Search Results - "Maddox, Paul S."
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PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila
Published in The Journal of cell biology (03-12-2018)“…As a dividing cell exits mitosis and daughter cells enter interphase, many proteins must be dephosphorylated. The protein phosphatase 2A (PP2A) with its B55…”
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LITE microscopy: Tilted light-sheet excitation of model organisms offers high resolution and low photobleaching
Published in The Journal of cell biology (07-05-2018)“…Fluorescence microscopy is a powerful approach for studying subcellular dynamics at high spatiotemporal resolution; however, conventional fluorescence…”
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Functional Genomics Identifies a Myb Domain-Containing Protein Family Required for Assembly of CENP-A Chromatin
Published in The Journal of cell biology (12-03-2007)“…Nucleosomes containing the centromere-specific histone H3 variant centromere protein A (CENP-A) create the chromatin foundation for kinetochore assembly. To…”
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Mitotic chromosome length scales in response to both cell and nuclear size
Published in The Journal of cell biology (08-06-2015)“…Multicellular development requires that cells reduce in size as a result of consecutive cell divisions without increase in embryo volume. To maintain cellular…”
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CENP-A: the key player behind centromere identity, propagation, and kinetochore assembly
Published in Chromosoma (01-12-2012)“…Chromosome segregation is the one of the great problems in biology with complexities spanning from biophysics and polymer dynamics to epigenetics. Here, we…”
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DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation
Published in PLoS genetics (14-04-2017)“…Under replete growth conditions, abundant nutrient uptake leads to the systemic activation of insulin/IGF-1 signalling (IIS) and the promotion of stem cell…”
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Octameric CENP-A Nucleosomes Are Present at Human Centromeres throughout the Cell Cycle
Published in Current biology (06-05-2013)“…The presence of a single centromere on each chromosome that signals formation of a mitotic kinetochore is central to accurate chromosome segregation [1]. The…”
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Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing
Published in PLoS genetics (14-10-2019)“…During meiosis, each chromosome must selectively pair and synapse with its own unique homolog to enable crossover formation and subsequent segregation. How…”
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A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A
Published in Nature cell biology (01-12-2010)“…The histone H3 variant CENP-A defines centromeric chromatin, but it is not known how it is maintained at these loci. The CENP-A licensing factor HsKNL2, the…”
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Evi5 promotes collective cell migration through its Rab-GAP activity
Published in The Journal of cell biology (09-07-2012)“…Membrane trafficking has well-defined roles during cell migration. However, its regulation is poorly characterized. In this paper, we describe the first screen…”
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Investigating the Regulation of Stem and Progenitor Cell Mitotic Progression by In Situ Imaging
Published in Current biology (04-05-2015)“…Genome stability relies upon efficacious chromosome congression and regulation by the spindle assembly checkpoint (SAC). The study of these fundamental mitotic…”
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Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis
Published in Nature cell biology (01-12-2005)“…Two distinct chromosome architectures are prevalent among eukaryotes: monocentric, in which localized centromeres restrict kinetochore assembly to a single…”
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Model-based trajectory classification of anchored molecular motor-biopolymer interactions
Published in Biophysical reports (13-12-2023)“…During zygotic mitosis in many species, forces generated at the cell cortex are required for the separation and migration of paternally provided centrosomes,…”
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Live imaging looks deeper
Published in eLife (04-09-2017)“…Iodixanol provides an easy and affordable solution to a problem that has limited resolution and brightness when imaging living samples…”
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A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex
Published in Genes & development (01-09-2008)“…Chromosome segregation requires stable bipolar attachments of spindle microtubules to kinetochores. The dynein/dynactin motor complex localizes transiently to…”
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Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle
Published in The Journal of cell biology (25-08-2008)“…Continuous poleward movement of tubulin is a hallmark of metaphase spindle dynamics in higher eukaryotic cells and is essential for stable spindle architecture…”
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In Situ Imaging in C. elegans Reveals Developmental Regulation of Microtubule Dynamics
Published in Developmental cell (28-04-2014)“…Microtubules (MTs) are cytoskeletal polymers that undergo dynamic instability, the stochastic transition between growth and shrinkage phases. MT dynamics are…”
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Phosphorylation of the Eukaryotic Translation Initiation Factor 4E-Transporter (4E-T) by c-Jun N-Terminal Kinase Promotes Stress-Dependent P-Body Assembly
Published in Molecular and Cellular Biology (01-11-2012)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cell Size: Chromosomes Get Slapped by a Midzone Ruler
Published in Current biology (24-05-2011)“…Spatial and temporal coordination of mitotic events has been generally attributed to the coincidental outcome of increasing cyclin-dependent kinase activity. A…”
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