Search Results - "Madan, Upasna"
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Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions
Published in Frontiers in immunology (07-03-2023)“…Cytokine release syndrome (CRS) due to severe acute respiratory coronavirus-2 (SARS-CoV-2) infection leads to life-threatening pneumonia which has been…”
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Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis
Published in Frontiers in immunology (27-09-2022)“…Severe coronavirus disease (COVID-19) is accompanied by acute respiratory distress syndrome and pulmonary pathology, and is presented mostly with an…”
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Evaluation of Ayush-64 (a Polyherbal Formulation) and Its Ingredients in the Syrian Hamster Model for SARS-CoV-2 Infection Reveals the Preventative Potential of Alstonia scholaris
Published in Pharmaceuticals (Basel, Switzerland) (21-09-2023)“…In the current study, we evaluated the efficacy of Ayush-64 (A64), a polyherbal formulation containing (L.) R. Br. ( ), L. ( ), Royle ex Benth ( ), and (Roxb.)…”
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Proinflammatory Innate Cytokines and Distinct Metabolomic Signatures Shape the T Cell Response in Active COVID-19
Published in Vaccines (Basel) (01-10-2022)“…The underlying factors contributing to the evolution of SARS-CoV-2-specific T cell responses during COVID-19 infection remain unidentified. To address this, we…”
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Cenicriviroc, a CCR2/CCR5 antagonist, promotes the generation of type 1 regulatory T cells
Published in European journal of immunology (01-07-2024)“…Cenicriviroc, a dual CCR2/CCR5 antagonist, initially developed as an anti‐HIV drug, has shown promising results in nonalcoholic steatohepatitis phase 2…”
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Artemotil mediates protection in experimental colitis through the induction of Type 1 regulatory T cells
Published in The Journal of immunology (1950) (01-05-2023)“…Abstract Artemotil (β-arteether) is a semi-synthetic derivative of artemisinin - a natural compound isolated from the plant Artemisia annuaand used worldwide…”
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A noncanonical NF-kB - β-catenin signaling axis in dendritic cells instructs gut inflammation
Published in The Journal of immunology (1950) (01-05-2023)“…Abstract Dendritic cells (DCs) balance intestinal homeostasis against inflammatory insults. In particular, the noncanonical NF-kB pathway, which activates…”
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Inhibition of early RNA replication in Chikungunya and Dengue virus by lycorine: In vitro and in silico studies
Published in Biochemical and biophysical research communications (20-10-2024)“…Arboviruses such as chikungunya virus (CHIKV) and dengue virus (DENV) collectively afflict millions of individuals worldwide particularly in endemic countries…”
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Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies
Published in The EMBO journal (25-07-2024)“…Dendritic cell (DC) dysfunction is known to exacerbate intestinal pathologies, but the mechanisms compromising DC-mediated immune regulation in this context…”
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Evaluation of Ayush-64 and Its Ingredients in the Syrian Hamster Model for SARS-CoV-2 Infection Reveals the Preventative Potential of IAlstonia scholaris/I
Published in Pharmaceuticals (Basel, Switzerland) (01-09-2023)“…In the current study, we evaluated the efficacy of Ayush-64 (A64), a polyherbal formulation containing Alstonia scholaris (L.) R. Br. (A. scholaris),…”
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Understanding the landscape of the SARS‐CoV‐2‐specific T cells post‐omicron surge
Published in Journal of medical virology (01-08-2024)“…Emerging evidence shows increased humoral response post‐omicron surge, but research on T cell responses is limited. This study investigated the durability,…”
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