Search Results - "Maclntyre, D. Euan"

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists by Bakshi, Raman K., Hong, Qingmei, Olson, J.T., Ye, Zhixiong, Sebhat, Iyassue K., Weinberg, David H., MacNeil, Tanya, Kalyani, Rubana N., Tang, Rui, Martin, William J., Strack, Alison, McGowan, Erin, Tamvakopoulos, Constantin, Miller, Randy R., Stearns, Ralph A., Tang, Wei, Maclntyre, D. Euan, van der Ploeg, Lex H.T., Patchett, Arthur A., Nargund, Ravi P.

“…The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described. The discovery…”
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1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia by Anandan, Sampath-Kumar, Webb, Heather Kay, Chen, Dawn, Wang, Yi-Xin (Jim), Aavula, Basker R., Cases, Sylvaine, Cheng, Ying, Do, Zung N., Mehra, Upasana, Tran, Vinh, Vincelette, Jon, Waszczuk, Joanna, White, Kathy, Wong, Kenneth R., Zhang, Le-Ning, Jones, Paul D., Hammock, Bruce D., Patel, Dinesh V., Whitcomb, Randall, MacIntyre, D. Euan, Sabry, James, Gless, Richard

“…1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) attenuated the enhanced glucose excursion following an intraperitoneal glucose tolerance test and…”
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Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats by Shearman, Lauren P., Camacho, Ramon E., Sloan Stribling, D., Zhou, Dan, Bednarek, Maria A., Hreniuk, Donna L., Feighner, Scott D., Tan, Carina P., Howard, Andrew D., Van der Ploeg, Lex H.T., MacIntyre, D.Euan, Hickey, Gerard J., Strack, Alison M.

“…Central administration of the neuropeptide melanin-concentrating hormone (MCH) stimulates feeding in rodents. We studied the effects of intracerebroventricular…”
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Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents by SHEARMAN, Lauren P, SLOAN STRIBLING, D, SPANN, Stephanie K, MACNEIL, Douglas J, FONG, Tung M, METZGER, Joseph M, GOULET, Mark T, HAGMANN, William K, PLUMMER, Christopher W, FINKE, Paul E, MILLS, Sander G, SHAH, Shrenik K, CAMACHO, Ramon E, TRUONG, Quang, VAN DER PLOEG, L. H. T, EUAN MACINTYRE, D, STRACK, Alison M, ROSKO, Kimberly M, JUNYING WANG, TONG, Sharon, YUE FENG, MARSH, Donald J, HONG YU, XIAOMING GUAN

“…We document in vitro and in vivo effects of a novel, selective cannabinoid CB(1) receptor inverse agonist, Imidazole 24b…”
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Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives by Meurer, Laura C., Finke, Paul E., Owens, Karen A., Tsou, Nancy N., Ball, Richard G., Mills, Sander G., MacCoss, Malcolm, Sadowski, Sharon, Cascieri, Margaret A., Tsao, Kwei-Lan, Chicchi, Gary G., Egger, Linda A., Luell, Silvi, Metzger, Joseph M., MacIntyre, D. Euan, Rupniak, Nadia M.J., Williams, Angela R., Hargreaves, Richard J.

“…The optimization of a cyclopentane-based hNK1 antagonist scaffold will be discussed in the context of enhanced water-solubility, sub-nanomolar hNK1 binding…”
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Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase by Guthikonda, Ravindra N., Shah, Shrenik K., Pacholok, Stephen G., Humes, John L., Mumford, Richard A., Grant, Stephan K., Chabin, Renee M., Green, Barbara G., Tsou, Nancy, Ball, Richard, Fletcher, Daniel S., Luell, Silvi, Euan MacIntyre, D., MacCoss, Malcolm

“…The synthesis and nitric oxide synthase inhibitory activity of bicyclic amidines are described. The 6,6 and 5,6 fused amidines 8a and 10a are potent,…”
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