Search Results - "Macmillan, John"

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway by Chiu, Yu-Hsin, MacMillan, John B., Chen, Zhijian J.

“…Type I interferons (IFNs) are important for antiviral and autoimmune responses. Retinoic acid-induced gene I (RIG-I) and mitochondrial antiviral signaling…”
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The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens by Kumar, Aman, Russell, Regan M., Pifer, Reed, Menezes-Garcia, Zelia, Cuesta, Santiago, Narayanan, Sanjeev, MacMillan, John B., Sperandio, Vanessa

“…The gut-brain axis is crucial to microbial-host interactions. The neurotransmitter serotonin is primarily synthesized in the gastrointestinal (GI) tract, where…”
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1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus by Fu, Peng, La, Scott, MacMillan, John B

“…Two new 1,3-oxazin-6-one derivatives (1 and 2) and six new bohemamine-type pyrrolizidine alkaloids (3–8) were isolated from the marine-derived Streptomyces…”
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Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus by Fu, Peng, MacMillan, John B

“…Spithioneines A and B (1 and 2), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a…”
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Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora by Fu, Peng, MacMillan, John B

“…Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and…”
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Nonenzymatic Reactions in Natural Product Formation by Bouthillette, Leah M., Aniebok, Victor, Colosimo, Dominic A., Brumley, David, MacMillan, John B.

“…Biosynthetic mechanisms of natural products primarily depend on systems of protein catalysts. However, within the field of biosynthesis, there are cases in…”
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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan by Wang, Chensu, Niederstrasser, Hanspeter, Douglas, Peter M., Lin, Rueyling, Jaramillo, Juan, Li, Yang, Oswald, Nathaniel W., Zhou, Anwu, McMillan, Elizabeth A., Mendiratta, Saurabh, Wang, Zhaohui, Zhao, Tian, Lin, Zhiqaing, Luo, Min, Huang, Gang, Brekken, Rolf A., Posner, Bruce A., MacMillan, John B., Gao, Jinming, White, Michael A.

“…Drugs that mirror the cellular effects of starvation mimics are considered promising therapeutics for common metabolic disorders, such as obesity, liver…”
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Discovery, Characterization, and Analogue Synthesis of Bohemamine Dimers Generated by Non-enzymatic Biosynthesis by Fu, Peng, Legako, Aaron, La, Scott, MacMillan, John B.

“…Dibohemamines A–C (5–7), three new dimeric bohemamine analogues dimerized through a methylene group, were isolated from a marine‐derived Streptomyces…”
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Erythrazoles A–B, Cytotoxic Benzothiazoles from a Marine-Derived Erythrobacter sp by Hu, Youcai, MacMillan, John B

“…Chemical examination of an extract from an Erythrobacter sp. isolated from mangrove sediments yielded erythrazoles A (1) and B (2). The erythrazoles are of…”
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Hunanamycin A, an Antibiotic from a Marine-Derived Bacillus hunanensis by Hu, Youcai, Wang, Kezhan, MacMillan, John B

“…Hunanamycin A, the first natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin…”
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Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1 by Sun, Qingxiang, Carrasco, Yazmin P., Hu, Youcai, Guo, Xiaofeng, Mirzaei, Hamid, MacMillan, John, Chook, Yuh Min

“…The polyketide natural product Leptomycin B inhibits nuclear export mediated by the karyopherin protein chromosomal region maintenance 1 (CRM1). Here, we…”
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Synthesis and Investigation of the Abiotic Formation of Pyonitrins A–D by Shingare, Rahul D, Aniebok, Victor, Lee, Hsiau-Wei, MacMillan, John B

“…Pyonitrins A–D are recently isolated natural products from the insect-associated Pseudomonas protegens strain, which were isolated from complex fractions that…”
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Daryamide Analogues from a Marine-Derived Streptomyces species by Fu, Peng, La, Scott, MacMillan, John B

“…Three new cyclohexene amine derivatives, daryamides D–F (1–3), a new arylamine derivative, carpatamide D (4), and a new ornithine lactamization derivative,…”
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Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents by Shingare, Rahul D., MacMillan, John B., Reddy, D. Srinivasa

“…Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here…”
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A method for campus-wide SARS-CoV-2 surveillance at a large public university by Chang, Terren, Draper, Jolene M, Van den Bout, Anouk, Kephart, Ellen, Maul-Newby, Hannah, Vasquez, Yvonne, Woodbury, Jason, Randi, Savanna, Pedersen, Martina, Nave, Maeve, La, Scott, Gallagher, Natalie, McCabe, Molly M, Dhillon, Namrita, Bjork, Isabel, Luttrell, Michael, Dang, Frank, MacMillan, John B, Green, Ralph, Miller, Elizabeth, Kilpatrick, Auston M, Vaske, Olena, Stone, Michael D, Sanford, Jeremy R

“…The systematic screening of asymptomatic and pre-symptomatic individuals is a powerful tool for controlling community transmission of infectious disease on…”
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Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp by Fu, Peng, Jamison, Matthew, La, Scott, MacMillan, John B

“…Inducamides A–C (1–3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were…”
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Boron NMR as a Method to Screen Natural Product Libraries for B‑Containing Compounds by Macho, Jocelyn M., Blue, Riley M., Lee, Hsiau-Wei, MacMillan, John B.

“…Natural products are biologically relevant metabolites exploited for biomedicine and biotechnology. The frequent reisolation of known natural products…”
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Ikarugamycin: A Natural Product Inhibitor of Clathrin‐Mediated Endocytosis by Elkin, Sarah R., Oswald, Nathaniel W., Reed, Dana K., Mettlen, Marcel, MacMillan, John B., Schmid, Sandra L.

“…Ikarugamycin (IKA) is a previously discovered antibiotic, which has been shown to inhibit the uptake of oxidized low‐density lipoproteins in macrophages…”
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Genome-wide association analysis and accuracy of genome-enabled breeding value predictions for resistance to infectious hematopoietic necrosis virus in a commercial rainbow trout breeding population by Vallejo, Roger L, Cheng, Hao, Fragomeni, Breno O, Shewbridge, Kristy L, Gao, Guangtu, MacMillan, John R, Towner, Richard, Palti, Yniv

“…Infectious hematopoietic necrosis (IHN) is a disease of salmonid fish that is caused by the IHN virus (IHNV). Under intensive aquaculture conditions, IHNV can…”
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Detailed Mechanistic Study of the Non-enzymatic Formation of the Discoipyrrole Family of Natural Products by Colosimo, Dominic A, MacMillan, John B

“…Discoipyrroles A–D (DPA–DPD) are recently discovered natural products produced by the marine bacterium Bacillus hunanensis that exhibit anticancer properties…”
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