Emerging roles of atypical chemokine receptor 3 (ACKR3) in normal development and physiology

Emerging roles of atypical chemokine receptor 3 (ACKR3) in normal development and physiology

The discovery that atypical chemokine receptors (ACKRs) can initiate alternative signaling pathways rather than classical G-protein coupled receptor (GPCR) signaling has changed the paradigm of chemokine receptors and their roles in modulating chemotactic responses. The ACKR family has grown over th...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Vol. 109; pp. 17 - 23
Main Authors: Quinn, K.E., Mackie, D.I., Caron, K.M.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-09-2018
Subjects:
Adrenomedullin
Animals
Atypical chemokine receptor 3/chemokine receptor 7 (ACKR3/CXCR7)
C-X-C motif chemokine ligand 11 (CXCL11)
C-X-C motif chemokine ligand 12 (CXCL12)
Cell Line
Cell Proliferation - physiology
Chemokine CXCL11 - metabolism
Chemokine CXCL12 - metabolism
Chemotaxis - immunology
Embryo Implantation - physiology
Female
HEK293 Cells
Humans
Male
Mice
Physiology
Receptors, CXCR - metabolism
Signal Transduction - physiology
Spermatogenesis - physiology
Vasodilation - physiology
Adrenomedullin
C-X-C motif chemokine ligand 12 (CXCL12)
C-X-C motif chemokine ligand 11 (CXCL11)
Physiology
Atypical chemokine receptor 3/chemokine receptor 7 (ACKR3/CXCR7)
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Summary:The discovery that atypical chemokine receptors (ACKRs) can initiate alternative signaling pathways rather than classical G-protein coupled receptor (GPCR) signaling has changed the paradigm of chemokine receptors and their roles in modulating chemotactic responses. The ACKR family has grown over the years, with discovery of new functions and roles in a variety of pathophysiological conditions. However, the extent to which these receptors regulate normal physiology is still continuously expanding. In particular, atypical chemokine receptor 3 (ACKR3) has proven to be an important receptor in mediating normal biological functions, including cardiac development and migration of cortical neurons. In this review, we illustrate the versatile and intriguing role of ACKR3 in physiology.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2018.02.024