Search Results - "Madeddu, Paolo"

Looking at a baby's heart through the lens of the mother's blood by Madeddu, Paolo

“…Congenital heart disease (CHD) comprises several cardiovascular abnormalities existing from birth. Cardiac defects range from minor asymptomatic lesions to…”
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Defective Cardiomyocyte Maturation in the Congenitally Hypoplastic Right Ventricle: A Wrong Molecular Trajectory Leading to Heart Failure? by Madeddu, Paolo

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Current Strategies for the Manufacture of Small Size Tissue Engineering Vascular Grafts by Carrabba, Michele, Madeddu, Paolo

“…Occlusive arterial disease, including coronary heart disease (CHD) and peripheral arterial disease (PAD), is the main cause of death, with an annual mortality…”
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Concise Review: The Regenerative Journey of Pericytes Toward Clinical Translation by Cathery, William, Faulkner, Ashton, Maselli, Davide, Madeddu, Paolo

“…Coronary artery disease (CAD) is the single leading cause of death worldwide. Advances in treatment and management have significantly improved patient…”
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Impaired Regeneration Contributes to Poor Outcomes in Diabetic Peripheral Artery Disease by Fadini, Gian Paolo, Spinetti, Gaia, Santopaolo, Marianna, Madeddu, Paolo

“…Diabetes mellitus increases the risk and accelerates the course of peripheral artery disease, making patients more susceptible to ischemic events and…”
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Cardiovascular complications of COVID-19: evidence, misconceptions, and new opportunities by Madeddu, Paolo

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Shifting to a circular approach in publishing research data: new opportunities to develop and promote ideas and curricula in vascular biology by Madeddu, Paolo

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Angiogenesis in Tissue Engineering: As Nature Intended? by Mastrullo, Valeria, Cathery, William, Velliou, Eirini, Madeddu, Paolo, Campagnolo, Paola

“…Despite the steady increase in the number of studies focusing on the development of tissue engineered constructs, solutions delivered to the clinic are still…”
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Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart by Avolio, Elisa, Katare, Rajesh, Thomas, Anita C, Caporali, Andrea, Schwenke, Daryl, Carrabba, Michele, Meloni, Marco, Caputo, Massimo, Madeddu, Paolo

“…Pericytes (PCs) are abundant yet remain the most enigmatic and ill-defined cell population in the heart. Here, we investigated whether PCs can be reprogrammed…”
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Why is a new journal dedicated to vascular biology required? by Madeddu, Paolo

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Concise Review: Diabetes, the Bone Marrow Niche, and Impaired Vascular Regeneration by Fadini, Gian Paolo, Ferraro, Francesca, Quaini, Federico, Asahara, Takayuki, Madeddu, Paolo

“…This review examines the physiological and molecular bone marrow abnormalities associated with diabetes and discusses how bone marrow dysfunction represents a…”
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Transplantation of Human Pericyte Progenitor Cells Improves the Repair of Infarcted Heart Through Activation of an Angiogenic Program Involving Micro-RNA-132 by Katare, Rajesh, Riu, Federica, Mitchell, Kathryn, Gubernator, Miriam, Campagnolo, Paola, Cui, Yuxin, Fortunato, Orazio, Avolio, Elisa, Cesselli, Daniela, Beltrami, Antonio Paolo, Angelini, Gianni, Emanueli, Costanza, Madeddu, Paolo

“…RATIONALE:Pericytes are key regulators of vascular maturation, but their value for cardiac repair remains unknown. OBJECTIVE:We investigated the therapeutic…”
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Diabetes Stimulates Osteoclastogenesis by Acidosis-Induced Activation of Transient Receptor Potential Cation Channels by Reni, Carlotta, Mangialardi, Giuseppe, Meloni, Marco, Madeddu, Paolo

“…Patients with type 1 diabetes have lower bone mineral density and higher risk of fractures. The role of osteoblasts in diabetes-related osteoporosis is well…”
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Therapeutic angiogenesis and vasculogenesis for tissue regeneration by Madeddu, Paolo

“…Therapeutic angiogenesis/vasculogenesis holds promise for the cure of ischaemic disease. The approach postulates the manipulation of spontaneous healing…”
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Deregulation of microRNA-503 Contributes to Diabetes Mellitus-Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia by CAPORALI, Andrea, MELONI, Marco, AGAMI, Reuven, LE SAGE, Carlos, CONDORELLI, Gianluigi, MADEDDU, Paolo, MARTELLI, Fabio, EMANUELI, Costanza, VÖLLENKLE, Christine, BONCI, Desiree, SALA-NEWBY, Graciela B, ADDIS, Roberta, SPINETTI, Gaia, LOSA, Sergio, MASSON, Rachel, BAKER, Andrew H

“…Diabetes mellitus impairs endothelial cell (EC) function and postischemic reparative neovascularization by molecular mechanisms that are not fully understood…”
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Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus by Faulkner, Ashton, Tamiato, Anita, Cathery, William, Rampin, Andrea, Caravaggi, Carlo Maria, Jover, Eva, Allen, Steve, Mellor, Harry, Hauton, David, Heather, Lisa C., Spinetti, Gaia, Madeddu, Paolo

“…Aims/hypothesis Treatment of vascular complications of diabetes remains inadequate. We reported that muscle pericytes (MPs) from limb muscles of vascular…”
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Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice by Qiu, Yan, Buffonge, Stanley, Ramnath, Raina, Jenner, Sophie, Fawaz, Sarah, Arkill, Kenton P., Neal, Chris, Verkade, Paul, White, Stephen J., Hezzell, Melanie, Salmon, Andrew H. J., Suleiman, M.-Saadeh, Welsh, Gavin I., Foster, Rebecca R., Madeddu, Paolo, Satchell, Simon C.

“…Aims/hypothesis Diabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction, which…”
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Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38+ macrophages and NAD+ decline by Ciaglia, Elena, Lopardo, Valentina, Montella, Francesco, Carrizzo, Albino, Di Pietro, Paola, Malavolta, Marco, Giacconi, Robertina, Orlando, Fiorenza, Cattaneo, Monica, Madeddu, Paolo, Vecchione, Carmine, Puca, Annibale Alessandro

“…As we age, our body experiences chronic, systemic inflammation contributing to the morbidity and mortality of the elderly. The senescent immune system has been…”
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Combined Intramyocardial Delivery of Human Pericytes and Cardiac Stem Cells Additively Improves the Healing of Mouse Infarcted Hearts Through Stimulation of Vascular and Muscular Repair by Avolio, Elisa, Meloni, Marco, Spencer, Helen L, Riu, Federica, Katare, Rajesh, Mangialardi, Giuseppe, Oikawa, Atsuhiko, Rodriguez-Arabaolaza, Iker, Dang, Zexu, Mitchell, Kathryn, Reni, Carlotta, Alvino, Valeria V, Rowlinson, Jonathan, Livi, Ugolini, Cesselli, Daniela, Angelini, Gianni, Emanueli, Costanza, Beltrami, Antonio P, Madeddu, Paolo

“…RATIONALE:Optimization of cell therapy for cardiac repair may require the association of different cell populations with complementary activities…”
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Editorial: Insights in cardiovascular biologics and regenerative medicine: 2022 by Madeddu, Paolo, Huang, Ngan F.

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