Nomogram for computing the value of similarity factor

Nomogram for computing the value of similarity factor

The objective of present work was to construct nomogram for obtaining a value of similarity factor (f 2 ) by employing the values of number of observations (n) and sum of squared difference of percentage drug dissolved between reference (R) and test (T) products (&#931ni=1(Ri-Ti)2) The steps for...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of pharmaceutical sciences Vol. 76; no. 3; pp. 245 - 251
Main Authors: Gohel, M., Ramkishan, A., Patel, T., Pandya, Radhika, Suthar, Vrunda, Koradia, Hiral, Madat, D., Bariya, Shital, Mehta, Tejal
Format: Journal Article
Language:English
Published: India Medknow Publications 01-05-2014
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Subjects:
Design of experiments
Mathematical functions
Mathematical research
Nomography (Mathematics)
Pharmaceutical industry
Pharmacokinetics
Short Communications
Studies
rearranged similarity function equation
similarity factor
nomogram
Dissolution
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of present work was to construct nomogram for obtaining a value of similarity factor (f 2 ) by employing the values of number of observations (n) and sum of squared difference of percentage drug dissolved between reference (R) and test (T) products (&#931ni=1(Ri-Ti)2) The steps for rearrangement of equation of similarity factor are presented. The values of f 2 were selected in the range of 45 to 100 for 4 to 12 observations (n) for computing the values (&#931ni=1(Ri-Ti)2) of Linear regression analysis was performed between number of observations and (&#931ni=1(Ri-Ti)2) Perfect correlation was observed in each case. Nomogram was constructed and later it was validated by using drug dissolution data from literature and our laboratory. The use of nomogram is recommended during research and development work to investigate effect of formulation or process variables. The nomogram can also be used during change in manufacturing site or change in equipment. It is concluded that the steps for calculation of f 2 can be truncated in the middle (i.e. at the step of calculation of factor (&#931ni=1(Ri-Ti)2) and a decision of similarity/dissimilarity can be taken employing the nomogram.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0250-474X
1998-3743