Search Results - "Macrae, Fraser L."

Thrombus Structural Composition in Cardiovascular Disease by Alkarithi, Ghadir, Duval, Cédric, Shi, Yu, Macrae, Fraser L., Ariëns, Robert A.S.

“…Thrombosis is a major complication of cardiovascular disease, leading to myocardial infarction, acute ischemic stroke, or venous thromboembolism. Thrombosis…”
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A fibrin biofilm covers blood clots and protects from microbial invasion by Macrae, Fraser L, Duval, Cédric, Papareddy, Praveen, Baker, Stephen R, Yuldasheva, Nadira, Kearney, Katherine J, McPherson, Helen R, Asquith, Nathan, Konings, Joke, Casini, Alessandro, Degen, Jay L, Connell, Simon D, Philippou, Helen, Wolberg, Alisa S, Herwald, Heiko, Ariëns, Robert As

“…Hemostasis requires conversion of fibrinogen to fibrin fibers that generate a characteristic network, interact with blood cells, and initiate tissue repair…”
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The prothrombotic state in paroxysmal nocturnal hemoglobinuria: a multifaceted source by Peacock-Young, Barnaby, Macrae, Fraser L, Newton, Darren J, Hill, Anita, Ariëns, Robert A S

“…Paroxysmal nocturnal hemoglobinuria is a rare acquired hematologic disorder, the most serious complication of which is thrombosis. The increased incidence of…”
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Plasma from patients with pulmonary embolism show aggregates that reduce after anticoagulation by Baker, Stephen R., Halliday, Georgia, Ząbczyk, Michal, Alkarithi, Ghadir, Macrae, Fraser L., Undas, Anetta, Hunt, Beverley J., Ariëns, Robert A. S.

“…Background Microclots, a term also used for amyloid fibrin(ogen) particles and henceforth named aggregates, have recently been reported in the plasma of…”
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Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications by Kearney, Katherine J., Pechlivani, Nikoletta, King, Rhodri, Tiede, Christian, Phoenix, Fladia, Cheah, Ramsah, Macrae, Fraser L., Simmons, Katie J., Manfield, Iain W., Smith, Kerrie A., Spurgeon, Benjamin E.J., Naseem, Khalid M., Ariens, Robert A.S., McPherson, Michael J., Tomlinson, Darren C., Ajjan, Ramzi A.

“…Bleeding complications secondary to surgery, trauma, or coagulation disorders are important causes of morbidity and mortality. Although fibrin sealants are…”
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Common FXIII and fibrinogen polymorphisms in abdominal aortic aneurysms by Macrae, Fraser L, Evans, Hannah Lee, Bridge, Katherine I, Johnson, Anne, Scott, D Julian A, Ariëns, Robert A S

“…Abdominal aortic aneurysms (AAA) are characterized by a progressive dilatation of the abdominal aorta, and are associated with a high risk of rupture once the…”
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The Role of Fibrin(ogen) in Wound Healing and Infection Control by Kearney, Katherine J, Ariëns, Robert A S, Macrae, Fraser L

“…Fibrinogen, one of the most abundant plasma proteins playing a key role in hemostasis, is an important modulator of wound healing and host defense against…”
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Fibrin-glycoprotein VI interaction increases platelet procoagulant activity and impacts clot structure by Gauer, Julia S., Duval, Cédric, Xu, Rui-Gang, Macrae, Fraser L., McPherson, Helen R., Tiede, Christian, Tomlinson, Darren, Watson, Steve P., Ariëns, Robert A.S.

“…The glycoprotein VI (GPVI) signaling pathway was previously reported to direct procoagulant platelet activity through collagen binding. However, the impact of…”
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Recurrent venous thromboembolism patients form clots with lower elastic modulus than those formed by patients with non‐recurrent disease by Baker, Stephen R., Zabczyk, Michal, Macrae, Fraser L., Duval, Cédric, Undas, Anetta, Ariëns, Robert A. S.

“…Essentials Venous thromboembolism (VTE) recurrence leads to decreased clot elastic modulus in plasma. Recurrent VTE is not linked to changes in clot structure,…”
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Thrombin and fibrinogen γ′ impact clot structure by marked effects on intrafibrillar structure and protofibril packing by Domingues, Marco M., Macrae, Fraser L., Duval, Cédric, McPherson, Helen R., Bridge, Katherine I., Ajjan, Ramzi A., Ridger, Victoria C., Connell, Simon D., Philippou, Helen, Ariëns, Robert A.S.

“…Previous studies have shown effects of thrombin and fibrinogen γ′ on clot structure. However, structural information was obtained using electron microscopy,…”
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Thrombin cleavage of the hepatitis E virus polyprotein at multiple conserved locations is required for genome replication by Pierce, Danielle M, Buchanan, Frazer J T, Macrae, Fraser L, Mills, Jake T, Cox, Abigail, Abualsaoud, Khadijah M, Ward, Joseph C, Ariëns, Robert A S, Harris, Mark, Stonehouse, Nicola J, Herod, Morgan R

“…The genomes of positive-sense RNA viruses encode polyproteins that are essential for mediating viral replication. These viral polyproteins must undergo…”
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The (Patho)physiology of Fibrinogen γ by Macrae, Fraser L, Domingues, Marco M, Casini, Alessandro, Ariëns, Robert A S

“…Fibrinogen γ' is a splice variant of the fibrinogen γ-chain, which leads to a negatively charged extension at the C-terminus of the γ-chain. In fibrinogen, the…”
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High fibrinogen γ′ levels in patient plasma increase clot formation at arterial and venous shear by Macrae, Fraser L., Swieringa, Frauke, Heemskerk, Johan W.M., Ariëns, Robert A.S.

“…Fibrinogen γ’ accounts for 3% to 40% of plasma fibrinogen. Earlier studies indicated that fibrinogen γ’ forms altered fibrin clots under static conditions,…”
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Patients with paroxysmal nocturnal hemoglobinuria demonstrate a prothrombotic clotting phenotype which is improved by complement inhibition with eculizumab by Macrae, Fraser L., Peacock‐Young, Barnaby, Bowman, Polly, Baker, Stephen R., Quested, Sam, Linton, Emma, Hillmen, Peter, Griffin, Morag, Munir, Talha, Payne, Daniel, McKinley, Claire, Clarke, Deborah, Newton, Darren J, Hill, Anita, Ariëns, Robert A. S.

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder, characterized by complement‐mediated intravascular hemolysis and thrombosis. The…”
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Sensing adhesion forces between erythrocytes and γ’ fibrinogen, modulating fibrin clot architecture and function by Guedes, Ana Filipa, Carvalho, Filomena A., Domingues, Marco M., Macrae, Fraser L., McPherson, Helen R., Santos, Nuno C., Ariёns, Robert A.S.

“…Plasma fibrinogen includes an alternatively spliced γ-chain variant (γ’), which mainly exists as a heterodimer (γAγ’) and has been associated with thrombosis…”
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Impact of γ′γ′ fibrinogen interaction with red blood cells on fibrin clots by Guedes, Ana Filipa, Carvalho, Filomena A, Domingues, Marco M, Macrae, Fraser L, McPherson, Helen R, Sabban, Aliaa, Martins, Ivo C, Duval, Cédric, Santos, Nuno C, Ariëns, Robert AS

“…γ′ fibrinogen has been associated with thrombosis. Here the interactions between γ′γ′ or γAγA fibrinogen and red blood cells (RBCs), and their role on fibrin…”
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The 95RGD97 sequence on the Aα chain of fibrinogen is essential for binding to its erythrocyte receptor by Carvalho, Filomena A, Guedes, Ana Filipa, Duval, Cedric, Macrae, Fraser L, Swithenbank, Luke, Farrell, David H, Ariëns, Robert AS, Santos, Nuno C

“…Background: Erythrocyte aggregation, a cardiovascular risk factor, is increased by high plasma fibrinogen levels. Here, the effect of different fibrinogen…”
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Impact of γ'γ' fibrinogen interaction with red blood cells on fibrin clots by Guedes, Ana Filipa, Carvalho, Filomena A, Domingues, Marco M, Macrae, Fraser L, McPherson, Helen R, Sabban, Aliaa, Martins, Ivo C, Duval, Cédric, Santos, Nuno C, Ariëns, Robert As

“…γ' fibrinogen has been associated with thrombosis. Here the interactions between γ'γ' or γAγA fibrinogen and red blood cells (RBCs), and their role on fibrin…”
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Thrombus Structural Composition in Cardiovascular Disease by Alkarithi, Ghadir, Duval, Cédric, Shi, Yu, Macrae, Fraser L., Ariëns, Robert A.S.

“…Thrombosis is a major complication of cardiovascular disease, leading to myocardial infarction, acute ischemic stroke (AIS), or venous thromboembolism…”
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The [.sup.95][RGD.sub.97] sequence on the A[alpha] chain of fibrinogen is essential for binding to its erythrocyte receptor by Carvalho, Filomena A, Guedes, Ana Filipa, Duval, Cedric, Macrae, Fraser L, Swithenbank, Luke, Farrell, David H, Ariens, Robert A.S, Santos, Nuno C

“…Background: Erythrocyte aggregation, a cardiovascular risk factor, is increased by high plasma fibrinogen levels. Here, the effect of different fibrinogen…”
Get full text