Search Results - "Madaj, Zachary"

An osteocalcin-deficient mouse strain without endocrine abnormalities by Diegel, Cassandra R, Hann, Steven, Ayturk, Ugur M, Hu, Jennifer C W, Lim, Kyung-Eun, Droscha, Casey J, Madaj, Zachary B, Foxa, Gabrielle E, Izaguirre, Isaac, Transgenics Core, Vai Vivarium And, Paracha, Noorulain, Pidhaynyy, Bohdan, Dowd, Terry L, Robling, Alexander G, Warman, Matthew L, Williams, Bart O

“…Osteocalcin (OCN), the most abundant noncollagenous protein in the bone matrix, is reported to be a bone-derived endocrine hormone with wide-ranging effects on…”
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Dual Inhibition of DNA and Histone Methyltransferases Increases Viral Mimicry in Ovarian Cancer Cells by Liu, Minmin, Thomas, Stacey L, DeWitt, Ashley K, Zhou, Wanding, Madaj, Zachary B, Ohtani, Hitoshi, Baylin, Stephen B, Liang, Gangning, Jones, Peter A

“…Ovarian cancer ranks as the most deadly gynecologic cancer, and there is an urgent need to develop more effective therapies. Previous studies have shown that…”
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Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans by Senchuk, Megan M, Dues, Dylan J, Schaar, Claire E, Johnson, Benjamin K, Madaj, Zachary B, Bowman, Megan J, Winn, Mary E, Van Raamsdonk, Jeremy M

“…Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species including worms, flies and mice. Here, we study three C…”
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Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin by Waldhart, Althea N., Dykstra, Holly, Peck, Anderson S., Boguslawski, Elissa A., Madaj, Zachary B., Wen, Jennifer, Veldkamp, Kelsey, Hollowell, Matthew, Zheng, Bin, Cantley, Lewis C., McGraw, Timothy E., Wu, Ning

“…Growth factors, such as insulin, can induce both acute and long-term glucose uptake into cells. Apart from the rapid, insulin-induced fusion of glucose…”
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Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Nonclinical Models by Engstrom, Lars D, Aranda, Ruth, Lee, Matthew, Tovar, Elizabeth A, Essenburg, Curt J, Madaj, Zachary, Chiang, Harrah, Briere, David, Hallin, Jill, Lopez-Casas, Pedro P, Baños, Natalia, Menendez, Camino, Hidalgo, Manuel, Tassell, Vanessa, Chao, Richard, Chudova, Darya I, Lanman, Richard B, Olson, Peter, Bazhenova, Lyudmilla, Patel, Sandip Pravin, Graveel, Carrie, Nishino, Mizuki, Shapiro, Geoffrey I, Peled, Nir, Awad, Mark M, Jänne, Pasi A, Christensen, James G

“…exon 14 deletion ( ex14 del) mutations represent a novel class of non-small cell lung cancer (NSCLC) driver mutations. We evaluated glesatinib, a…”
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The vermiform appendix impacts the risk of developing Parkinson's disease by Killinger, Bryan A, Madaj, Zachary, Sikora, Jacek W, Rey, Nolwen, Haas, Alec J, Vepa, Yamini, Lindqvist, Daniel, Chen, Honglei, Thomas, Paul M, Brundin, Patrik, Brundin, Lena, Labrie, Viviane

“…The pathogenesis of Parkinson's disease (PD) involves the accumulation of aggregated α-synuclein, which has been suggested to begin in the gastrointestinal…”
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Deficits in olfactory sensitivity in a mouse model of Parkinson’s disease revealed by plethysmography of odor-evoked sniffing by Johnson, Michaela E., Bergkvist, Liza, Mercado, Gabriela, Stetzik, Lucas, Meyerdirk, Lindsay, Wolfrum, Emily, Madaj, Zachary, Brundin, Patrik, Wesson, Daniel W.

“…Hyposmia is evident in over 90% of Parkinson’s disease (PD) patients. A characteristic of PD is intraneuronal deposits composed in part of α-synuclein fibrils…”
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Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson's disease by George, Sonia, Rey, Nolwen L, Tyson, Trevor, Esquibel, Corinne, Meyerdirk, Lindsay, Schulz, Emily, Pierce, Steven, Burmeister, Amanda R, Madaj, Zachary, Steiner, Jennifer A, Escobar Galvis, Martha L, Brundin, Lena, Brundin, Patrik

“…Cell-to-cell propagation of α-synuclein (α-syn) aggregates is thought to contribute to the pathogenesis of Parkinson's disease (PD) and underlie the spread of…”
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An inflammatory profile linked to increased suicide risk by Keaton, Sarah A., Madaj, Zachary B., Heilman, Patrick, Smart, LeAnn, Grit, Jamie, Gibbons, Robert, Postolache, Teodor T., Roaten, Kimberly, Achtyes, Eric D., Brundin, Lena

“…• We identified a distinct immunobiological profile linked to cross-diagnostic suicide risk in women with mood disorders, attending a psychiatric outpatient…”
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Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease by Ghosh, Anamitra, Tyson, Trevor, George, Sonia, Hildebrandt, Erin N, Steiner, Jennifer A, Madaj, Zachary, Schulz, Emily, Machiela, Emily, McDonald, William G, Escobar Galvis, Martha L, Kordower, Jeffrey H, Van Raamsdonk, Jeremy M, Colca, Jerry R, Brundin, Patrik

“…Mitochondrial and autophagic dysfunction as well as neuroinflammation are involved in the pathophysiology of Parkinson's disease (PD). We hypothesized that…”
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Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner by Harlow, Matt L, Chasse, Maggie H, Boguslawski, Elissa A, Sorensen, Katie M, Gedminas, Jenna M, Kitchen-Goosen, Susan M, Rothbart, Scott B, Taslim, Cenny, Lessnick, Stephen L, Peck, Anderson S, Madaj, Zachary B, Bowman, Megan J, Grohar, Patrick J

“…The successful clinical translation of compounds that target specific oncogenic transcription factors will require an understanding of the mechanism of target…”
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A diverse proteome is present and enzymatically active in metabolite extracts by House, Rachel (Rae) J., Soper-Hopper, Molly T., Vincent, Michael P., Ellis, Abigail E., Capan, Colt D., Madaj, Zachary B., Wolfrum, Emily, Isaguirre, Christine N., Castello, Carlos D., Johnson, Amy B., Escobar Galvis, Martha L., Williams, Kelsey S., Lee, Hyoungjoo, Sheldon, Ryan D.

“…Metabolite extraction is the critical first-step in metabolomics experiments, where it is generally regarded to inactivate and remove proteins. Here, arising…”
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Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue by Waldhart, Althea N., Muhire, Brejnev, Johnson, Ben, Pettinga, Dean, Madaj, Zachary B., Wolfrum, Emily, Dykstra, Holly, Wegert, Vanessa, Pospisilik, J. Andrew, Han, Xianlin, Wu, Ning

“…Hyperglycemia affects over 400 million individuals worldwide. The detrimental health effects are well studied at the tissue level, but the in vivo effects at…”
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Independent validation of experimental results requires timely and unrestricted access to animal models and reagents by Diegel, Cassandra R, Hann, Steven, Ayturk, Ugur M, Hu, Jennifer C.W, Lim, Kyung-Eun, Droscha, Casey J, Madaj, Zachary B, Foxa, Gabrielle E, Izaguirre, Isaac, Robling, Alexander G, Warman, Matthew L, Williams, Bart O

“…About the Authors: Cassandra R. Diegel Affiliation: Program in Skeletal Disease and Tumor Microenvironment and Center for Cancer and Cell Biology, Van Andel…”
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α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb by Rey, Nolwen L, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer A, Melki, Ronald, Brundin, Patrik

“…Alpha-synuclein inclusions, the hallmarks of synucleinopathies, are suggested to spread along neuronal connections in a stereotypical pattern in the brains of…”
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Dysregulated placental expression of kynurenine pathway enzymes is associated with inflammation and depression in pregnancy by Sha, Qiong, Escobar Galvis, Martha L, Madaj, Zachary B., Keaton, Sarah A., Smart, LeAnn, Edgerly, Yvonne M., Anis, Ehraz, Leach, Richard, Osborne, Lauren M., Achtyes, Eric, Brundin, Lena

“…•Women with moderate-severe depressive symptoms in late pregnancy have lower placental QPRT and ACMSD expression.•Low expression of placental IDO and QPRT…”
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Biochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles by Graham, Stewart F, Rey, Nolwen L, Yilmaz, Ali, Kumar, Praveen, Madaj, Zachary, Maddens, Michael, Bahado-Singh, Ray O, Becker, Katelyn, Schulz, Emily, Meyerdirk, Lindsay K, Steiner, Jennifer A, Ma, Jiyan, Brundin, Patrik

“…Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well…”
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Cell Context Is the Third Axis of Synergy for the Combination of ATR Inhibition and Cisplatin in Ewing Sarcoma by Jess, Jennifer, Sorensen, Katie M, Boguslawski, Elissa A, Stout, Matthew C, Madaj, Zachary B, Caiello, Benjamin P, Pomaville, Monica, Wilson, Elizabeth R, Kinn-Gurzo, Seneca S, Parker, Curtis C, Veluvolu, Sridhar M, Brysgel, Taylor V, Kaufman, Rebecca, Kitchen-Goosen, Susan M, Gedminas, Jenna M, Grohar, Patrick J

“…The importance of cellular context to the synergy of DNA damage response (DDR)-targeted agents is important for tumors with mutations in DDR pathways, but less…”
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Enzalutamide-induced and PTH1R-mediated TGFBR2 degradation in osteoblasts confers resistance in prostate cancer bone metastases by Su, Shang, Cao, Jingchen, Meng, Xiangqi, Liu, Ruihua, Vander Ark, Alexandra, Woodford, Erica, Zhang, Reian, Stiver, Isabelle, Zhang, Xiaotun, Madaj, Zachary B., Bowman, Megan J., Wu, Yingying, Xu, H. Eric, Chen, Bin, Yu, Haiquan, Li, Xiaohong

“…Enzalutamide resistance has been observed in approximately 50% of patients with prostate cancer (PCa) bone metastases. Therefore, there is an urgent need to…”
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Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus by Harlow, Matt L, Maloney, Nichole, Roland, Joseph, Guillen Navarro, Maria Jose, Easton, Matthew K, Kitchen-Goosen, Susan M, Boguslawski, Elissa A, Madaj, Zachary B, Johnson, Ben K, Bowman, Megan J, D'Incalci, Maurizio, Winn, Mary E, Turner, Lisa, Hostetter, Galen, Galmarini, Carlos María, Aviles, Pablo M, Grohar, Patrick J

“…There is a great need to develop novel approaches to target oncogenic transcription factors with small molecules. Ewing sarcoma is emblematic of this need, as…”
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