiple components yet specify distinct programs. The mating-specific MAPK, Fus3,…”
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MAP Kinases with Distinct Inhibitory Functions Impart Signaling Specificity during Yeast Differentiation by Madhani, Hiten D., Styles, Cora A., Fink, Gerald R.

“…Filamentous invasive growth of S. cerevisiae requires multiple elements of the mitogen-activated protein kinase (MAPK) signaling cascade that are also…”
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The control of filamentous differentiation and virulence in fungi by Madhani, Hiten D, Fink, Gerald R

“…Many members of the fungal kingdom have a distinguishing feature, dimorphism, which is the ability to switch between two morphological forms: a cellular yeast…”
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Randomization-selection analysis of snRNAs in vivo : evidence for a tertiary interaction in the spliceosome by MADHANI, H. D, GUTHRIE, C

“…Putative components of the spliceosomal active site include a bulged helix between U2 and U6 snRNAs (U2-U6 helix I) and the adjacent ACAGAG hexanucleotide in…”
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Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region by Jacks, T, Madhani, H D, Masiarz, F R, Varmus, H E

“…The gag-pol protein of Rous sarcoma virus (RSV), the precursor to the enzymes responsible for reverse transcription and integration, is expressed from two…”
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A Conserved RING Finger Protein Required for Histone H2B Monoubiquitination and Cell Size Control by Hwang, William W., Venkatasubrahmanyam, Shivkumar, Ianculescu, Alexandra G., Tong, Amy, Boone, Charles, Madhani, Hiten D.

“…Monoubiquitination of histone H2B is required for methylation of histone H3 on lysine 4 (K4), a modification associated with active chromatin. The identity of…”
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Dynamic RNA-RNA Interactions in the Spliceosome by Madhani, H D, Guthrie, C

“…The RNA structural aspects of gene splicing are discussed, focusing on the dynamic properties of the spliceosomal apparatus. Substrate interactions and…”
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Interplay of Intrinsic and Extrinsic Signals in Yeast Differentiation by Madhani, H D

“…Madhani discusses the developmental options of Saccharomyces cerevisiae cell types. Haploid a or alpha cells differentiate into a filamentous form in response…”
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Multiple roles for U6 snRNA in the splicing pathway by MADHANI, H. D, BORDONNE, R, GUTHRIE, C

“…U6 is the most highly conserved of the five spliceosomal RNAs. It is associated with U4 by an extensive base-pairing interaction, which is disrupted…”
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Accounting for Specificity in Receptor Tyrosine Kinase Signaling by Madhani, Hiten D.

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Mechanisms that Specify Promoter Nucleosome Location and Identity by Hartley, Paul D., Madhani, Hiten D.

“…The chromatin architecture of eukaryotic gene promoters is generally characterized by a nucleosome-free region (NFR) flanked by at least one H2A.Z variant…”
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Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase by Madhani, H.D, Guthrie, C

“…Pre-mRNA splicing occurs in a large and dynamic ribonucleoprotein complex, the spliceosome. Several protein factors involved in splicing are homologous to a…”
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