Search Results - "Maddalo, Gianluca"

Growth of Cyanobacteria Is Constrained by the Abundance of Light and Carbon Assimilation Proteins by Jahn, Michael, Vialas, Vital, Karlsen, Jan, Maddalo, Gianluca, Edfors, Fredrik, Forsström, Björn, Uhlén, Mathias, Käll, Lukas, Hudson, Elton P.

“…Cyanobacteria must balance separate demands for energy generation, carbon assimilation, and biomass synthesis. We used shotgun proteomics to investigate…”
Get full text

Enhanced validation of antibodies for research applications by Edfors, Fredrik, Hober, Andreas, Linderbäck, Klas, Maddalo, Gianluca, Azimi, Alireza, Sivertsson, Åsa, Tegel, Hanna, Hober, Sophia, Szigyarto, Cristina Al-Khalili, Fagerberg, Linn, von Feilitzen, Kalle, Oksvold, Per, Lindskog, Cecilia, Forsström, Björn, Uhlen, Mathias

“…There is a need for standardized validation methods for antibody specificity and selectivity. Recently, five alternative validation pillars were proposed to…”
Get full text

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors by Azimi, Alireza, Caramuta, Stefano, Seashore‐Ludlow, Brinton, Boström, Johan, Robinson, Jonathan L, Edfors, Fredrik, Tuominen, Rainer, Kemper, Kristel, Krijgsman, Oscar, Peeper, Daniel S, Nielsen, Jens, Hansson, Johan, Egyhazi Brage, Suzanne, Altun, Mikael, Uhlen, Mathias, Maddalo, Gianluca

“…Novel therapies are undergoing clinical trials, for example, the Hsp90 inhibitor, XL888, in combination with BRAF inhibitors for the treatment of…”
Get full text

Inhibiting insulin and mTOR signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma by Das, Ishani, Chen, Huiqin, Maddalo, Gianluca, Tuominen, Rainer, Rebecca, Vito W., Herlyn, Meenhard, Hansson, Johan, Davies, Michael A., Egyházi Brage, Suzanne

“…Current treatment modalities for disseminated cutaneous malignant melanoma (CMM) improve survival, however disease progression commonly ensues. In a previous…”
Get full text

ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma by Smit, Marjon A, Maddalo, Gianluca, Greig, Kylie, Raaijmakers, Linsey M, Possik, Patricia A, van Breukelen, Bas, Cappadona, Salvatore, Heck, Albert JR, Altelaar, AF Maarten, Peeper, Daniel S

“…Treatment of BRAF mutant melanomas with specific BRAF inhibitors leads to tumor remission. However, most patients eventually relapse due to drug resistance…”
Get full text

Dual Targeting to Mitochondria and Chloroplasts： Characterization of Thr-tRNA Synthetase Targeting Peptide by Berglund, Anna-Karin, Spånning, Erika, Biverståhl, Henrik, Maddalo, Gianluca, Tellgren-Roth, Christian, Mäler, Lena, Glaser, Elzbieta

“…There is a group of proteins that are encoded by a single gene, expressed as a single precursor protein and dually targeted to both mitochondria and…”
Get full text

Proteomics of Synechocystis sp. PCC 6803 by Pisareva, Tatiana, Shumskaya, Maria, Maddalo, Gianluca, Ilag, Leopold, Norling, Birgitta

“…The cyanobacterial plasma membrane is an essential cell barrier with functions such as the control of taxis, nutrient uptake and secretion. These functions are…”
Get full text

Inflammation and Apolipoproteins Are Potential Biomarkers for Stratification of Cutaneous Melanoma Patients for Immunotherapy and Targeted Therapy by Karlsson, Max J, Costa Svedman, Fernanda, Tebani, Abdellah, Kotol, David, Höiom, Veronica, Fagerberg, Linn, Edfors, Fredrik, Uhlén, Mathias, Egyhazi Brage, Suzanne, Maddalo, Gianluca

“…Malignant cutaneous melanoma is one of the most common cancers in young adults. During the last decade, targeted and immunotherapies have significantly…”
Get full text

Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics by Herr, Patrick, Boström, Johan, Rullman, Eric, Rudd, Sean G., Vesterlund, Mattias, Lehtiö, Janne, Helleday, Thomas, Maddalo, Gianluca, Altun, Mikael

“…The proteome, phospho-proteome, and solubility-fractionated proteome was characterized using a fluorescent cell cycle reporter system (Fucci). Applying…”
Get full text

Screening a Resource of Recombinant Protein Fragments for Targeted Proteomics by Edfors, Fredrik, Forsström, Björn, Vunk, Helian, Kotol, David, Fredolini, Claudia, Maddalo, Gianluca, Svensson, Anne-Sophie, Boström, Tove, Tegel, Hanna, Nilsson, Peter, Schwenk, Jochen M, Uhlen, Mathias

“…The availability of proteomics resources hosting protein and peptide standards, as well as the data describing their analytical performances, will continue to…”
Get full text

Proteomics of Synechocystis sp. PCC 6803. Identification of novel integral plasma membrane proteins by Pisareva, Tatiana, Shumskaya, Maria, Maddalo, Gianluca, Ilag, Leopold, Norling, Birgitta

“…The cyanobacterial plasma membrane is an essential cell barrier with functions such as the control of taxis, nutrient uptake and secretion. These functions are…”
Get full text

Elucidate the underlying molecular mechanisms of the combination treatment effects of Afatinib (EGFR/HER2 inhibitor) and Crizotinib (MET inhibitor) in cutaneous malignant melanoma (CMM) by Das, I., Chen, H., Maddalo, Gianluca, Wilhelm, M., Tuominen, R., Hoiom, V., Hansson, J., Davies, M., Brage, S.

Get full text

A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells by Ressa, Anna, Bosdriesz, Evert, de Ligt, Joep, Mainardi, Sara, Maddalo, Gianluca, Prahallad, Anirudh, Jager, Myrthe, de la Fonteijne, Lisanne, Fitzpatrick, Martin, Groten, Stijn, Altelaar, A.F. Maarten, Bernards, René, Cuppen, Edwin, Wessels, Lodewyk, Heck, Albert J.R.

“…Intrinsic and/or acquired resistance represents one of the great challenges in targeted cancer therapy. A deeper understanding of the molecular biology of…”
Get full text

Identification of Putative Substrates for the Periplasmic Chaperone YfgM in Escherichia coli Using Quantitative Proteomics by Götzke, Hansjörg, Muheim, Claudio, Altelaar, A.F.Maarten, Heck, Albert J.R., Maddalo, Gianluca, Daley, Daniel O.

“…How proteins are trafficked, folded, and assembled into functional units in the cell envelope of Gram-negative bacteria is of significant interest. A number of…”
Get full text

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses by Niklasson, Mia, Maddalo, Gianluca, Sramkova, Zuzana, Mutlu, Ercan, Wee, Shimei, Sekyrova, Petra, Schmidt, Linnéa, Fritz, Nicolas, Dehnisch, Ivar, Kyriatzis, Gregorios, Krafcikova, Michaela, Carson, Brittany B, Feenstra, Jennifer M, Marinescu, Voichita D, Segerman, Anna, Haraldsson, Martin, Gustavsson, Anna-Lena, Hammarström, Lars G J, Jenmalm Jensen, Annika, Uhrbom, Lene, Altelaar, A F Maarten, Linnarsson, Sten, Uhlén, Per, Trantirek, Lukas, Vincent, C Theresa, Nelander, Sven, Enger, Per Øyvind, Andäng, Michael

“…Glioma-initiating cells (GIC) are considered the underlying cause of recurrences of aggressive glioblastomas, replenishing the tumor population and undermining…”
Get full text

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK by Vogel, Celia J., Smit, Marjon A., Maddalo, Gianluca, Possik, Patricia A., Sparidans, Rolf W., van der Burg, Sjoerd H., Verdegaal, Els M., Heck, Albert J. R., Samatar, Ahmed A., Beijnen, Jos H., Altelaar, A. F. Maarten, Peeper, Daniel S.

“…Summary No effective targeted therapy is currently available for NRAS mutant melanoma. Experimental MEK inhibition is rather toxic and has only limited…”
Get full text

Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics by Herr, Patrick, Boström, Johan, Rullman, Eric, Rudd, Sean G, Vesterlund, Mattias, Lehtiö, Janne, Helleday, Thomas, Maddalo, Gianluca, Altun, Mikael

“…The cell cycle is a highly conserved process involving the coordinated separation of a single cell into two daughter cells. To relate transcriptional…”
Get full text

Targeting CDK 2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors by Azimi, Alireza, Caramuta, Stefano, Seashore‐Ludlow, Brinton, Boström, Johan, Robinson, Jonathan L, Edfors, Fredrik, Tuominen, Rainer, Kemper, Kristel, Krijgsman, Oscar, Peeper, Daniel S, Nielsen, Jens, Hansson, Johan, Egyhazi Brage, Suzanne, Altun, Mikael, Uhlen, Mathias, Maddalo, Gianluca

“…Novel therapies are undergoing clinical trials, for example, the Hsp90 inhibitor, XL888, in combination with BRAF inhibitors for the treatment of…”
Get full text

Systematic Analysis of Native Membrane Protein Complexes in Escherichia coli by Maddalo, Gianluca, Stenberg-Bruzell, Filippa, Götzke, Hansjörg, Toddo, Stephen, Björkholm, Patrik, Eriksson, Hanna, Chovanec, Peter, Genevaux, Pierre, Lehtiö, Janne, Ilag, Leopold L, Daley, Daniel O

“…The cell envelope of Escherichia coli is an essential structure that modulates exchanges between the cell and the extra-cellular milieu. Previous proteomic…”
Get full text

Matrix-free thin-layer chromatography/laser desorption ionization mass spectrometry for facile separation and identification of medicinal alkaloids by Shariatgorji, Mohammadreza, Spacil, Zdenek, Maddalo, Gianluca, Cardenas, Lourdes B., Ilag, Leopold L.

“…Quaternary protoberberine alkaloids belong to a pharmaceutically important class of isoquinoline alkaloids associated with bactericidal, fungicidal,…”
Get full text