Search Results - "Mackie, Timothy D."

Osmolyte accumulation regulates the SUMOylation and inclusion dynamics of the prionogenic Cyc8-Tup1 transcription corepressor by Nadel, Cory M, Mackie, Timothy D, Gardner, Richard G

“…Environmental stressors can severely perturb cellular homeostasis and compromise viability. To cope with environmental stressors, eukaryotes have developed…”
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Metabolite analysis of Clostridium acetobutylicum: Fermentation in a microbial fuel cell by Finch, Amethist S., Mackie, Timothy D., Sund, Christian J., Sumner, James J.

“…Microbial fuel cells (MFCs) were used to monitor metabolism changes in Clostridium acetobutylicum fermentations. When MFCs were inoculated with C…”
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Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates by Guerriero, Christopher J, Reutter, Karl-Richard, Augustine, Andrew A, Preston, G Michael, Weiberth, Kurt F, Mackie, Timothy D, Cleveland-Rubeor, Hillary C, Bethel, Neville P, Callenberg, Keith M, Nakatsukasa, Kunio, Grabe, Michael, Brodsky, Jeffrey L

“…Integral membrane proteins fold inefficiently and are susceptible to turnover via the endoplasmic reticulum-associated degradation (ERAD) pathway. During ERAD,…”
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Investigating Potassium Channels in Budding Yeast: A Genetic Sandbox by Mackie, Timothy D, Brodsky, Jeffrey L

“…Like all species, the model eukaryote , or Bakers' yeast, concentrates potassium in the cytosol as an electrogenic osmolyte and enzyme cofactor. Yeast are…”
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Endoplasmic reticulum–associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome by O'Donnell, Brighid M., Mackie, Timothy D., Subramanya, Arohan R., Brodsky, Jeffrey L.

“…Type II Bartter syndrome is caused by mutations in the renal outer medullary potassium (ROMK) channel, but the molecular mechanisms underlying this disease are…”
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Characterization of hyperactive mutations in the renal potassium channel ROMK uncovers unique effects on channel biogenesis and ion conductance by Nguyen, Nga H, Sheng, Shaohu, Banerjee, Anupam, Guerriero, Christopher J, Chen, Jingxin, Wang, Xueqi, Mackie, Timothy D, Welling, Paul A, Kleyman, Thomas R, Bahar, Ivet, Carlson, Anne E, Brodsky, Jeffrey L

“…Hypertension affects one billion people worldwide and is the most common risk factor for cardiovascular disease, yet a comprehensive picture of its underlying…”
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Characterization of Hyperactive Mutant forms of the Renal Potassium Channel, ROMK, a Protein Linked to Hypertension by Nguyen, Nga H., Wang, Xueqi, Chen, Jingxin, Mackie, Timothy D., Kleyman, Thomas R., Sheng, Shaohu, Brodsky, Jeffrey L.

“…Hypertension affects one billion people worldwide and is the most common risk factor for cardiovascular disease. Despite the high heritability of hypertension,…”
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Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model by Hager, natalie A., Krasowski, Collin J., Mackie, Timothy D., Kolb, Alexander R., Needham, Patrick G., Augustine, Andrew A., Dempsey, Alison, Szent-Gyorgyi, Christopher, Bruchez, Marcel P., Bain, Daniel J., Kwiatkowski, Adam V., O'Donnell, Allyson F., Brodsky, Jeffrey L.

“…Protein composition at the plasma membrane is tightly regulated, with rapid protein internalization and selective targeting to the cell surface occurring in…”
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The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK) by Mackie, Timothy D., Kim, Bo-Young, Subramanya, Arohan R., Bain, Daniel J., O'Donnell, Allyson F., Welling, Paul A., Brodsky, Jeffrey L.

“…Protein trafficking can act as the primary regulatory mechanism for ion channels with high open probabilities, such as the renal outer medullary (ROMK)…”
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Linking chanelopathies with endoplasmic reticulum associated degradation by O'Donnell, Brighid M., Mackie, Timothy D., Brodsky, Jeffrey L.

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A Screen for Potassium‐sensitivity in Yeast Reveals Endosomal Sorting Factors that Regulate the Renal Outer Medullary Potassium (ROMK) Channel by Mackie, Timothy D., Welling, Paul A., Subramanya, Arohan R., Brodsky, Jeffrey L.

“…Abstract only The renal outer medullary potassium (ROMK) channel is a major route for potassium secretion from distal nephron principal cells in response to…”
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Metabolite analysis of Clostridium acetobutylicum: Fermentation in a microbial fuel cell: Biofuels - II: Algal Biofuels and Microbial Fuel Cells by FINCH, Amethist S, MACKIE, Timothy D, SUND, Christian J, SUMNER, James J

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