Search Results - "Mackinnon, Sabrina R"

Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase by Blomgren, Linnea K. M., Huber, Melanie, Mackinnon, Sabrina R., Bürer, Céline, Baslé, Arnaud, Yue, Wyatt W., Froese, D. Sean, McCorvie, Thomas J.

“…5,10-methylenetetrahydrofolate reductase (MTHFR) commits folate-derived one-carbon units to generate the methyl-donor s -adenosyl- l -methionine (SAM)…”
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Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening by Mackinnon, Sabrina R, Bezerra, Gustavo A, Krojer, Tobias, Szommer, Tamas, von Delft, Frank, Brennan, Paul E, Yue, Wyatt W

“…Primary hyperoxaluria type I (PH1) is caused by AGXT gene mutations that decrease the functional activity of alanine:glyoxylate aminotransferase. A build-up of…”
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Luminescence-based complementation assay to assess target engagement and cell permeability of glycolate oxidase (HAO1) inhibitors by Mackinnon, Sabrina R., Zarganes-Tzitzikas, Tryfon, Adams, Cassandra J., Brennan, Paul E., Yue, Wyatt W.

“…Glycolate oxidase (HAO1) catalyses the synthesis of glyoxylate, a common metabolic intermediate that causes renal failure if accumulated. HAO1 inhibition is an…”
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Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia by Mackinnon, Sabrina R, Krojer, Tobias, Foster, William R, Diaz-Saez, Laura, Tang, Manshu, Huber, Kilian V. M, von Delft, Frank, Lai, Kent, Brennan, Paul E, Arruda Bezerra, Gustavo, Yue, Wyatt W

“…Classic galactosemia is caused by loss-of-function mutations in galactose-1-phosphate uridylyltransferase (GALT) that lead to toxic accumulation of its…”
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