Search Results - "Madar, Shalom"

‘Cancer associated fibroblasts’ – more than meets the eye by Madar, Shalom, Goldstein, Ido, Rotter, Varda

“…Highlights • ‘CAF’ should be conceived as cell ‘state’ rather than a cell type. • Personalized therapy could be extended to the tumor microenvironment…”
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model by Leshem, Orit, Madar, Shalom, Kogan-Sakin, Ira, Kamer, Iris, Goldstein, Ido, Brosh, Ran, Cohen, Yehudit, Jacob-Hirsch, Jasmine, Ehrlich, Marcelo, Ben-Sasson, Shmuel, Goldfinger, Naomi, Loewenthal, Ron, Gazit, Ephraim, Rotter, Varda, Berger, Raanan

“…Prostate cancer is the most common non-dermatologic malignancy in men in the Western world. Recently, a frequent chromosomal aberration fusing androgen…”
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Differential Influence of Normal and Cancer-Associated Fibroblasts on the Growth of Human Epithelial Cells in an In vitro Cocultivation Model of Prostate Cancer by Paland, Nicole, Kamer, Iris, Kogan-Sakin, Ira, Madar, Shalom, Goldfinger, Naomi, Rotter, Varda

“…The prostate is composed of a number of different cell populations. The interaction between them is crucial for the development and proper function of the…”
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Modulated expression of WFDC1 during carcinogenesis and cellular senescence by Madar, Shalom, Brosh, Ran, Buganim, Yosef, Ezra, Osnat, Goldstein, Ido, Solomon, Hilla, Kogan, Ira, Goldfinger, Naomi, Klocker, Helmut, Rotter, Varda

“…Fibroblasts located adjacent to the tumor [cancer-associated fibroblasts (CAFs)] that constitute a large proportion of the cancer-associated stroma facilitate…”
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p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation by Harris, Curtis C, Ginsberg, Doron, Solomon, Hilla, Shalgi, Reut, Børresen-Dale, Anne-Lise, Goldstein, Ido, Enerly, Espen, Oren, Moshe, Brosh, Ran, Liran, Atar, Rotter, Varda, Landan, Gilad, Madar, Shalom, Korotayev, Katya, Johnsen, Hilde, Pilpel, Yitzhak, Nguyen, Giang Huong, Buganim, Yosef, Goldfinger, Naomi

“…Normal cell growth is governed by a complicated biological system, featuring multiple levels of control, often deregulated in cancers. The role of microRNAs…”
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Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta by Madar, Shalom, Harel, Einav, Goldstein, Ido, Stein, Yan, Kogan-Sakin, Ira, Kamer, Iris, Solomon, Hilla, Dekel, Elya, Tal, Perry, Goldfinger, Naomi, Friedlander, Gilgi, Rotter, Varda

“…Mutations in the p53 tumor suppressor protein are highly frequent in tumors and often endow cells with tumorigenic capacities. We sought to examine a possible…”
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p53 Regulates the Ras Circuit to Inhibit the Expression of a Cancer-Related Gene Signature by Various Molecular Pathways by BUGANIM, Yosef, SOLOMON, Hilla, GORDIN, Maya, RIVLIN, Noa, KOGAN, Ira, BROSH, Ran, SEFADIA-ELAD, Galit, GOLDFINGER, Naomi, SIDRANSKY, David, KLOOG, Yoel, ROTTER, Varda, RAIS, Yoach, KISTNER, Daria, NACHMANY, Ido, BRAIT, Mariana, MADAR, Shalom, GOLDSTEIN, Ido, KALO, Eyal, ADAM, Nitzan

“…In this study, we focus on the analysis of a previously identified cancer-related gene signature (CGS) that underlies the cross talk between the p53 tumor…”
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A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype by Buganim, Yosef, Goldstein, Ido, Lipson, Doron, Milyavsky, Michael, Polak-Charcon, Sylvie, Mardoukh, Corine, Solomon, Hilla, Kalo, Eyal, Madar, Shalom, Brosh, Ran, Perelman, Marina, Navon, Roy, Goldfinger, Naomi, Barshack, Iris, Yakhini, Zohar, Rotter, Varda

“…Partial gain of chromosome arm 17q is an abundant aberrancy in various cancer types such as lung and prostate cancer with a prominent occurrence and prognostic…”
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SPATA18, a Spermatogenesis-Associated Gene, Is a Novel Transcriptional Target of p53 and p63 by Bornstein, Chamutal, Brosh, Ran, Molchadsky, Alina, Madar, Shalom, Kogan-Sakin, Ira, Goldstein, Ido, Chakravarti, Deepavali, Flores, Elsa R., Goldfinger, Naomi, Sarig, Rachel, Rotter, Varda

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss by Brosh, Ran, Sarig, Rachel, Natan, Elad Bar, Molchadsky, Alina, Madar, Shalom, Bornstein, Chamutal, Buganim, Yosef, Shapira, Tirosh, Goldfinger, Naomi, Paus, Ralf, Rotter, Varda

“…The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription…”
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Beyond tumor suppression: p53 controls blastocyst implantation by Madar, Shalom, Goldstein, Ido, Neeman, Ortal, Rotter, Varda

“…Comment on: Sohr S, et al. Cell Cycle 2011; 10:3758-67…”
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Unleash the wild type: Restoration of p53 suppressive activity in skin cancer by Madar, Shalom, Stambolsky, Perry, Rotter, Varda

“…Comment on: Bao MC, et al. Cell Cycle 2011; 10:301-307…”
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Same stem cells but different: Isogenic embryonic stem cells harboring different p53 mutants by Madar, Shalom, Solomon, Hilla, Rotter, Varda

“…Comment on: Wei QX, et al. Cell Cycle 2011; 10:1261-70…”
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Inactivation of Myocardin and p16 during Malignant Transformation Contributes to a Differentiation Defect by Milyavsky, Michael, Shats, Igor, Cholostoy, Alina, Brosh, Ran, Buganim, Yosef, Weisz, Lilach, Kogan, Ira, Cohen, Merav, Shatz, Maria, Madar, Shalom, Kalo, Eyal, Goldfinger, Naomi, Yuan, Jun, Ron, Shulamit, MacKenzie, Karen, Eden, Amir, Rotter, Varda

“…Myocardin is known as an important transcriptional regulator in smooth and cardiac muscle development. Here we found that myocardin is frequently repressed…”
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Mutant p53 gain of function is interwoven into the hallmarks of cancer by Solomon, Hilla, Madar, Shalom, Rotter, Varda

“…Cancer is viewed as being governed by several aberrant biological events defined by Weinberg and Hanahan as ‘hallmarks’. In most human cancers the tumour…”
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p53, a novel regulator of lipid metabolism pathways by Goldstein, Ido, Ezra, Osnat, Rivlin, Noa, Molchadsky, Alina, Madar, Shalom, Goldfinger, Naomi, Rotter, Varda

“…Background & Aims In this study we aimed at characterizing the regulation of hepatic metabolic pathways by the p53 transcription factor. Methods Analysis of…”
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Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53 by Goldstein, Ido, Rivlin, Noa, Shoshana, Or-yam, Ezra, Osnat, Madar, Shalom, Goldfinger, Naomi, Rotter, Varda

“…Cytochrome P450 (P450) enzymes are abundantly expressed in the human liver where they hydroxylate organic substrates. In a microarray screen performed in human…”
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Cancer research, a field on the verge of a paradigm shift? by Goldstein, Ido, Madar, Shalom, Rotter, Varda

“…The theoretical framework for the field of cancer research is based on two main principles. The first is that cancer advances in a stepwise manner, with each…”
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Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature by Solomon, Hilla, Buganim, Yosef, Kogan-Sakin, Ira, Pomeraniec, Leslie, Assia, Yael, Madar, Shalom, Goldstein, Ido, Brosh, Ran, Kalo, Eyal, Beatus, Tsevi, Goldfinger, Naomi, Rotter, Varda

“…Concomitant expression of mutant p53 and oncogenic Ras, leading to cellular transformation, is well documented. However, the mechanisms by which the various…”
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Polyploidization of murine mesenchymal cells is associated with suppression of the long noncoding RNA H19 and reduced tumorigenicity by Shoshani, Ofer, Massalha, Hassan, Shani, Nir, Kagan, Sivan, Ravid, Orly, Madar, Shalom, Trakhtenbrot, Luba, Leshkowitz, Dena, Rechavi, Gideon, Zipori, Dov

“…Mesenchymal stromal cells (MSC) are used extensively in clinical trials; however, the possibility that MSCs have a potential for malignant transformation was…”
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