Search Results - "Maclauchlin, Chris"

Endosomal escape for intracellular delivery of RNA therapeutics: current and future strategies by MacLauchlin, Chris

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Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling by Woodhead, Jeffrey L., Yang, Kyunghee, Oldach, David, MacLauchlin, Chris, Fernandes, Prabhavathi, Watkins, Paul B., Siler, Scott Q., Howell, Brett A.

“…Purpose Macrolide antibiotics are commonly prescribed treatments for drug-resistant bacterial infections; however, many macrolides have been shown to cause…”
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The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N -Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human by McDougall, Robin, Ramsden, Diane, Agarwal, Sagar, Agarwal, Saket, Aluri, Krishna, Arciprete, Michael, Brown, Christopher, Castellanos-Rizaldos, Elena, Charisse, Klaus, Chong, Saeho, Cichocki, Joseph, Fitzgerald, Kevin, Goel, Varun, Gu, Yongli, Guenther, Dale, Habtemariam, Bahru, Jadhav, Vasant, Janas, Maja, Jayaraman, Muthusamy, Kurz, Jeffrey, Li, Jing, Liu, Ju, Liu, Xiumin, Liou, Steven, Maclauchlin, Chris, Maier, Martin, Manoharan, Muthiah, Nair, Jayaprakash K, Robbie, Gabriel, Schmidt, Karyn, Smith, Peter, Theile, Christopher, Vaishnaw, Akshay, Waldron, Scott, Xu, Yuanxin, Zhang, Xuemei, Zlatev, Ivan, Wu, Jing-Tao

“…Conjugation of oligonucleotide therapeutics, including small interfering RNAs (siRNAs) or antisense oligonucleotides, to -acetylgalactosamine (GalNAc) ligands…”
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A Randomized Study Evaluating Oral Fusidic Acid (CEM-102) in Combination With Oral Rifampin Compared With Standard-of-Care Antibiotics for Treatment of Prosthetic Joint Infections: A Newly Identified Drug-Drug Interaction by Pushkin, Richard, Iglesias-Ussel, Maria D., Keedy, Kara, MacLauchlin, Chris, Mould, Diane R., Berkowitz, Richard, Kreuzer, Stephan, Darouiche, Rabih, Oldach, David, Fernandes, Prabha

“…Background. Fusidic acid (FA) has been used for decades for bone infection, including prosthetic joint infection (PJI), often in combination with rifampin…”
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Biotransformation research advances - 2022 year in review by Khojasteh, S Cyrus, Argikar, Upendra A, Cheruzel, Lionel, Cho, Sungjoon, Crouch, Rachel D, Dhaware, Deepika, Heck, Carley J S, Johnson, Kevin M, Kalgutkar, Amit S, King, Lloyd, Liu, Joyce, Ma, Bin, Maw, Hlaing, Miller, Grover P, Seneviratne, Herana Kamal, Takahashi, Ryan H, Wang, Shuai, Wei, Cong, Jackson, Klarissa D

“…This annual review is the eighth of its kind since 2016 (Baillie et al. 2016, Khojasteh et al. 2017, Khojasteh et al. 2018, Khojasteh et al. 2019, Khojasteh…”
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Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics by Ramsden, Diane, Belair, David G, Agarwal, Saket, Andersson, Patrik, Humphreys, Sara, Dalmas, Deidre A, Stahl, Simone H, Maclauchlin, Chris, Cichocki, Joseph A

“…Oligonucleotide therapeutics (ONTs) encompass classes of medicines that selectively target and potentially ameliorate previously untreatable and often rare…”
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