Search Results - "Maddalena, D J"

Pharmacokinetic parameter prediction from drug structure using artificial neural networks by Turner, Joseph V, Maddalena, Desmond J, Cutler, David J

“…Simple methods for determining the human pharmacokinetics of known and unknown drug-like compounds is a much sought-after goal in the pharmaceutical industry…”
Get full text

Using Artificial Neural Networks To Classify the Activity of Capsaicin and Its Analogues by Hosseini, M, Maddalena, D. J, Spence, I

“…Back-propagation artificial neural networks (ANNs) were trained with parameters derived from different molecular structure representation methods, including…”
Get full text

Bioavailability prediction based on molecular structure for a diverse series of drugs by Turner, Joseph V, Maddalena, Desmond J, Agatonovic-Kustrin, Snezana

“…Radial basis function artificial neural networks and theoretical descriptors were used to develop a quantitative structure-pharmacokinetic relationship for…”
Get full text

Prediction of Receptor Properties and Binding Affinity of Ligands to Benzodiazepine/GABAA Receptors Using Artificial Neural Networks by Maddalena, Desmond J, Johnston, Graham A. R

“…To date the use of artificial neural networks (ANNs) in quantitative structure-activity relationship (QSAR) studies has been primarily concerned in comparing…”
Get full text

Physiological modeling of disposition of potential tumor-imaging radiopharmaceuticals in tumor-bearing mice by Bourne, D W, Jacobs, J J, Awaluddin, A, Maddalena, D J, Wilson, J G, Boyd, R E

“…Radiopharmaceuticals have great potential in the early detection of human tumors. Three potential 99mTc-labeled platinum compounds based on cisplatin have been…”
Get more information

Genotoxicity and cell cycle effects of platinum-based imaging agents in cisplatin-resistant human tumour cells by LEAN, J, PARSONS, P. G, AWALUDDIN, A. B, JACOBS, J. J, MADDALENA, D. J, WILSON, J. G, KHOO, S. K, WARD, C

“…A series of cis-dichloroplatinum(II) 2,3-diaminopropionamide complexes synthesised as potential imaging agents was tested for activity against a human ovarian…”
Get full text

Technetium-99m benzimidazolyl iminodiacetic acid hepatobiliary radiopharmaceuticals: structure biodistribution studies by Hunt, F C, Maddalena, D J, Wilson, J G

“…The biodistribution of fifteen structural variants of the hepatobiliary radiopharmaceutical, technetium-99m benzimidazolyl iminodiacetic acid (BIMIDA) were…”
Get more information

The effect of iron-dextran on the biodistribution of technetium pyrophosphate by Choy, D, Maddalena, D J, Murray, I P

Get more information

The cough or expulsion reflex in the Port Jackson shark, Heterodontus portusjacksoni by Satchell, G H, Maddalena, D J

Get more information

Possible extension of spect cerebral imaging in the investigation of epilepsy using radioiodinated benzodiazepines by Maddalena, D J, Beran, R G, Jenkinson, A, Snowdon, G M

Get more information

Synthesis and characterization of potential tumor scintigraphic agents by Awaluddin, A B, Jacobs, J J, Bourne, D W, Maddalena, D J, Wilson, J G, Boyd, R E

“…Potential tumor imaging radiopharmaceutical agents have been prepared by attaching a cisplatin derivative to a ligand capable of forming a stable complex with…”
Get more information

Zirconium molybdate gel as a generator for technetium-99m--II. High activity generators by Moore, P W, Shying, M E, Sodeau, J M, Evans, J V, Maddalena, D J, Farrington, K H

“…The characteristics of zirconium molybdate gels were described in Part I of this paper. Here it is shown that zirconium molybdate gel, prepared from neutron…”
Get more information

Multiple pharmacokinetic parameter prediction for a series of cephalosporins by Turner, Joseph V, Maddalena, Desmond J, Cutler, David J, Agatonovic-Kustrin, Snezana

“…The goal of quantitative structure-pharmacokinetic relationship analyses is to develop useful models that can predict one or more pharmacokinetic properties of…”
Get more information

Selective descriptor pruning for QSAR/QSPR studies using artificial neural networks by Turner, Joseph V., Cutler, David J., Spence, Ian, Maddalena, Desmond J.

“…Selection of optimal descriptors in quantitative structure–activity–property relationship (QSAR/QSPR) studies has been a perennial problem. Artificial Neural…”
Get full text

Structure-distribution studies on some 99mTc-o-hydroxybenzyliminodiacetic acid complexes by Maddalena, D J, Snowdon, G M, Wilson, J G

“…Biodistributions of a series of thirteen 99mTc-o-hydroxy-benzyliminodiacetic acid complexes were carried out in rats and their hepatobiliary and urinary…”
Get more information

Phenolic aminocarboxylate chelates of 99mTc as hepatobiliary agents by Hunt, F C, Maddalena, D J, Wilson, J G, Bautovich, G J

“…A series of alkyl- and halogen-substituted derivatives of ethylenediamine di[o-hydroxyphenylacetic acid] (EDDHA) and N,N'-bis[2-hydroxybenzyl] ethylenediamine…”
Get more information

Synthesis and biodistribution of 99mTc chelates of acridinyl iminodiacetic acids by Hunt, F C, McLaren, A B, Maddalena, D J, Wilson, J G

Get more information

Biological evaluation of 99mTc labelled cis-platinum containing benzyliminodiacetic acids as potential tumour imaging agents by Jacobs, J J, Maddalena, D J, Wilson, J G, Awaluddin, A, King-Christopher, J, Bourne, D W

“…The synthesis of three new potential tumour-imaging radiopharmaceuticals in which a cis-platin derivative is attached to benzyl iminodiacetic acid, a ligand…”
Get more information