Search Results - "Macpherson, Lindsey J"

The Coding of Temperature in the Drosophila Brain by Gallio, Marco, Ofstad, Tyler A., Macpherson, Lindsey J., Wang, Jing W., Zuker, Charles S.

“…Thermosensation is an indispensable sensory modality. Here, we study temperature coding in Drosophila, and show that temperature is represented by a spatial…”
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Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines by Macpherson, L.J, Dubin, A.E, Evans, M.J, Marr, F, Schultz, P.G, Cravatt, B.F, Patapoutian, A

“…The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the Transient Receptor Potential…”
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A hard-wired glutamatergic circuit pools and relays UV signals to mediate spectral preference in Drosophila by Karuppudurai, Thangavel, Lin, Tzu-Yang, Ting, Chun-Yuan, Pursley, Randall, Melnattur, Krishna V, Diao, Fengqiu, White, Benjamin H, Macpherson, Lindsey J, Gallio, Marco, Pohida, Thomas, Lee, Chi-Hon

“…Many visual animals have innate preferences for particular wavelengths of light, which can be modified by learning. Drosophila's preference for UV over visible…”
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From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs by Bandell, Michael, Macpherson, Lindsey J, Patapoutian, Ardem

“…Six highly temperature-sensitive ion channels of the transient receptor potential (TRP) family have been implicated to mediate temperature sensation. These…”
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An Ion Channel Essential for Sensing Chemical Damage by Macpherson, Lindsey J, Xiao, Bailong, Kwan, Kelvin Y, Petrus, Matt J, Dubin, Adrienne E, Hwang, SunWook, Cravatt, Benjamin, Corey, David P, Patapoutian, Ardem

“…Tissue damage and its downstream consequences are experimentally assayed by formaldehyde application, which indiscriminately modifies proteins and is presumed…”
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The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin by Macpherson, Lindsey J., Geierstanger, Bernhard H., Viswanath, Veena, Bandell, Michael, Eid, Samer R., Hwang, SunWook, Patapoutian, Ardem

“…Garlic’s pungent flavor has made it a popular ingredient in cuisines around the world and throughout history. Garlic’s health benefits have been elevated from…”
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More than cool: Promiscuous relationships of menthol and other sensory compounds by Macpherson, Lindsey J., Hwang, Sun Wook, Miyamoto, Takashi, Dubin, Adrienne E., Patapoutian, Ardem, Story, Gina M.

“…Several temperature-activated transient receptor potential (thermoTRP) ion channels are the molecular receptors of natural compounds that evoke thermal and…”
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Regional specialization of the tongue revealed by gustatory ganglion imaging by Fowler, Bryan E., Ye, Jiahao, Humayun, Saima, Lee, Hojoon, Macpherson, Lindsey J.

“…Gustatory information is relayed from the anterior tongue by geniculate ganglion neurons and from the posterior tongue by neurons of the petrosal portion of…”
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Temperature representation in the Drosophila brain by Frank, Dominic D., Jouandet, Genevieve C., Kearney, Patrick J., Macpherson, Lindsey J., Gallio, Marco

“…This study identifies distinct classes of neurons in the fly brain, which respond to external cooling, warming, or both, and contribute to behavioural…”
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Dynamic labelling of neural connections in multiple colours by trans-synaptic fluorescence complementation by Macpherson, Lindsey J., Zaharieva, Emanuela E., Kearney, Patrick J., Alpert, Michael H., Lin, Tzu-Yang, Turan, Zeynep, Lee, Chi-Hon, Gallio, Marco

“…Determining the pattern of activity of individual connections within a neural circuit could provide insights into the computational processes that underlie…”
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Give-and-take of gustation: the interplay between gustatory neurons and taste buds by Landon, Shannon M, Baker, Kimberly, Macpherson, Lindsey J

“…Abstract Mammalian taste buds are highly regenerative and can restore themselves after normal wear and tear of the lingual epithelium or following physical and…”
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Rewiring the taste system by Lee, Hojoon, Macpherson, Lindsey J., Parada, Camilo A., Zuker, Charles S., Ryba, Nicholas J. P.

“…Taste-receptor cells use distinct semaphorins to guide wiring of the peripheral taste system; targeted ectopic expression of SEMA3A or SEMA7A leads to bitter…”
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Cyclophosphamide induces the loss of taste bud innervation in mice by Wood, Ryan M, Vasquez, Erin L, Goyins, Krystal A, Gutierrez Kuri, Eduardo, Connelly, Kevin, Humayun, Saima, Macpherson, Lindsey J

“…Abstract Many common chemotherapeutics produce disruptions in the sense of taste which can lead to loss of appetite, nutritional imbalance, and reduced quality…”
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In vivo Calcium Imaging of Mouse Geniculate Ganglion Neuron Responses to Taste Stimuli by Fowler, Bryan E, Macpherson, Lindsey J

“…Within the last ten years, advances in genetically encoded calcium indicators (GECIs) have promoted a revolution in in vivo functional imaging. Using calcium…”
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Mechanisms for the Sour Taste by Zhang, Jin, Lee, Hojoon, Macpherson, Lindsey J

“…Sour, the taste of acids, provides important sensory information to prevent the ingestion of unripe, spoiled, or fermented foods. In mammals, acids elicit…”
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Selective Peripheral Taste Dysfunction in APP/PS1 Mutant Transgenic Mice by Wood, Ryan M, Garcia, Zacnite, Daniels, Nathan, Landon, Shannon M, Humayun, Saima, Lee, Hyoung-Gon, Macpherson, Lindsey J

“…Previous studies indicate that taste dysfunction occurs early in the development of Alzheimer's disease. It is debatable whether the deficit in taste is due…”
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Channels Flies feel your pain by Patapoutian, Ardem, Macpherson, Lindsey J

“…Evolutionary conservation of TRPA1 underlies sensation of reactive noxious chemicals from flies to humans. [PUBLICATION ABSTRACT]…”
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Flies feel your pain by Macpherson, Lindsey J, Patapoutian, Ardem

“…Evolutionary conservation of TRPA1 underlies sensation of reactive noxious chemicals from flies to humans…”
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Feeling the burn: Towards a determination of the molecular mechanisms of activation of TRPA1 by Macpherson, Lindsey J

“…Members of the TRP family of non-selective cation channels are activated in response to different temperature ranges and are implicated in temperature and pain…”
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Feeling the burn: Towards a determination of the molecular mechanisms of activation of TRPA1 by Macpherson, Lindsey J

“…Members of the TRP family of non-selective cation channels are activated in response to different temperature ranges and are implicated in temperature and pain…”
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