Search Results - "Macrae, Calum A"

Artificial intelligence-enabled fully automated detection of cardiac amyloidosis using electrocardiograms and echocardiograms by Goto, Shinichi, Mahara, Keitaro, Beussink-Nelson, Lauren, Ikura, Hidehiko, Katsumata, Yoshinori, Endo, Jin, Gaggin, Hanna K., Shah, Sanjiv J., Itabashi, Yuji, MacRae, Calum A., Deo, Rahul C.

“…Patients with rare conditions such as cardiac amyloidosis (CA) are difficult to identify, given the similarity of disease manifestations to more prevalent…”
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Lysolipids in Vascular Development, Biology, and Disease by Engelbrecht, Eric, MacRae, Calum A., Hla, Timothy

“…Membrane phospholipid metabolism forms lysophospholipids, which possess unique biochemical and biophysical properties that influence membrane structure and…”
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Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration by Mahmoud, Ahmed I., O’Meara, Caitlin C., Gemberling, Matthew, Zhao, Long, Bryant, Donald M., Zheng, Ruimao, Gannon, Joseph B., Cai, Lei, Choi, Wen-Yee, Egnaczyk, Gregory F., Burns, Caroline E., Burns, C. Geoffrey, MacRae, Calum A., Poss, Kenneth D., Lee, Richard T.

“…Some organisms, such as adult zebrafish and newborn mice, have the capacity to regenerate heart tissue following injury. Unraveling the mechanisms of heart…”
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Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection by Goto, Shinichi, Solanki, Divyarajsinhji, John, Jenine E., Yagi, Ryuichiro, Homilius, Max, Ichihara, Genki, Katsumata, Yoshinori, Gaggin, Hanna K., Itabashi, Yuji, MacRae, Calum A., Deo, Rahul C.

“…Novel targeted treatments increase the need for prompt hypertrophic cardiomyopathy (HCM) detection. However, its low prevalence (0.5%) and resemblance to…”
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Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration by Zhao, Long, Borikova, Asya L., Ben-Yair, Raz, Guner-Ataman, Burcu, MacRae, Calum A., Lee, Richard T., Burns, C. Geoffrey, Burns, Caroline E.

“…The human heart’s failure to replace ischemia-damaged myocardium with regenerated muscle contributes significantly to the worldwide morbidity and mortality…”
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Systematic Approaches to Toxicology in the Zebrafish by PETERSON, Randall T, MACRAE, Calum A

“…As the current paradigms of drug discovery evolve, it has become clear that a more comprehensive understanding of the interactions between small molecules and…”
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Artificial intelligence-enabled prediction of chemotherapy-induced cardiotoxicity from baseline electrocardiograms by Yagi, Ryuichiro, Goto, Shinichi, Himeno, Yukihiro, Katsumata, Yoshinori, Hashimoto, Masahiro, MacRae, Calum A., Deo, Rahul C.

“…Anthracyclines can cause cancer therapy-related cardiac dysfunction (CTRCD) that adversely affects prognosis. Despite guideline recommendations, only half of…”
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Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes by Kikuchi, Kazu, Holdway, Jennifer E., Werdich, Andreas A., Anderson, Ryan M., Fang, Yi, Egnaczyk, Gregory F., Evans, Todd, MacRae, Calum A., Stainier, Didier Y. R., Poss, Kenneth D.

“…Cardiac regeneration Zebrafish are able to efficiently regenerate lost cardiac muscle, and is used as a model to understand why natural heart regeneration is…”
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Fine Mapping of the 1p36 Deletion Syndrome Identifies Mutation of PRDM16 as a Cause of Cardiomyopathy by Arndt, Anne-Karin, Schafer, Sebastian, Drenckhahn, Jorg-Detlef, Sabeh, M. Khaled, Plovie, Eva R., Caliebe, Almuth, Klopocki, Eva, Musso, Gabriel, Werdich, Andreas A., Kalwa, Hermann, Heinig, Matthias, Padera, Robert F., Wassilew, Katharina, Bluhm, Julia, Harnack, Christine, Martitz, Janine, Barton, Paul J., Greutmann, Matthias, Berger, Felix, Hubner, Norbert, Siebert, Reiner, Kramer, Hans-Heiner, Cook, Stuart A., MacRae, Calum A., Klaassen, Sabine

“…Deletion 1p36 syndrome is recognized as the most common terminal deletion syndrome. Here, we describe the loss of a gene within the deletion that is…”
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MIC-Drop: A platform for large-scale in vivo CRISPR screens by Parvez, Saba, Herdman, Chelsea, Beerens, Manu, Chakraborti, Korak, Harmer, Zachary P, Yeh, Jing-Ruey J, MacRae, Calum A, Yost, H Joseph, Peterson, Randall T

“…CRISPR-Cas9 can be scaled up for large-scale screens in cultured cells, but CRISPR screens in animals have been challenging because generating, validating, and…”
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Rapid behavior-based identification of neuroactive small molecules in the zebrafish by Kokel, David, Peterson, Randall T, Bryan, Jennifer, Laggner, Christian, White, Rick, Cheung, Chung Yan J, Mateus, Rita, Healey, David, Kim, Sonia, Werdich, Andreas A, Haggarty, Stephen J, MacRae, Calum A, Shoichet, Brian

“…Despite the need for new psychoactive drugs, there are few robust approaches for discovering novel neuroactive molecules. Development of a behavior-based…”
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Phenotypic Manifestations of Arrhythmogenic Cardiomyopathy in Children and Adolescents by DeWitt, Elizabeth S., Chandler, Stephanie F., Hylind, Robyn J., Beausejour Ladouceur, Virginie, Blume, Elizabeth D., VanderPluym, Christina, Powell, Andrew J., Fynn-Thompson, Francis, Roberts, Amy E., Sanders, Stephen P., Bezzerides, Vassilios, Lakdawala, Neal K., MacRae, Calum A., Abrams, Dominic J.

“…Arrhythmogenic cardiomyopathy (ACM) is a variably penetrant disease increasingly identified in young patients. This study sought to describe the diverse…”
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The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion by Wang, Jinhu, Panáková, Daniela, Kikuchi, Kazu, Holdway, Jennifer E, Gemberling, Matthew, Burris, James S, Singh, Sumeet Pal, Dickson, Amy L, Lin, Yi-Fan, Sabeh, M Khaled, Werdich, Andreas A, Yelon, Deborah, Macrae, Calum A, Poss, Kenneth D

“…Natural models of heart regeneration in lower vertebrates such as zebrafish are based on invasive surgeries causing mechanical injuries that are limited in…”
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Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca2+ channel by Panáková, Daniela, Werdich, Andreas A., MacRae, Calum A.

“…Signalling cardiac currents Many important biological processes, including the normal functioning of the heart, require an electrical gradient. The mechanisms…”
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Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish by Mishra, Shikha, Guan, Jian, Plovie, Eva, Seldin, David C, Connors, Lawreen H, Merlini, Giampaolo, Falk, Rodney H, MacRae, Calum A, Liao, Ronglih

“…Systemic amyloid light-chain (AL) amyloidosis is associated with rapidly progressive and fatal cardiomyopathy resulting from the direct cardiotoxic effects of…”
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Genetics of Atrial Fibrillation by Feghaly, Julien, Zakka, Patrick, London, Barry, MacRae, Calum A, Refaat, Marwan M

“…Background Atrial fibrillation ( AF ) is a common arrhythmia seen in clinical practice. Occasionally, no common risk factors are present in patients with this…”
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Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration by Natarajan, Niranjana, Abbas, Yamen, Bryant, Donald M, Gonzalez-Rosa, Juan Manuel, Sharpe, Michka, Uygur, Aysu, Cocco-Delgado, Lucas H, Ho, Nhi Ngoc, Gerard, Norma P, Gerard, Craig J, MacRae, Calum A, Burns, Caroline E, Burns, C Geoffrey, Whited, Jessica L, Lee, Richard T

“…BACKGROUND:Defining conserved molecular pathways in animal models of successful cardiac regeneration could yield insight into why adult mammals have inadequate…”
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Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes of zebrafish by Martin, Kendall E, Ravisankar, Padmapriyadarshini, Beerens, Manu, MacRae, Calum A, Waxman, Joshua S

“…Maintenance of cardiomyocyte identity is vital for normal heart development and function. However, our understanding of cardiomyocyte plasticity remains…”
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The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3 by Cullere, Xavier, Plovie, Eva, Bennett, Paul M., MacRae, Calum A., Mayadas, Tanya N.

“…Three genes,CCM1, CCM2, andCCM3, interact genetically and biochemically and are mutated in cerebral cavernous malformations (CCM). A recently described member…”
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Chamber identity programs drive early functional partitioning of the heart by Mosimann, Christian, Panáková, Daniela, Werdich, Andreas A., Musso, Gabriel, Burger, Alexa, Lawson, Katy L., Carr, Logan A., Nevis, Kathleen R., Sabeh, M. Khaled, Zhou, Yi, Davidson, Alan J., DiBiase, Anthony, Burns, Caroline E., Burns, C. Geoffrey, MacRae, Calum A., Zon, Leonard I.

“…The vertebrate heart muscle (myocardium) develops from the first heart field (FHF) and expands by adding second heart field (SHF) cells. While both lineages…”
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