Search Results - "Macklon, Nick"

Recurrent implantation failure is a pathology with a specific transcriptomic signature by Macklon, Nick, M.D., Ph.D

“…Recurrent implantation failure (RIF) is a source of distress and frustration to both patients and their clinicians. In the absence of clinically useful tests,…”
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The human endometrium as a sensor of embryo quality by Macklon, Nick S, Brosens, Jan J

“…Human reproduction is characterized by a high degree of embryo wastage, which is largely ascribed to a high prevalence of embryo aneuploidy. It is proposed…”
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The true incidence of recurrent implantation failure by Macklon, Nick S.

“…To review the merits and limitations of current definitions of recurrent implantation failure (RIF), how they translate into estimates of incidence and to…”
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Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss by Salker, Madhuri, Teklenburg, Gijs, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J, Lokugamage, Amali U, Rai, Raj, Landles, Christian, Roelen, Bernard A J, Quenby, Siobhan, Kuijk, Ewart W, Kavelaars, Annemieke, Heijnen, Cobi J, Regan, Lesley, Macklon, Nick S, Brosens, Jan J

“…Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages, is widely attributed either to repeated chromosomal instability in the conceptus…”
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Immune modulation treatments—where is the evidence? by Hviid, Malene Meisner, M.D, Macklon, Nick, M.D., Ph.D

“…While advances in assisted reproductive techniques have been substantial, failure of the apparently viable embryo to implant remains a source of distress and…”
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Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation by Teklenburg, Gijs, Salker, Madhuri, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J, Lokugamage, Amali U, Rai, Raj, Landles, Christian, Roelen, Bernard A J, Quenby, Siobhan, Kuijk, Ewart W, Kavelaars, Annemieke, Heijnen, Cobi J, Regan, Lesley, Brosens, Jan J, Macklon, Nick S

“…Pregnancy is widely viewed as dependent upon an intimate dialogue, mediated by locally secreted factors between a developmentally competent embryo and a…”
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Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment by Mourik, Maaike S. M., Macklon, Nick S., Heijnen, Cobi J.

“…Successful implantation is an absolute requirement for the reproduction of species, including humans. The process by which a foreign blastocyst is accepted by…”
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Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss by Ng, Ka Ying Bonnie, Cherian, George, Kermack, Alexandra J., Bailey, Sarah, Macklon, Nick, Sunkara, Sesh K., Cheong, Ying

“…It is known that lifestyle factors affect sporadic miscarriage, but the extent of this on RPL (recurrent pregnancy loss) is less well known. A systematic…”
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Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos by Weimar, Charlotte H E, Kavelaars, Annemieke, Brosens, Jan J, Gellersen, Birgit, de Vreeden-Elbertse, Johanna M T, Heijnen, Cobi J, Macklon, Nick S

“…The aetiology of recurrent miscarriage (RM) remains largely unexplained. Women with RM have a shorter time to pregnancy interval than normally fertile women,…”
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What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis by Groenewoud, Eva R, Cantineau, Astrid E P, Kollen, Boudewijn J, Macklon, Nick S, Cohlen, Ben J

“…BACKGROUND Frozen-thawed embryo transfer (FET) enables surplus embryos derived from IVF or IVF-ICSI treatment to be stored and transferred at a later date. In…”
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Uterine Selection of Human Embryos at Implantation by Brosens, Jan J., Salker, Madhuri S., Teklenburg, Gijs, Nautiyal, Jaya, Salter, Scarlett, Lucas, Emma S., Steel, Jennifer H., Christian, Mark, Chan, Yi-Wah, Boomsma, Carolien M., Moore, Jonathan D., Hartshorne, Geraldine M., Šućurović, Sandra, Mulac-Jericevic, Biserka, Heijnen, Cobi J., Quenby, Siobhan, Groot Koerkamp, Marian J., Holstege, Frank C. P., Shmygol, Anatoly, Macklon, Nick S.

“…Human embryos frequently harbor large-scale complex chromosomal errors that impede normal development. Affected embryos may fail to implant although many first…”
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The impact of ovarian stimulation for IVF on the developing embryo by Santos, Margarida Avo, Kuijk, Ewart W, Macklon, Nick S

“…The use of assisted reproductive technologies (ART) has been increasing over the past three decades, and, in developed countries, ART account for 1–3% of…”
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An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF by Koot, Yvonne E. M., van Hooff, Sander R., Boomsma, Carolien M., van Leenen, Dik, Groot Koerkamp, Marian J. A., Goddijn, Mariëtte, Eijkemans, Marinus J. C., Fauser, Bart C. J. M., Holstege, Frank C. P., Macklon, Nick S.

“…The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples…”
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The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy by Vujkovic, Marijana, B.Sc, de Vries, Jeanne H., Ph.D, Lindemans, Jan, Ph.D, Macklon, Nick S., Ph.D, van der Spek, Peter J., Ph.D, Steegers, Eric A.P., Ph.D, Steegers-Theunissen, Régine P.M., Ph.D

“…Objective To investigate associations between preconception dietary patterns and IVF/intracytoplasmic sperm injection (ICSI) outcomes validated by biomarkers…”
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Antimüllerian hormone: prediction of cumulative live birth in gonadotropin-releasing hormone antagonist treatment for in vitro fertilization by Hamdine, Ouijdane, M.D., Ph.D, Eijkemans, Marinus J.C., Ph.D, Lentjes, Eef G.W., Ph.D, Torrance, Helen L., M.D., Ph.D, Macklon, Nick S., M.D., Ph.D, Fauser, Bart C.J.M., M.D., Ph.D, Broekmans, Frank J., M.D., Ph.D

“…Objective To assess the accuracy of antimüllerian hormone (AMH) in predicting cumulative live birth rate (CLBR) within 1 year after treatment initiation in…”
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Peri-implantation glucocorticoid administration for assisted reproductive technology cycles by Boomsma, Carolien M, Keay, Stephen D, Macklon, Nick S

“…In order to improve embryo implantation for in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) cycles the use of glucocorticoids has been…”
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Effect of a 6-week “Mediterranean” dietary intervention on in vitro human embryo development: the Preconception Dietary Supplements in Assisted Reproduction double-blinded randomized controlled trial by Kermack, Alexandra J., Lowen, Philippa, Wellstead, Susan J., Fisk, Helena L., Montag, Markus, Cheong, Ying, Osmond, Clive, Houghton, Franchesca D., Calder, Philip C., Macklon, Nick S.

“…To study the impact of increased dietary intake of omega-3 fatty acids, vitamin D, and olive oil for 6 weeks before in vitro fertilization (IVF) or…”
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The motile and invasive capacity of human endometrial stromal cells: implications for normal and impaired reproductive function by Weimar, Charlotte H E, Macklon, Nick S, Post Uiterweer, Emiel D, Brosens, Jan J, Gellersen, Birgit

“…BACKGROUND Mechanisms underlying early reproductive loss in the human are beginning to be elucidated. The migratory and invasive capacity of human endometrial…”
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Double vitrification and warming of blastocysts does not affect pregnancy, miscarriage or live birth rates by Al Hashimi, Balsam, Linara-Demakakou, Elena, Harvey, Simon C, Harvey, Katie E, Griffin, Darren K, Ahuja, Kamal, Macklon, Nick S

“…Does double blastocyst vitrification and warming affect pregnancy, miscarriage or live birth rates, or birth outcomes, from embryos that have undergone…”
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What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis by Groenewoud, Eva R, Cantineau, Astrid E P, Kollen, Boudewijn J, Macklon, Nick S, Cohlen, Ben J

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