Search Results - "Maclean, R. Craig"

The evolution of antibiotic resistance by MacLean, R Craig, San Millan, Alvaro

“…Clinically relevant evolution studies are needed to help fight the spread of antibiotic resistance For most of human history, bacterial pathogens have been a…”
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CRISPR-Cas systems restrict horizontal gene transfer in Pseudomonas aeruginosa by Wheatley, Rachel M., MacLean, R. Craig

“…CRISPR-Cas systems provide bacteria and archaea with an adaptive immune system that targets foreign DNA. However, the xenogenic nature of immunity provided by…”
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Beyond horizontal gene transfer: the role of plasmids in bacterial evolution by Rodríguez-Beltrán, Jerónimo, DelaFuente, Javier, León-Sampedro, Ricardo, MacLean, R. Craig, San Millán, Álvaro

“…Plasmids have a key role in bacterial ecology and evolution because they mobilize accessory genes by horizontal gene transfer. However, recent studies have…”
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Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates by Papkou, Andrei, Hedge, Jessica, Kapel, Natalia, Young, Bernadette, MacLean, R. Craig

“…The rise of antibiotic resistance in many bacterial pathogens has been driven by the spread of a few successful strains, suggesting that some bacteria are…”
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Stochastic bacterial population dynamics restrict the establishment of antibiotic resistance from single cells by Alexander, Helen K., MacLean, R. Craig

“…A better understanding of how antibiotic exposure impacts the evolution of resistance in bacterial populations is crucial for designing more sustainable…”
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The genetic basis of the fitness costs of antimicrobial resistance: a meta‐analysis approach by Vogwill, Tom, MacLean, R. Craig

“…The evolution of antibiotic resistance carries a fitness cost, expressed in terms of reduced competitive ability in the absence of antibiotics. This cost plays…”
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Fitness Costs of Plasmids: a Limit to Plasmid Transmission by San Millan, Alvaro, MacLean, R Craig

“…Plasmids mediate the horizontal transmission of genetic information between bacteria, facilitating their adaptation to multiple environmental conditions. An…”
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Integron activity accelerates the evolution of antibiotic resistance by Souque, Célia, Escudero, José Antonio, MacLean, R Craig

“…Mobile integrons are widespread genetic platforms that allow bacteria to modulate the expression of antibiotic resistance cassettes by shuffling their position…”
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Staphylococcal phages and pathogenicity islands drive plasmid evolution by Humphrey, Suzanne, San Millán, Álvaro, Toll-Riera, Macarena, Connolly, John, Flor-Duro, Alejandra, Chen, John, Ubeda, Carles, MacLean, R. Craig, Penadés, José R.

“…Conjugation has classically been considered the main mechanism driving plasmid transfer in nature. Yet bacteria frequently carry so-called non-transmissible…”
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Interactions between horizontally acquired genes create a fitness cost in Pseudomonas aeruginosa by San Millan, Alvaro, Toll-Riera, Macarena, Qi, Qin, MacLean, R. Craig

“…Horizontal gene transfer (HGT) plays a key role in bacterial evolution, especially with respect to antibiotic resistance. Fitness costs associated with mobile…”
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The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts by MacLean, R. Craig, Hall, Alex R, Perron, Gabriel G, Buckling, Angus

“…Key Points The fitness effects of antibiotic-resistance mutations and of mutations that compensate for the cost of resistance depends on the molecular basis of…”
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Microbial Evolution: Towards Resolving the Plasmid Paradox by MacLean, R. Craig, San Millan, Alvaro

“…Plasmids play a key role in bacterial evolution by providing bacteria with new and important functions, such as antibiotic resistance. New research shows how…”
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Positive epistasis between co-infecting plasmids promotes plasmid survival in bacterial populations by San Millan, Alvaro, Heilbron, Karl, MacLean, R Craig

“…Plasmids have a key role in the horizontal transfer of genes among bacteria. Although plasmids are catalysts for bacterial evolution, it is challenging to…”
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The Beagle in a bottle by Buckling, Angus, Craig Maclean, R, Brockhurst, Michael A, Colegrave, Nick

“…Why infer evolution when you can watch it happen in real time? This is the basic premise of using populations of fast-replicating microorganisms in test tubes…”
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Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient by Wheatley, Rachel M., Caballero, Julio Diaz, van der Schalk, Thomas E., De Winter, Fien H. R., Shaw, Liam P., Kapel, Natalia, Recanatini, Claudia, Timbermont, Leen, Kluytmans, Jan, Esser, Mark, Lacoma, Alicia, Prat-Aymerich, Cristina, Oliver, Antonio, Kumar-Singh, Samir, Malhotra-Kumar, Surbhi, Craig MacLean, R.

“…Bacteria have the potential to translocate between sites in the human body, but the dynamics and consequences of within-host bacterial migration remain poorly…”
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Cooperation, competition and antibiotic resistance in bacterial colonies by Frost, Isabel, Smith, William P. J., Mitri, Sara, Millan, Alvaro San, Davit, Yohan, Osborne, James M., Pitt-Francis, Joe M., MacLean, R. Craig, Foster, Kevin R.

“…Bacteria commonly live in dense and genetically diverse communities associated with surfaces. In these communities, competition for resources and space is…”
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Evaluating evolutionary models of stress-induced mutagenesis in bacteria by MacLean, R. Craig, Torres-Barceló, Clara, Moxon, Richard

“…In this Opinion article, the authors discuss models that could explain the evolution of stress-induced mutagenesis in bacteria. They include a new model that…”
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Off-Target Integron Activity Leads to Rapid Plasmid Compensatory Evolution in Response to Antibiotic Selection Pressure by Souque, Célia, Escudero, José A, MacLean, R Craig

“…Integrons are mobile genetic elements that have played an important role in the dissemination of antibiotic resistance. Under stress, the integron can generate…”
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Integrative analysis of fitness and metabolic effects of plasmids in Pseudomonas aeruginosa PAO1 by San Millan, Alvaro, Toll-Riera, Macarena, Qi, Qin, Betts, Alex, Hopkinson, Richard J., McCullagh, James, MacLean, R. Craig

“…Horizontal gene transfer (HGT) mediated by the spread of plasmids fuels evolution in prokaryotes. Although plasmids provide bacteria with new adaptive genes,…”
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Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients by Diaz Caballero, Julio, Wheatley, Rachel M., Kapel, Natalia, López-Causapé, Carla, Van der Schalk, Thomas, Quinn, Angus, Shaw, Liam P., Ogunlana, Lois, Recanatini, Claudia, Xavier, Basil Britto, Timbermont, Leen, Kluytmans, Jan, Ruzin, Alexey, Esser, Mark, Malhotra-Kumar, Surbhi, Oliver, Antonio, MacLean, R. Craig

“…Antibiotic resistance poses a global health threat, but the within-host drivers of resistance remain poorly understood. Pathogen populations are often assumed…”
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