Search Results - "Madala, Satish"

Searching for an Animal Model with Clinical Features of Scleroderma by Vliagoftis, Harissios, Madala, Satish K

“…Vliagoftis and Madala discuss the study by Mattoo and colleagues which characterize the progressive molecular changes in the pathogenesis of scleroderma and…”
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ASK1ng to Delay the Progression of Pulmonary Fibrosis by Schuliga, Michael, Madala, Satish K

“…Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein kinase (MAPK) family that regulates c-Jun N-terminal kinase (JNK) and…”
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Extracellular small heat shock proteins: exosomal biogenesis and function by Reddy, V. Sudhakar, Madala, Satish K., Trinath, Jamma, Reddy, G. Bhanuprakash

“…Small heat shock proteins (sHsps) belong to the family of heat shock proteins (Hsps): some are induced in response to multiple stressful events to protect the…”
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Lung Fibrosis Finds an Unsung Hero in Neuropeptide Y by Madala, Satish K, Reznikov, Leah R

“…Madala and Reznikov discuss the study by Itano et al which suggests that neuropeptides are critical effectors of fibrosis progression in the lungs. The team…”
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IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function by Singh, Brijendra, Jegga, Anil G, Shanmukhappa, Kumar S, Edukulla, Ramakrishna, Khurana Hershey, Gurjit H, Medvedovic, Mario, Dillon, Stacey R, Madala, Satish K

“…Interleukin-31 (IL-31) is a type 2 helper T-cell-derived cytokine that has recently been shown to cause severe inflammation and tissue remodeling in multiple…”
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Mechanisms of Lung Fibrosis Resolution by Glasser, Stephan W, Hagood, James S, Wong, Simon, Taype, Carmen A, Madala, Satish K, Hardie, William D

“…Fibrogenesis involves a dynamic interplay between factors that promote the biosynthesis and deposition of extracellular matrix along with pathways that degrade…”
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Notch3: A New Culprit in Fibrotic Lung Disease by Gajjala, Prathibha R, Madala, Satish K

“…Gajjala and Madala discuss the study by Vera et al concerning the pathogenic role for Notch3 in fibroblast activation and pulmonary fibrosis. They showed that…”
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Cardiac metabolic pathways affected in the mouse model of barth syndrome by Huang, Yan, Powers, Corey, Madala, Satish K, Greis, Kenneth D, Haffey, Wendy D, Towbin, Jeffrey A, Purevjav, Enkhsaikhan, Javadov, Sabzali, Strauss, Arnold W, Khuchua, Zaza

“…Cardiolipin (CL) is a mitochondrial phospholipid essential for electron transport chain (ETC) integrity. CL-deficiency in humans is caused by mutations in the…”
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Consensus Gene Co-Expression Network Analysis Identifies Novel Genes Associated with Severity of Fibrotic Lung Disease by Ghandikota, Sudhir, Sharma, Mihika, Ediga, Harshavardhana H, Madala, Satish K, Jegga, Anil G

“…Idiopathic pulmonary fibrosis (IPF) is a severe fibrotic lung disease characterized by irreversible scarring of the lung parenchyma leading to dyspnea,…”
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MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation by Madala, Satish K, Schmidt, Stephanie, Davidson, Cynthia, Ikegami, Machiko, Wert, Susan, Hardie, William D

“…Pulmonary fibrosis remains a significant public health burden with no proven therapies. The mitogen-activated protein kinase (MAPK)/MAPK kinase…”
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Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma by Akkenepally, Santhoshi V., Yombo, Dan J. K., Yerubandi, Sanjana, Reddy, Geereddy Bhanuprakash, Deshpande, Deepak A., McCormack, Francis X., Madala, Satish K.

“…Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and goblet cell hyperplasia. Multiple…”
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Nε-Carboxymethyl-Lysine Modification of Extracellular Matrix Proteins Augments Fibroblast Activation by Ediga, Harshavardhana H, Hester, Patrick, Yepuri, Adithi, Reddy, Geereddy Bhanuprakash, Madala, Satish K

“…The extracellular matrix (ECM) is a dynamic complex protein network that provides structural integrity and plays an active role in shaping fibroblast behavior…”
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The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis by Yombo, Dan J K, Odayar, Varshini, Gupta, Nishant, Jegga, Anil G, Madala, Satish K

“…Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by excessive collagen deposition and progressive decline in lung function…”
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Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis by Kasam, Rajesh K, Ghandikota, Sudhir, Soundararajan, Divyalakshmi, Reddy, Geereddy B, Huang, Steven K, Jegga, Anil G, Madala, Satish K

“…Fibroblast activation including proliferation, survival, and ECM production is central to initiation and maintenance of fibrotic lesions in idiopathic…”
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Pulmonary fibroelastosis - A review by Yombo, Dan J K, Madala, Satish K, Vemulapalli, Chanukya P, Ediga, Harshavardhana H, Hardie, William D

“…Elastin is a long-lived fibrous protein that is abundant in the extracellular matrix of the lung. Elastic fibers provide the lung the characteristic elasticity…”
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Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea by Russell, Nicholas X, Burra, Kaulini, Shah, Ronak M, Bottasso-Arias, Natalia, Mohanakrishnan, Megha, Snowball, John, Ediga, Harshavardhana H, Madala, Satish K, Sinner, Debora

“…Ion channels play critical roles in the physiology and function of the nervous system and contractile tissue; however, their role in noncontractile tissue and…”
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Repetitive intradermal bleomycin injections evoke T-helper cell 2 cytokine-driven pulmonary fibrosis by Singh, Brijendra, Kasam, Rajesh K, Sontake, Vishwaraj, Wynn, Thomas A, Madala, Satish K

“…IL-4 and IL-13 are major T-helper cell (Th) 2 cytokines implicated in the pathogenesis of several lung diseases, including pulmonary fibrosis. In this study,…”
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Heat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation by Yombo, Dan J.K., Mentink-Kane, Margaret M., Wilson, Mark S., Wynn, Thomas A., Madala, Satish K.

“…Heat shock proteins (Hsps) are highly conserved molecular chaperones that are ubiquitously expressed in all species to aid the solubilization of misfolded…”
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Reply: tissue fibrocytes are a subpopulation of macrophages by Madala, Satish K

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New therapeutics based on emerging concepts in pulmonary fibrosis by Sontake, Vishwaraj, Gajjala, Prathibha R, Kasam, Rajesh K, Madala, Satish K

“…Fibrosis is an irreversible pathological endpoint in many chronic diseases, including pulmonary fibrosis. Idiopathic pulmonary fibrosis (IPF) is a progressive…”
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