Search Results - "Macleod, Olivia J S"
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Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor
Published in Nature communications (29-08-2022)“…African trypanosomes are extracellular pathogens of mammals and are exposed to the adaptive and innate immune systems. Trypanosomes evade the adaptive immune…”
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A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis
Published in PLoS neglected tropical diseases (01-05-2019)“…Infections of humans and livestock with African trypanosomes are treated with drugs introduced decades ago that are not always fully effective and often have…”
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3
How Does the VSG Coat of Bloodstream Form African Trypanosomes Interact with External Proteins?
Published in PLoS pathogens (01-12-2015)“…Variations on the statement "the variant surface glycoprotein (VSG) coat that covers the external face of the mammalian bloodstream form of Trypanosoma brucei…”
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4
Black-necked spitting cobra (Naja nigricollis) phospholipases A2 may cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket
Published in Scientific reports (16-04-2022)“…African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals…”
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Journal Article -
5
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
Published in Nature communications (12-03-2020)“…Persistent pathogens have evolved to avoid elimination by the mammalian immune system including mechanisms to evade complement. Infections with African…”
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Journal Article -
6
Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor
Published in eLife (15-04-2016)“…The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the…”
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7
In silico identification of Theileria parva surface proteins
Published in Cell surface (Amsterdam) (01-12-2022)“…East Coast Fever is a devastating African cattle disease caused by the apicomplexan parasite, Theileria parva. Little is known about the cell surface, and few…”
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Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion
Published in Nature microbiology (01-12-2019)“…To maintain prolonged infection of mammals, African trypanosomes have evolved remarkable surface coats and a system of antigenic variation 1 . Within these…”
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Journal Article -
9
Black-necked spitting cobra (Naja nigricollis) phospholipases A 2 may cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket
Published in Scientific reports (16-04-2022)“…African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals…”
Get full text
Journal Article -
10
How Does the VSG Coat of Bloodstream Form African Trypanosomes Interact with External Proteins?: e1005259
Published in PLoS Pathogens (01-12-2015)“…Variations on the statement "the variant surface glycoprotein (VSG) coat that covers the external face of the mammalian bloodstream form of Trypanosoma brucei…”
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