Search Results - "Maderdrut, Jerome L"

A structure–function study of PACAP using conformationally restricted analogs: Identification of PAC1 receptor-selective PACAP agonists by Ramos-Álvarez, Irene, Mantey, Samuel A., Nakamura, Taichi, Nuche-Berenguer, Bernardo, Moreno, Paola, Moody, Terry W., Maderdrut, Jerome L., Coy, David H., Jensen, Robert T.

“…•46 PACAP analogs were synthesized with conformationally restricted substitutions.•Their pharmacology (affinity and potency) was determined for VPAC1R, VPAC2R…”
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Pituitary adenylate cyclase-activating polypeptide ameliorates cisplatin-induced acute kidney injury by Li, Min, Balamuthusamy, Saravanan, Khan, Altaf M., Maderdrut, Jerome L., Simon, Eric E., Batuman, Vecihi

“…Cisplatin nephrotoxicity involves DNA damage, proinflammatory responses and apoptosis/necrosis of renal proximal tubular epithelial cells. Pituitary adenylate…”
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Renoprotection by pituitary adenylate cyclase-activating polypeptide in multiple myeloma and other kidney diseases by Li, Min, Maderdrut, Jerome L., Lertora, Juan J.L., Arimura, Akira, Batuman, Vecihi

“…Renal involvement in patients with multiple myeloma complicates their treatment and shortens their life-span. The main renal lesion is a tubulointerstitial…”
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Pituitary Adenylate Cyclase-Activating Polypeptide Prevents Cisplatin-Induced Renal Failure by Li, Min, Balamuthusamy, Saravanan, Khan, Altaf M., Maderdrut, Jerome L., Simon, Eric E., Batuman, Vecihi

“…Cisplatin is widely used for cancer chemotherapy, but nephrotoxicity is a major dose-limiting side effect. Our recent studies in vitro have shown that…”
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The effect of PACAP38 on MyD88-mediated signal transduction in ischemia-/hypoxia-induced acute kidney injury by Li, Min, Khan, Altaf-M, Maderdrut, Jerome L, Simon, Eric E, Batuman, Vecihi

“…toll-like receptor 4 (TLR4) and its adaptor protein MyD88 play an important role in ischemia/reperfusion (I/R) injury in the kidney, and pituitary adenylate…”
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Pituitary adenylate cyclase-activating polypeptide is a potent broad-spectrum antimicrobial peptide: Structure-activity relationships by Starr, Charles G., Maderdrut, Jerome L., He, Jing, Coy, David H., Wimley, William C.

“…•PACAP38 has broad spectrum antimicrobial activity.•Full length agonist and antagonist variants retain antimicrobial activity.•Receptor activation and…”
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Distribution of urocortin-like immunoreactivity in the central nervous system of the frog Rana esculenta by Kozicz, Tamás, Arimura, Akira, Maderdrut, Jerome L., Lázár, Gyula

“…Corticotropin‐releasing factor (CRF), sauvagine, and urotensin I are all members of the so‐called CRF neuropeptide family. Urocortin (Ucn), a 40‐amino‐acid…”
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Pituitary adenylate cyclase-activating polypeptide (PACAP) protects against mitoxantrone-induced cardiac injury in mice by Subramaniam, Venkat, Chuang, Gin, Xia, Huijing, Burn, Brendan, Bradley, Jessica, Maderdrut, Jerome L., Coy, David H., Varner, Kurt J.

“…•Treatment with mitoxantrone once a week caused a dilated cardiomyopathy in mice.•Treatment with mitoxantrone once a week caused a large loss of body weight in…”
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Mo1784 Identification of Selective Agonists for the Hpac1 Receptor by Mantey, Samuel A, Maderdrut, Jerome L, Coy, David, Jensen, Robert T

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Intravenous infusion of pituitary adenylate cyclase-activating polypeptide (PACAP) in a patient with multiple myeloma and myeloma kidney: A case study by Li, Min, Maderdrut, Jerome L., Lertora, Juan J.L., Batuman, Vecihi

“…We have recently shown significant renoprotective effects with the administration of pituitary adenylate cyclase-activating polypeptide (PACAP) in models of…”
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Delayed administration of pituitary adenylate cyclase-activating polypeptide 38 ameliorates renal ischemia/reperfusion injury in mice by modulating Toll-like receptors by Khan, Altaf-M., Li, Min, Abdulnour-Nakhoul, Solange, Maderdrut, Jerome L., Simon, Eric E., Batuman, Vecihi

“…► Bilateral renal ischemia/reperfusion (IR) induced kidney injury in mice. ► IR activated Toll-like receptors (TLRs). ► TLRs induced inflammatory cytokine…”
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Renoprotection With Pituitary Adenylate Cyclase-Activating Polypeptide in Cyclosporine A-Induced Nephrotoxicity by Khan, Altaf-M, Li, Min, Brant, Elizabeth, Maderdrut, Jerome L., Majid, Dewan S.A., Simon, Eric E., Batuman, Vecihi

“…BackgroundAcute and long-term nephrotoxicity is the major dose-limiting factor for cyclosporine A (CsA). We evaluated the protective effects of pituitary…”
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Myeloma light chain-induced renal injury in mice by Khan, Altaf-M, Li, Min, Balamuthusamy, Saravanan, Maderdrut, Jerome L, Simon, Eric E, Batuman, Vecihi

“…We investigated the effects of human light chain (LC) protein-overload in mice kidney to gain further insights into the molecular mechanisms involved in the…”
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Pituitary adenylate cyclase‐activating polypeptide prevents contrast‐induced nephropathy in a novel mouse model by Khan, Altaf‐M., Maderdrut, Jerome L., Li, Min, Toliver, Herman L., Coy, David H., Simon, Eric E., Batuman, Vecihi

“…We determined whether pituitary adenylate cyclase‐activating polypeptide 38 (PACAP38) prevents contrast‐induced nephropathy using human renal proximal tubule…”
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Neuroprotective Effects of PACAP38 in a Rat Model of Transient Focal Ischemia under Various Experimental Conditions by REGLODI, DORA, SOMOGYVARI-VIGH, ANIKO, VIGH, SANDOR, MADERDRUT, JEROME L., ARIMURA, AKIRA

“…: In the study reported here, we investigated the neuroprotective effect of PACAP38 in a rat model of middle cerebral artery occlusion (MCAO) under various…”
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Filament size influences temperature changes and brain damage following middle cerebral artery occlusion in rats by ABRAHAM, Hajnalka, SOMOGYVARI-VIGH, Aniko, MADERDRUT, Jerome L, VIGH, Sandor, ARIMURA, Akira

“…Postischemic spontaneous hyperthermia as a complication of occlusion of the middle cerebral artery with an intraluminal filament has been observed by some…”
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Distribution of melanin-concentrating hormone-like immunoreactivity in the central nervous system of Rana esculenta by Lázár, Gyula, Maderdrut, Jerome L, Merchenthaler, Istvan

“…The distribution of salmon and rat melanin-concentrating hormone (MCH)-like and neuropeptide glutamate-isoleucine (NEI)-like immunoreactivity in the brain and…”
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In situ hybridization histochemical localization of prodynorphin messenger RNA in the central nervous system of the rat by Merchenthaler, István, Maderdrut, Jerome L., Cianchetta, Paul, Shughrue, Paul, Bronstein, David

“…The distribution of preprodynorphin messenger RNA‐containing perikarya in the central nervous system of the rat was determined with in situ hybridization…”
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Rapidly activated microglial cells in the preoptic area may play a role in the generation of hyperthermia following occlusion of the middle cerebral artery in the rat by ABRAHAM, Hajnalka, SOMOGYVARI-VIGH, Aniko, MADERDRUT, Jerome L, VIGH, Sandor, ARIMURA, Akira

“…Postischemic hyperthermia occurs after the occlusion of the middle cerebral artery (MCAO) with an intraluminal filament in rats. The cause of hyperthermia is…”
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Distribution of proneuropeptide Y-derived peptides in the brain of Rana esculenta and Xenopus laevis by Lázár, G, Maderdrut, J L, Trasti, S L, Liposits, Z, Tóth, P, Kozicz, T, Merchenthaler, I

“…The distribution of proneuropeptide Y-containing perikarya and nerve fibers in the brain of Rana esculenta and Xenopus laevis was determined with antisera…”
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