Search Results - "Macpherson, Iain"

Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study by Banerji, Udai, Prof, van Herpen, Carla M L, Prof, Saura, Cristina, MD, Thistlethwaite, Fiona, MD, Lord, Simon, MD, Moreno, Victor, MD, Macpherson, Iain R, MD, Boni, Valentina, MD, Rolfo, Christian, Prof, de Vries, Elisabeth G E, Prof, Rottey, Sylvie, Prof, Geenen, Jill, MD, Eskens, Ferry, MD, Gil-Martin, Marta, MD, Mommers, Ellen C, PhD, Koper, Norbert P, PhD, Aftimos, Philippe, MD

“…SummaryBackgroundTrastuzumab duocarmazine is a novel HER2-targeting antibody–drug conjugate comprised of trastuzumab covalently bound to a linker drug…”
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PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness by Rabas, Nicolas, Palmer, Sarah, Mitchell, Louise, Ismail, Shehab, Gohlke, Andrea, Riley, Joel S, Tait, Stephen W G, Gammage, Payam, Soares, Leandro Lemgruber, Macpherson, Iain R, Norman, Jim C

“…The cystine-glutamate antiporter, xCT, supports a glutathione synthesis program enabling cancer cells to cope with metabolically stressful microenvironments…”
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Recent strategies targeting HIV glycans in vaccine design by Horiya, Satoru, MacPherson, Iain S, Krauss, Isaac J

“…Carbohydrate antigens on HIV are important for viral biology as well as for recognition by glycan-reactive broadly neutralizing antibodies such as 2G12. A…”
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Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial by Turner, Nicholas C, Kingston, Belinda, Kilburn, Lucy S, Kernaghan, Sarah, Wardley, Andrew M, Macpherson, Iain R, Baird, Richard D, Roylance, Rebecca, Stephens, Peter, Oikonomidou, Olga, Braybrooke, Jeremy P, Tuthill, Mark, Abraham, Jacinta, Winter, Matthew C, Bye, Hannah, Hubank, Michael, Gevensleben, Heidrun, Cutts, Ros, Snowdon, Claire, Rea, Daniel, Cameron, David, Shaaban, Abeer, Randle, Katrina, Martin, Sue, Wilkinson, Katie, Moretti, Laura, Bliss, Judith M, Ring, Alistair

“…Circulating tumour DNA (ctDNA) testing might provide a current assessment of the genomic profile of advanced cancer, without the need to repeat tumour biopsy…”
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The impact of medication side effects on adherence and persistence to hormone therapy in breast cancer survivors: A qualitative systematic review and thematic synthesis by Peddie, Nicola, Agnew, Sommer, Crawford, Megan, Dixon, Diane, MacPherson, Iain, Fleming, Leanne

“…Hormone Therapy (HT) reduces the risk of breast cancer recurrence and mortality in women with breast cancer. Despite these clinical benefits, rates of HT…”
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Eribulin, Child-Pugh score, and liver-function tests: lessons from pivotal breast cancer studies 301 and 305 by Macpherson, Iain R, He, Yaohua, Palmieri, Carlo

“…The recommended starting dose of eribulin in patients with hepatic impairment is based on the Child-Pugh score, largely informed by a pharmacokinetic study of…”
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Genomic profile of advanced breast cancer in circulating tumour DNA by Kingston, Belinda, Cutts, Rosalind J., Bye, Hannah, Beaney, Matthew, Walsh-Crestani, Giselle, Hrebien, Sarah, Swift, Claire, Kilburn, Lucy S., Kernaghan, Sarah, Moretti, Laura, Wilkinson, Katie, Wardley, Andrew M., Macpherson, Iain R., Baird, Richard D., Roylance, Rebecca, Reis-Filho, Jorge S., Hubank, Michael, Faull, Iris, Banks, Kimberly C., Lanman, Richard B., Garcia-Murillas, Isaac, Bliss, Judith M., Ring, Alistair, Turner, Nicholas C.

“…The genomics of advanced breast cancer (ABC) has been described through tumour tissue biopsy sequencing, although these approaches are limited by geographical…”
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Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels by Novo, David, Heath, Nikki, Mitchell, Louise, Caligiuri, Giuseppina, MacFarlane, Amanda, Reijmer, Dide, Charlton, Laura, Knight, John, Calka, Monika, McGhee, Ewan, Dornier, Emmanuel, Sumpton, David, Mason, Susan, Echard, Arnaud, Klinkert, Kerstin, Secklehner, Judith, Kruiswijk, Flore, Vousden, Karen, Macpherson, Iain R., Blyth, Karen, Bailey, Peter, Yin, Huabing, Carlin, Leo M., Morton, Jennifer, Zanivan, Sara, Norman, Jim C.

“…Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling…”
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Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells by Dornier, Emmanuel, Rabas, Nicolas, Mitchell, Louise, Novo, David, Dhayade, Sandeep, Marco, Sergi, Mackay, Gillian, Sumpton, David, Pallares, Maria, Nixon, Colin, Blyth, Karen, Macpherson, Iain R., Rainero, Elena, Norman, Jim C.

“…The role of glutaminolysis in providing metabolites to support tumour growth is well-established, but the involvement of glutamine metabolism in invasive…”
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Niraparib for Advanced Breast Cancer with Germline BRCA1 and BRCA2 Mutations: the EORTC 1307-BCG/BIG5-13/TESARO PR-30-50-10-C BRAVO Study by Turner, Nicholas C, Balmaña, Judith, Poncet, Coralie, Goulioti, Theodora, Tryfonidis, Konstantinos, Honkoop, Aafke H, Zoppoli, Gabriele, Razis, Evangelia, Johannsson, Oskar T, Colleoni, Marco, Tutt, Andrew N, Audeh, William, Ignatiadis, Michail, Mailliez, Audrey, Trédan, Olivier, Musolino, Antonino, Vuylsteke, Peter, Juan-Fita, Maria Jose, Macpherson, Iain R J, Kaufman, Bella, Manso, Luis, Goldstein, Lori J, Ellard, Susan L, Láng, István, Jen, Kai Yu, Adam, Virginie, Litière, Saskia, Erban, John, Cameron, David A

“…To investigate the activity of niraparib in patients with germline-mutated (g m) advanced breast cancer. BRAVO was a randomized, open-label phase III trial…”
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The impact of symptom clusters on endocrine therapy adherence in patients with breast cancer by Agnew, Sommer, Crawford, Megan, MacPherson, Iain, Shiramizu, Victor, Fleming, Leanne

“…When taken as prescribed, endocrine therapy is effective in reducing risk of recurrence and mortality in the treatment of patients with breast cancer. However,…”
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Comparing Breast Cancer Multiparameter Tests in the OPTIMA Prelim Trial: No Test Is More Equal Than the Others by Bartlett, John M S, Bayani, Jane, Marshall, Andrea, Dunn, Janet A, Campbell, Amy, Cunningham, Carrie, Sobol, Monika S, Hall, Peter S, Poole, Christopher J, Cameron, David A, Earl, Helena M, Rea, Daniel W, Macpherson, Iain R, Canney, Peter, Francis, Adele, McCabe, Christopher, Pinder, Sarah E, Hughes-Davies, Luke, Makris, Andreas, Stein, Robert C

“…Previous reports identifying discordance between multiparameter tests at the individual patient level have been largely attributed to methodological…”
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The impact of medication side effects on adherence and persistence to hormone therapy in breast cancer survivors: A quantitative systematic review by Fleming, Leanne, Agnew, Sommer, Peddie, Nicola, Crawford, Megan, Dixon, Diane, MacPherson, Iain

“…Hormone Therapy (HT) is recommended for most women with HR-positive primary breast cancer. When taken as intended, HT reduces breast cancer recurrence by 40%…”
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Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity by Hernandez-Fernaud, Juan R., Ruengeler, Elena, Casazza, Andrea, Neilson, Lisa J., Pulleine, Ellie, Santi, Alice, Ismail, Shehab, Lilla, Sergio, Dhayade, Sandeep, MacPherson, Iain R., McNeish, Iain, Ennis, Darren, Ali, Hala, Kugeratski, Fernanda G., Al Khamici, Heba, van den Biggelaar, Maartje, van den Berghe, Peter V.E., Cloix, Catherine, McDonald, Laura, Millan, David, Hoyle, Aoisha, Kuchnio, Anna, Carmeliet, Peter, Valenzuela, Stella M., Blyth, Karen, Yin, Huabing, Mazzone, Massimiliano, Norman, Jim C., Zanivan, Sara

“…The secretome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasion and angiogenesis. Here we compare the secretome…”
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A real-world study of the first use of palbociclib for the treatment of advanced breast cancer within the UK National Health Service as part of the novel Ibrance® Patient Program by Palmieri, Carlo, Musson, Alison, Harper-Wynne, Catherine, Wheatley, Duncan, Bertelli, Gianfilippo, Macpherson, Iain R., Nathan, Mark, McDowall, Ellie, Bhojwani, Ajay, Verrill, Mark, Eva, Joe, Doody, Colm, Chowdhury, Ruhe

“…Background The Ibrance® Patient Program was established to provide access to palbociclib for UK National Health Service (NHS) patients with metastatic breast…”
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A randomised controlled trial of interventions for taxane-induced nail toxicity in women with early breast cancer by Morrison, Audrey, Marshall-McKenna, Rebecca, McFadyen, Angus K., Hutchison, Cathy, Rice, Ann-Marie, Stirling, Lynne, McIlroy, Pauline, Macpherson, Iain R.

“…Onycholysis and paronychia has been associated with chemotherapy treatment for women with breast cancer. Our primary aim was to investigate the effectiveness…”
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A phase I/II study of epertinib plus trastuzumab with or without chemotherapy in patients with HER2-positive metastatic breast cancer by Macpherson, Iain R, Spiliopoulou, Pavlina, Rafii, Saeed, Saggese, Matilde, Baird, Richard D, Garcia-Corbacho, Javier, Italiano, Antoine, Bonneterre, Jacques, Campone, Mario, Cresti, Nicola, Posner, John, Takeda, Yousuke, Arimura, Akinori, Spicer, James

“…Epertinib (S-222611) is a potent reversible inhibitor of HER2, EGFR and HER4. This trial evaluated the safety, tolerability, pharmacokinetics and antitumour…”
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Multicenter, Prospective, Randomized Controlled Trial of High-Sensitivity Cardiac Troponin I-Guided Combination Angiotensin Receptor Blockade and Beta-Blocker Therapy to Prevent Anthracycline Cardiotoxicity: The Cardiac CARE Trial by Henriksen, Peter A, Hall, Peter, MacPherson, Iain R, Joshi, Shruti S, Singh, Trisha, Maclean, Morag, Lewis, Steff, Rodriguez, Aryelly, Fletcher, Alex, Everett, Russell J, Stavert, Harriet, Broom, Angus, Eddie, Lois, Primrose, Lorraine, McVicars, Heather, McKay, Pam, Borley, Annabel, Rowntree, Clare, Lord, Simon, Collins, Graham, Radford, John, Guppy, Amy, Williams, Michelle C, Japp, Alan, Payne, John R, Newby, David E, Mills, Nicholas L, Oikonomidou, Olga, Lang, Ninian N

“…Anthracycline-induced cardiotoxicity has a variable incidence, and the development of left ventricular dysfunction is preceded by elevations in cardiac…”
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CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer by Macpherson, Iain R, Rainero, Elena, Mitchell, Louise E, van den Berghe, Peter V E, Speirs, Claire, Dozynkiewicz, Marta A, Chaudhary, Suman, Kalna, Gabriela, Edwards, Joanne, Timpson, Paul, Norman, Jim C

“…Chloride intracellular channel 3 (CLIC3) drives invasiveness of pancreatic and ovarian cancer by acting in concert with Rab25 to regulate the recycling of α5β1…”
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High Temperature SELMA: Evolution of DNA-Supported Oligomannose Clusters Which Are Tightly Recognized by HIV bnAb 2G12 by Temme, J. Sebastian, MacPherson, Iain S, DeCourcey, John F, Krauss, Isaac J

“…SELMA (SELection with Modified Aptamers) is a directed evolution method which can be used to develop DNA-supported clusters of carbohydrates in which the…”
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