Search Results - "Maclean, K N"

Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice by Kern, D S, Maclean, K N, Jiang, H, Synder, E Y, Sladek, Jr, J R, Bjugstad, K B

“…Tau accumulation, in the form of neurofibrillary tangles (NFT), is an early neuropathological characteristic of Alzheimer's disease (AD) and early onset AD…”
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Regulation of Human Cystathionine β-Synthase by S-Adenosyl-l-methionine:  Evidence for Two Catalytically Active Conformations Involving an Autoinhibitory Domain in the C-Terminal Region by Janošík, Miroslav, Kery, Vladimír, Gaustadnes, Mette, Maclean, Kenneth N, Kraus, Jan P

“…Cystathionine β-synthase (CBS), condensing homocysteine and serine, represents a key regulatory point in the biosynthesis of cysteine via the transsulfuration…”
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The Human Cystathionine β-Synthase (CBS) Gene: Complete Sequence, Alternative Splicing, and Polymorphisms by Kraus, Jan P., Oliveriusová, Jana, Sokolová, Jitka, Kraus, Eva, Vlček, Čestmı&́r, de Franchis, Raffaella, Maclean, Kenneth N., Bao, Liming, Bukovská, Gabriela, Patterson, David, Pačes, Václav, Ansorge, Wilhelm, Kožich, Viktor

“…Cystathionine β-synthase [CBS;l-serine hydro-lyase (adding homocysteine), EC 4.2.1.22] catalyzes the first committed step of transsulfuration and is the enzyme…”
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Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia by Schwahn, B.C, Wang, X.-L, Mikael, L.G, Wu, Q, Cohn, J, Jiang, H, Maclean, K.N, Rozen, R

“…Abstract Objective To investigate the lipotropic action of betaine on plasma lipoproteins and tissue lipids. Methods and results Adult mice, wild type (+/+) or…”
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The Dominant Role of Sp1 in Regulating the Cystathionine β-Synthase –1a and –1b Promoters Facilitates Potential Tissue-specific Regulation by Kruppel-like Factors by Maclean, Kenneth N., Kraus, Eva, Kraus, Jan P.

“…Cystathionine β-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between…”
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The human immediate early gene BRF1 maps to chromosome 14q22-q24 by MACLEAN, K. N, SEE, C. G, MCKAY, I. A, BUSTIN, S. A

“…BRF1 (Butyrate response factor 1) is a member of an immediate early gene family specifying putative nuclear transcription factors. A repeat motif incorporating…”
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Transsulfuration in Saccharomyces cerevisiae is not dependent on heme: purification and characterization of recombinant yeast cystathionine β-synthase by Maclean, Kenneth N, Janošı́k, Miroslav, Oliveriusová, Jana, Kery, Vladimı́r, Kraus, Jan P

“…Cystathionine β-synthase [CBS; l-serine hydro-lyase (adding homocysteine), EC 4.2.1.22] catalyzes the first committed step of transsulfuration in both yeast…”
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Evidence for Social Anxiety and Impaired Social Cognition in a Mouse Model of Fragile X Syndrome by McNaughton, Caitlyn H, Moon, Jisook, Strawderman, Myla S, Maclean, Kenneth N, Evans, Jeffrey, Strupp, Barbara J

“…This study assessed social behavior in a mouse model of Fragile X syndrome (FXS), the Fmr1 tm1Cgr or Fmr1 "knockout" (KO) mouse. Both the KO and wild-type (WT)…”
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Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells by Maclean, K N, McKay, I A, Bustin, S A

“…The tetradecanoyl phorbol acetate (TPA)-inducible sequence 11 (TIS11) family of early-response proteins consists of at least five members. They share a highly…”
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Cystathionine Protects against Endoplasmic Reticulum Stress-induced Lipid Accumulation, Tissue Injury, and Apoptotic Cell Death by Maclean, Kenneth N., Greiner, Lori S., Evans, Jeffrey R., Sood, Sudesh K., Lhotak, Sarka, Markham, Neil E., Stabler, Sally P., Allen, Robert H., Austin, Richard C., Balasubramaniam, Vivek, Jiang, Hua

“…Cystathionine (R-S-(2-amino-2-carboxyethyl)-l-homocysteine) is a non-proteinogenic thioether containing amino acid. In mammals, cystathionine is formed as an…”
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Deletion Mutagenesis of Human Cystathionine [beta]-Synthase. IMPACT ON ACTIVITY, OLIGOMERIC STATUS, AND S-ADENOSYLMETHIONINE REGULATION by Oliveriusova, J, Kery, V, Maclean, K N, Kraus, J P

“…Cystathionine [beta]-synthase is a tetrameric hemeprotein that catalyzes the pyridoxal 5'-phosphate-dependent condensation of serine and homocysteine to…”
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Hormonal regulation of cystathionine beta-synthase expression in liver by Ratnam, Shobhitha, Maclean, Kenneth N, Jacobs, Rene L, Brosnan, Margaret E, Kraus, Jan P, Brosnan, John T

“…Homocysteine metabolism is altered in diabetic patients. Cystathionine beta-synthase (CBS), a key enzyme involved in the transsulfuration pathway, which…”
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Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation by Oliveriusová, Jana, Kery, Vladimír, Maclean, Kenneth N, Kraus, Jan P

“…Cystathionine beta-synthase is a tetrameric hemeprotein that catalyzes the pyridoxal 5'-phosphate-dependent condensation of serine and homocysteine to…”
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Endoplasmic Reticulum Stress Increases Glucose-6-Phosphatase and Glucose Cycling in Liver Cells by Wang, Dong, Wei, Yuren, Schmoll, Dieter, Maclean, Kenneth N, Pagliassotti, Michael J

“…Impaired regulation of hepatic glucose production is a characteristic feature of the metabolic syndrome, a cluster of diseases that includes obesity, insulin…”
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High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine β-synthase (CBS) mutations by Maclean, Kenneth N., Gaustadnes, Mette, Oliveriusová, Jana, Janošík, Miroslav, Kraus, Eva, Kožich, Viktor, Kery, Vladimír, Skovby, Flemming, Rüdiger, Niels, Ingerslev, Jørgen, Stabler, Sally P., Allen, Robert H., Kraus, Jan P.

“…Cystathionine β‐synthase (CBS) is a crucial regulator of plasma levels of the thrombogenic amino acid homocysteine (Hcy). Homocystinuria due to CBS deficiency…”
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Cystathionine β-synthase is coordinately regulated with proliferation through a redox-sensitive mechanism in cultured human cells and Saccharomyces cerevisiae by Maclean, Kenneth N., Janošík, Miroslav, Kraus, Eva, Kožich, Viktor, Allen, Robert H., Raab, Beverly K., Kraus, Jan P.

“…Cystathionine β‐synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between…”
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Plasma albumin cysteinylation is regulated by cystathionine β-synthase by Bar-Or, David, Curtis, C. Gerald, Sullivan, Andrea, Rael, Leonard T., Thomas, Gregory W., Craun, Michael, Bar-Or, Raphael, Maclean, Kenneth N., Kraus, Jan P.

“…High homocysteine (Hcy) levels are a well-known independent risk factor for endothelial damage in atherosclerosis. We examined whether a rat intestinal model…”
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ERF-2, the human homologue of the murine Tis11d early response gene by Nie, Xiao-Feng, Maclean, Kenneth N., Kumar, Vijay, McKay, Ian A., Bustin, Stephen A.

“…A human cDNA specifying a member of the Tis11 early response gene family was cloned and sequenced. The human gene differs from its mouse homologue by encoding…”
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Propionic acidemia: Analysis of mutant propionyl-CoA carboxylase enzymes expressed in Escherichia coli by Chloupkova, Maja, Maclean, Kenneth N., Alkhateeb, Asem, Kraus, Jan P.

“…Deficiency of propionyl‐CoA carboxylase (PCC) results in propionic acidemia, an autosomal recessive disorder characterized by ketoacidosis sufficiently severe…”
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