Search Results - "Macrae, A. D."

Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice by Gainetdinov, Raul R, Bohn, Laura M, Walker, Julia K.L, Laporte, Stéphane A, Macrae, Alexander D, Caron, Marc G, Lefkowitz, Robert J, Premont, Richard T

“…G protein–coupled receptor kinase 5 (GRK5) is a member of a family of enzymes that phosphorylate activated G protein–coupled receptors (GPCR). To address the…”
Get full text

Molecular cloning of two cannabinoid type 1-like receptor genes from the puffer fish Fugu rubripes by YAMAGUCHI, F, MACRAE, A. D, BRENNER, S

“…The puffer fish, Fugu rubripes (Fugu), has been proposed as a model vertebrate genome. We have characterized two putative G-protein-coupled receptor encoding…”
Get full text

Suggestions for Thought by Florence Nightingale: Selections and Commentaries by Calabria, Michael D, Macrae, Janet A

“…Florence Nightingale is best known as the founder of modern nursing, a reformer in the field of public health, and a pioneer in the use of statistics. It is…”
Get full text

Very high concentrations of islet amyloid polypeptide are necessary to alter the insulin response to intravenous glucose in man by Bretherton-Watt, D, Gilbey, S G, Ghatei, M A, Beacham, J, Macrae, A D, Bloom, S R

“…Islet amyloid polypeptide (IAPP) is a beta-cell peptide that can oppose insulin action in animal systems, but has not been shown to have any action in man;…”
Get more information

Diaphragmatic weakness in hereditary motor and sensory neuropathy by Hardie, R, Harding, A E, Hirsch, N, Gelder, C, Macrae, A D, Thomas, P K

“…Six patients severely affected by hereditary motor and sensory neuropathy (HMSN), four type I and two type II, had clinical evidence of diaphragmatic weakness…”
Get full text

One armed PCR (OA-PCR): amplification of genomic DNA from a single primer domain by Macrae, A D, Brenner, S

“…One-armed PCR (OA-PCR) is a novel technique that allows amplification of genomic DNA from a single region of known sequence. Previously described methods are…”
Get more information

Aetiology and outcome of severe community-acquired pneumonia by Woodhead, M A, Macfarlane, J T, Rodgers, F G, Laverick, A, Pilkington, R, Macrae, A D

“…Between January 1972 and December 1981, 50 patients with severe community-acquired pneumonia were admitted to the intensive care unit of a district general…”
Get more information

Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants by Premont, R T, Macrae, A D, Stoffel, R H, Chung, N, Pitcher, J A, Ambrose, C, Inglese, J, MacDonald, M E, Lefkowitz, R J

“…A novel human G protein-coupled receptor kinase was recently identified by positional cloning in the search for the Huntington's disease locus (Ambrose, C.,…”
Get full text

The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation by Premont, R T, Macrae, A D, Aparicio, S A, Kendall, H E, Welch, J E, Lefkowitz, R J

“…G protein-coupled receptor kinases (GRKs) desensitize G protein-coupled receptors by phosphorylating activated receptors. The six known GRKs have been…”
Get full text

Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain by Macrae, Alexander D., Premont, Richard T., Jaber, Mohamed, Peterson, Andrew S., Lefkowitz, Robert J.

“…During a project to identify G-protein-coupled receptors (GPCR) expressed within taste buds, we have isolated a novel receptor-like sequence. The full length…”
Get full text

Effect of diltiazem and its metabolites on the uptake of adenosine in blood: an in-vitro investigation by Yeung, P K, Mosher, S J, Macrae, D A, Klassen, G A

“…Using whole blood from man and rabbits, the effect of diltiazem, its metabolites, and other calcium antagonists on the uptake of adenosine has been described…”
Get more information

Assessment of Postural Hypotension in Elderly Patients by MACRAE, A. D., BULPITT, C. J.

“…Change in blood pressure on standing was measured in 23 geriatric inpatients during the morning. The fall in systolic blood pressure was found to be greatest…”
Get full text

Differential blocking actions of idazoxan against the inhibitory effects of 6‐fluoronoradrenaline and clonidine in the rat vas deferens by Hicks, P.E., Langer, S.Z., Macrae, A.D.

“…1 The prejunctional inhibitory effects of clonidine and 6‐fluoronoradrenaline (6‐FNA) have been evaluated in the isolated prostatic segment of the rat vas…”
Get full text

Using Zebrafish for High-Throughput Screening of Novel Cardiovascular Drugs by Kithcart, Aaron, MD, PhD, MacRae, Calum A., MD, PhD

“…Summary Cardiovascular diseases remain a major challenge for modern drug discovery. The diseases are chronic, complex, and the result of sophisticated…”
Get full text

Electron microscopy of the organism of Legionnaires' disease by RODGERS, F. G, MACRAE, A. D, LEWIS, M. J

Get full text

Analysis of the dopamine receptor family in the compact genome of the puffer fish Fugu rubripes by Macrae, Alexander D., Brenner, Sydney

“…The genome of the puffer fish, Fugu rubripes ( Fugu), is approximately 400 Mb, 7.5 times smaller than that of human. We have isolated four dopamine…”
Get full text

Palmitoylation Increases the Kinase Activity of the G Protein-Coupled Receptor Kinase, GRK6 by Stoffel, Robert H, Inglese, James, Macrae, Alexander D, Lefkowitz, Robert J, Premont, Richard T

“…The G protein-coupled receptor kinase GRK6 undergoes posttranslational modification by palmitoylation. Palmitoylated GRK6 is associated with the membrane,…”
Get full text

Legionnaires' disease in Nottingham, England by Macrae, A D, Appleton, P N, Laverick, A

“…Legionnaires' disease bacterium was identified as the cause of severe pneumonia in some Nottingham, England, patients in 1977. Laboratory studies were not…”
Get more information

Electron microscopic evidence of flagella and pili on Legionella pneumophila by Rodgers, F G, Greaves, P W, Macrae, A D, Lewis, M J

“…Twenty-one strains of Legionella pneumophila, representing the six known serotypes of the organism, cultured on various bacteriological media and in the yolk…”
Get full text

Hospital study of adult community-acquired pneumonia by Macfarlane, J T, Finch, R G, Ward, M J, Macrae, A D

“…The cause of primary pneumonia was diagnosed in 124 of 127 consecutive adult patients admitted to hospital with community-acquired illness. Pneumococcal…”
Get more information