Search Results - "Maddock, Helen"

Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor by Gharanei, Mayel, Hussain, Afthab, Janneh, Omar, Maddock, Helen

“…Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and…”
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Development of a novel low-order model for atrial function and a study of atrial mechano-electric feedback by Pearce, Nicholas F., Turner, Mark C., Maddock, Helen L., Kim, Eun-jin

“…Numerical models of the cardiovascular system have largely focused on the function of the ventricles, with atrial function often neglected. Furthermore, the…”
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The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection—evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology by Davidson, Sean M., Arjun, Sapna, Basalay, Maryna V., Bell, Robert M., Bromage, Daniel I., Bøtker, Hans Erik, Carr, Richard D., Cunningham, John, Ghosh, Arjun K., Heusch, Gerd, Ibanez, Borja, Kleinbongard, Petra, Lecour, Sandrine, Maddock, Helen, Ovize, Michel, Walker, Malcolm, Wiart, Marlene, Yellon, Derek M.

“…Due to its poor capacity for regeneration, the heart is particularly sensitive to the loss of contractile cardiomyocytes. The onslaught of damage caused by…”
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Anti-cancer Therapy Leads to Increased Cardiovascular Susceptibility to COVID-19 by Lozahic, Caroline, Maddock, Helen, Sandhu, Hardip

“…Anti-cancer treatment regimens can lead to both acute- and long-term myocardial injury due to off-target effects. Besides, cancer patients and survivors are…”
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Predictivity of in vitro non-clinical cardiac contractility assays for inotropic effects in humans — A literature search by Wallis, Rob, Gharanei, Mayel, Maddock, Helen

“…Adverse drug effects on the cardiovascular system are a major cause of compound attrition throughout compound discovery and development. There are many ways by…”
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Caspase Inhibition Via A3 Adenosine Receptors: A New Cardioprotective Mechanism Against Myocardial Infarction by Hussain, Afthab, Gharanei, Ahmed Mayel, Nagra, Aarondeep Singh, Maddock, Helen L.

“…Purpose 2-CL-IB-MECA, (A 3 adenosine receptor agonist)(A 3 AR) mediated cardioprotection is well documented although the associated intracellular signalling…”
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Ipratropium bromide-mediated myocardial injury in in vitro models of myocardial ischaemia/reperfusion by Harvey, Kate L, Hussain, Afthab, Maddock, Helen L

“…Ipratropium bromide, a nonselective muscarinic antagonist, is widely prescribed for the treatment of chronic obstructive pulmonary disease (COPD). Analyses of…”
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Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning? by HAUSENLOY, Derek J, MADDOCK, Helen L, BAXTER, Gary F, YELLON, Derek M

“…We propose that ischemic preconditioning (IPC) and mitochondrial K(ATP) channel activation protect the myocardium by inhibiting mitochondrial permeability…”
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Cardiovascular implications and physical activity in middle-aged and older adults with a history of COVID-19 (CV COVID): a protocol for a randomised controlled trial by Rahman, Mushidur, Russell, Sophie L, Okwose, Nduka C, Hood, Olivia M A, Harwood, Amy E, McGregor, Gordon, Raleigh, Stuart M, Sandhu, Hardip, Roden, Laura C, Maddock, Helen, Banerjee, Prithwish, Jakovljevic, Djordje G

“…The clinical manifestation of COVID-19 is associated with infection and inflammation of the lungs, but there is evidence to suggest that COVID-19 may also…”
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Validity and reliability of short‐term heart‐rate variability from disposable electrocardiography leads by Okwose, Nduka C., Russell, Sophie L., Rahman, Mushidur, Steward, Charles J., Harwood, Amy E., McGregor, Gordon, Ninkovic, Srdjan, Maddock, Helen, Banerjee, Prithwish, Jakovljevic, Djordje G.

“…Background and Aims Single‐use electrocardiography (ECG) leads have been developed to reduce healthcare‐associated infection. This study compared the validity…”
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Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide by MOCANU, Mihaela M, MADDOCK, Helen L, BAXTER, Gary F, LAWRENCE, Christina L, STANDEN, Nicholas B, YELLON, Derek M

“…The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial K(ATP)…”
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The cardioprotective and mitochondrial depolarising properties of exogenous nitric oxide in mouse heart by BELL, Robert M, MADDOCK, Helen L, YELLON, Derek M

“…Nitric oxide (NO) is reported to be both protective and detrimental in models of myocardial ischaemia/reperfusion injury, which may be concentration dependent…”
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Molecular basis of cancer-therapy-induced cardiotoxicity: introducing microRNA biomarkers for early assessment of subclinical myocardial injury by Sandhu, Hardip, Maddock, Helen

“…Development of reliable biomarkers for early clinical assessment of drug-induced cardiotoxicity could allow the detection of subclinical cardiac injury risk in…”
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Myocardial Fatigue: a Mechano-energetic Concept in Heart Failure by Tran, Patrick, Maddock, Helen, Banerjee, Prithwish

“…Purpose of Review This review combines existing mechano-energetic principles to provide a refreshing perspective in heart failure (HF) and examine if the…”
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Protection from myocardial stunning by ischaemia and hypoxia with the adenosine A3 receptor agonist, IB-MECA by MADDOCK, Helen L, GARDNER, Neil M, KHANDOUDI, Nassirah, BRIL, Antoine, BROADLEY, Kenneth J

“…Guinea pig isolated working hearts were exposed to 30-min ischaemia by reducing coronary flow to 10%, followed by reperfusion. Aortic output fell to 4.5+/-4.5%…”
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Myocardial protection from either ischaemic preconditioning or nicorandil is not blocked by gliclazide by MADDOCK, Helen L, SIEDLECKA, Sylvia M, YELLON, Derek M

“…We compared the effects of two sulphonylureas, glibenclamide and gliclazide, on ischaemic preconditioning (IPC) and nicorandil-induced protection in the…”
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Doxorubicin alters G-protein coupled receptor-mediated vasocontraction in rat coronary arteries by Lozahic, Caroline, Maddock, Helen, Wheatley, Mark, Sandhu, Hardip

“…Doxorubicin (Doxo)-associated cardio-and vasotoxicity has been recognised as a serious complication of cancer chemotherapy. The purpose of this novel paper was…”
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Effects of hydrogen sulphide on the isolated perfused rat heart by Maddock, Helen, al-Rajaibi, Hajir, Carson, Ray J., Husayn, Afthab

“…Objectives : Hydrogen supplied has been identified as a gas signaling molecule in the body, and has previously been shown to have vasorelaxant properties. The…”
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Investigating the Cardioprotective Role of Metformin During Sunitinib-Induced Cardiotoxicity by qRT-PCR Profiling of microRNAs Associated with Myocardial Injury by Sandhu, Hardip, Maddock, Helen

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Metformin Protects Against Sunitinib-induced Cardiotoxicity: Investigating the Role of AMPK by Kuburas, Refik, Gharanei, Mayel, Haussmann, Irmgard, Maddock, Helen, Sandhu, Hardip

“…Sunitinib is associated with cardiotoxicity through inhibition of AMP-protein kinase (AMPK) signaling. By contrast, the common antidiabetic agent metformin has…”
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