Search Results - "Mackinnon, A. C."

αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis by Murray, I. R., Gonzalez, Z. N., Baily, J., Dobie, R., Wallace, R. J., Mackinnon, A. C., Smith, J. R., Greenhalgh, S. N., Thompson, A. I., Conroy, K. P., Griggs, D. W., Ruminski, P. G., Gray, G. A., Singh, M., Campbell, M. A., Kendall, T. J., Dai, J., Li, Y., Iredale, J. P., Simpson, H., Huard, J., Péault, B., Henderson, N. C.

“…Mesenchymal cells expressing platelet-derived growth factor receptor beta (PDGFRβ) are known to be important in fibrosis of organs such as the liver and…”
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The therapeutic potential of galectin-3 inhibition in fibrotic disease by Slack, R.J., Mills, R., Mackinnon, A.C.

“…Galectin-3 is a beta-galactoside-binding mammalian lectin and part of the 15 member galectin family that are evolutionarily highly conserved. It is the only…”
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Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure by Henderson, Neil C, Pollock, Katharine J, Frew, John, Mackinnon, Alison C, Flavell, Richard A, Davis, Roger J, Sethi, Tariq, Simpson, Kenneth J

“…Background: Acute hepatic failure secondary to paracetamol poisoning is associated with high mortality. C-jun (NH2) terminal kinase (JNK) is a member of the…”
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Approximate Bayesian computation reveals the factors that influence genetic diversity and population structure of foxsnakes by ROW, J. R., BROOKS, R. J., MacKINNON, C. A., LAWSON, A., CROTHER, B. I., WHITE, M., LOUGHEED, S. C.

“…Contemporary geographical range and patterns of genetic diversity within species reflect complex interactions between multiple factors acting across spatial…”
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ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through β1 integrin-dependent activation of PI3-kinase by Hodkinson, P S, Elliott, T, Wong, W S, Rintoul, R C, Mackinnon, A C, Haslett, C, Sethi, T

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Patients with the worst outcomes after paracetamol (acetaminophen)‐induced liver failure have an early monocytopenia by Moore, J. K., MacKinnon, A. C., Man, T. Y., Manning, J. R., Forbes, S. J., Simpson, K. J.

“…Summary Background Acute liver failure (ALF) is associated with significant morbidity and mortality. Studies have implicated the immune response, especially…”
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Extracellular matrix regulation of drug resistance in small-cell lung cancer by Hodkinson, P. S., Mackinnon, A. C., Sethi, T.

“…Purpose: Lung cancer is the leading cause of cancer deaths in the developed world. Small cell lung cancer (SCLC) has the worst prognosis due to the emergence…”
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ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta 1 integrin-dependent activation of PI3-kinase by Hodkinson, P S, Elliott, T, Wong, W S, Rintoul, R C, Mackinnon, A C, Haslett, C, Sethi, T

“…The emergence of resistance to chemotherapy remains a principle problem in the treatment of small-cell lung cancer (SCLC). We demonstrate that extracellular…”
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Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg , -Trp , Phe ]-substance P (6-11)-induced growth inhibition by WATERS, C. M, MACKINNON, A. C, CUMMINGS, J, TUFAIL-HANIF, U, JODRELL, D, HASLETT, C, SETHI, T

“…[Arg(6),D-Trp(7,9),N(me)Phe(8)]-substance P (6-11) (SP-G) is a novel anticancer agent that has recently completed phase I clinical trials. SP-G inhibits…”
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[Arg ,D-Trp ,N Phe ]-substance P (6-11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism by MACKINNON, A. C, ARMSTRONG, R. A, WATERS, C. M, CUMMINGS, J, SMYTH, J. F, HASLETT, C, SETHI, T

“…[Arg6,D-Trp7,9,NmePhe8]-substance P (6-11) (antagonist G) is a novel class of anti-cancer agent that inhibits small-cell lung cancer (SCLC) cell growth in…”
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[Arg , D-Trp , N Phe ]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy by MACKINNON, A. C, WATERS, C, RAHMAN, I, HARANI, N, RINTOUL, R, HASLETT, C, SETHI, T

“…[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) inhibits small cell lung cancer (SCLC) growth and is entering Phase II clinical…”
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Orbital immunoglobulin IgG4 -related inflammatory fibrosclerosing lesion treated with pentoxifylline and α-tocopherol: case report by Lee, R, MacKinnon, C.A, Aburn, N, Tan, S.T

“…Abstract Immunoglobulin G4 (IgG4 )-related disease is a distinct group of disorders that are characterised by intense infiltration of an organ with IgG4+…”
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MRI FINDINGS IN ACUTE WERNICKE'S ENCEPHALOPATHY by Zhang, L, Benjamin, P, Mackinnon, AC

“…Background Wernicke's encephalopathy (WE) is a neurological emergency due to thiamine deficiency. The clinical triad of ophthalmoplegia, altered consciousness,…”
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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo by Sethi, Tariq, Rintoul, Robert C, Moore, Sarah M, MacKinnon, Alison C, Salter, Donald, Choo, Chin, Chilvers, Edwin R, Dransfield, Ian, Donnelly, Seamas C, Strieter, Robert, Haslett, Christopher

“…Resistance to chemotherapy is a principal problem in the treatment of small cell lung cancer (SCLC). We show here that SCLC is surrounded by an extensive…”
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C. elegans PAT-4/ILK Functions as an Adaptor Protein within Integrin Adhesion Complexes by Mackinnon, A.Craig, Qadota, Hiroshi, Norman, Kenneth R., Moerman, Donald G., Williams, Benjamin D.

“…Background: Mammalian integrin-linked kinase (ILK) was identified in a yeast two-hybrid screen for proteins binding the integrin β1 subunit cytoplasmic domain…”
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[3H]‐RS‐45041‐190: a selective high‐affinity radioligand for I2 imidazoline receptors by MacKinnon, Alison C., Redfern, William S., Brown, Christine M.

“…1 RS‐45041‐190 (4‐chloro‐2‐(imidazolin‐2‐yl)isoindoline) is an I2 imidazoline receptor ligand with the highest affinity and selectivity so far described;…”
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Blindness and severe visual impairment in facial fractures: an 11 year review by MacKinnon, Craig A., David, David J., Cooter, Rodney D.

“…We present an 11 year review of facial fractures treated in the Australian Craniofacial Unit and the Department of Plastic and Reconstructive Surgery at the…”
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HN07PSMOKING CESSATION IN PATIENTS UNDERGOING TREATMENT FOR HEAD AND NECK CANCER by Rajpal, K., Mackinnon, C. A., Tan, S. T.

“…Advice on smoking cessation is part of our overall management for head and neck cancer patients. This study determined the effectiveness of smoking cessation…”
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Alpha 2-adrenoceptor subtypes and imidazoline-like binding sites in the rat brain by Brown, C M, MacKinnon, A C, McGrath, J C, Spedding, M, Kilpatrick, A T

“…1. The binding of [3H]-yohimbine and [3H]-idazoxan to rat cortex and hippocampus is rapid, reversible and of high affinity. Saturation data indicate that a…”
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RS‐45041‐190: a selective, high‐affinity ligand for I2 imidazoline receptors by Brown, C.M., MacKinnon, A.C., Redfern, W.S., Williams, A., Linton, C., Stewart, M., Clague, R.U., Clark, R., Spedding, M.

“…1 RS‐45041‐190 (4‐chloro‐2‐(imidazolin‐2‐yl)isoindoUne) showed high affinity for I2 imidazoline receptors labelled by [3H]‐idazoxan in rat (pKi = 8.66 ±0.09),…”
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