Search Results - "Mackey, Megan"

Nuclear Targeting of Gold Nanoparticles in Cancer Cells Induces DNA Damage, Causing Cytokinesis Arrest and Apoptosis by Kang, Bin, Mackey, Megan A, El-Sayed, Mostafa A

“…By properly conjugating gold nanoparticles with specific peptides, we were successful in selectively transporting them to the nuclei of cancer cells. Confocal…”
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The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery by Austin, Lauren A., Mackey, Megan A., Dreaden, Erik C., El-Sayed, Mostafa A.

“…Nanotechnology is a rapidly growing area of research in part due to its integration into many biomedical applications. Within nanotechnology, gold and silver…”
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The Most Effective Gold Nanorod Size for Plasmonic Photothermal Therapy: Theory and In Vitro Experiments by Mackey, Megan A, Ali, Moustafa R. K, Austin, Lauren A, Near, Rachel D, El-Sayed, Mostafa A

“…The development of new and improved photothermal contrast agents for the successful treatment of cancer (or other diseases) via plasmonic photothermal therapy…”
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Beating cancer in multiple ways using nanogold by Dreaden, Erik C, Mackey, Megan A, Huang, Xiaohua, Kang, Bin, El-Sayed, Mostafa A

“…Gold nanoparticles possess a unique combination of properties which allow them to act as highly multifunctional anti-cancer agents (X. H. Huang, P. K. Jain, I…”
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Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice by Ali, Moustafa R. K., Rahman, Mohammad Aminur, Wu, Yue, Han, Tiegang, Peng, Xianghong, Mackey, Megan A., Wang, Dongsheng, Shin, Hyung Ju, Chen, Zhuo G., Xiao, Haopeng, Wu, Ronghu, Tang, Yan, Shin, Dong M., El-Sayed, Mostafa A.

“…Gold nanorods (AuNRs)-assisted plasmonic photothermal therapy (AuNRs-PPTT) is a promising strategy for combating cancer in which AuNRs absorb near-infrared…”
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Remote Triggered Release of Doxorubicin in Tumors by Synergistic Application of Thermosensitive Liposomes and Gold Nanorods by Agarwal, Abhiruchi, Mackey, Megan A, El-Sayed, Mostafa A, Bellamkonda, Ravi V

“…Delivery of chemotherapeutic agents after encapsulation in nanocarriers such as liposomes diminishes side-effects, as PEGylated nanocarrier pharmacokinetics…”
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Size matters: gold nanoparticles in targeted cancer drug delivery by Dreaden, Erik C, Austin, Lauren A, Mackey, Megan A, El-Sayed, Mostafa A

“…Cancer is the current leading cause of death worldwide, responsible for approximately one quarter of all deaths in the USA and UK. Nanotechnologies provide…”
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Extended-Duration MK-8591-Eluting Implant as a Candidate for HIV Treatment and Prevention by Barrett, Stephanie E, Teller, Ryan S, Forster, Seth P, Li, Li, Mackey, Megan A, Skomski, Daniel, Yang, Zhen, Fillgrove, Kerry L, Doto, Gregory J, Wood, Sandra L, Lebron, Jose, Grobler, Jay A, Sanchez, Rosa I, Liu, Zhen, Lu, Bing, Niu, Tao, Sun, Li, Gindy, Marian E

“…Regimen adherence remains a major hurdle to the success of daily oral drug regimens for the treatment and prevention of human immunodeficiency virus (HIV)…”
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Probing the Unique Dehydration-Induced Structural Modifications in Cancer Cell DNA Using Surface Enhanced Raman Spectroscopy by Panikkanvalappil, Sajanlal R, Mackey, Megan A, El-Sayed, Mostafa A

“…Conformation-induced formation of a series of unique Raman marker bands in cancer cell DNA, upon dehydration, have been probed for the first time with the use…”
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Surface-Enhanced Raman Spectroscopy for Real-Time Monitoring of Reactive Oxygen Species-Induced DNA Damage and Its Prevention by Platinum Nanoparticles by Panikkanvalappil, Sajanlal R, Mahmoud, Mahmoud A, Mackey, Megan A, El-Sayed, Mostafa A

“…We have successfully demonstrated the potential of surface-enhanced Raman spectroscopy (SERS) in monitoring the real time damage to genomic DNA. To reveal the…”
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Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma by KREISI, Teri N, KIM, Lyndon, PARK, John, ALBERT, Paul S, FINE, Howard A, MOORE, Kraig, DUIC, Paul, ROYCE, Cheryl, STROUD, Irene, GARREN, Nancy, MACKEY, Megan, BUTMAN, John A, CAMPHAUSEN, Kevin

“…To evaluate single-agent activity of bevacizumab in patients with recurrent glioblastoma. Patients with recurrent glioblastoma were treated with bevacizumab 10…”
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Development and qualification of an automated capillary Western method for the identification of polysaccharide serotypes in pneumococcal conjugate vaccine (PCV) by Deiss, Alyssa, Loughney, John W., Rustandi, Richard R., Vuolo, Kimberly, Mackey, Megan A.

“…Streptococcus pneumoniae bacterial infection causes mortality in both adults and infants. To mitigate the impact of the disease, several Pneumococcal conjugate…”
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Biological Targeting of Plasmonic Nanoparticles Improves Cellular Imaging via the Enhanced Scattering in the Aggregates Formed by Aioub, Mena, Kang, Bin, Mackey, Megan A, El-Sayed, Mostafa A

“…Gold nanoparticles (AuNPs) demonstrate great promise in biomedical applications due to their plasmonically enhanced imaging properties. When in close…”
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Inducing Cancer Cell Death by Targeting Its Nucleus: Solid Gold Nanospheres versus Hollow Gold Nanocages by Mackey, Megan A, Saira, Farhat, Mahmoud, Mahmoud A, El-Sayed, Mostafa A

“…Recently, we have shown that targeting the cancer cell nucleus with solid gold nanospheres, using a cancer cell penetrating/pro-apoptotic peptide (RGD) and a…”
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Theoretical Modeling and Mechanism of Drug Release from Long-Acting Parenteral Implants by Microstructural Image Characterization by Irizarry, Roberto, Skomski, Daniel, Chen, Antong, Teller, Ryan S, Forster, Seth, Mackey, Megan A, Li, Li

“…This work develops a mechanistic understanding and a simplified model to understand changes in drug release profiles of an active pharmaceutical ingredient in…”
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Chemosensitization of Cancer Cells via Gold Nanoparticle-Induced Cell Cycle Regulation by Mackey, Megan A., El-Sayed, Mostafa A.

“…We have previously shown that plasmonic nanoparticles conjugated with nuclear‐targeting and cytoplasm‐targeting peptides (NLS and RGD, respectively) are…”
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In vitro investigations of gold nanocages: Toxicological profile in human keratinocyte cell line by Saira, Farhat, Mackey, Megan A., Qureshi, Rumana, Mahmoud, Mahmoud A.

“…Gold nanocages (AuNCs) are comparatively novel nanostructures, as many of their characteristics are still to be exploited. The purpose of present study was to…”
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MGMT ProFWise: Unlocking a New Application for Combined Feature Selection and the Rank-Based Weighting Method to Link MGMT Methylation Status to Serum Protein Expression in Patients with Glioblastoma by Tasci, Erdal, Shah, Yajas, Jagasia, Sarisha, Zhuge, Ying, Shephard, Jason, Johnson, Margaret O, Elemento, Olivier, Joyce, Thomas, Chappidi, Shreya, Cooley Zgela, Theresa, Sproull, Mary, Mackey, Megan, Camphausen, Kevin, Krauze, Andra Valentina

“…Glioblastoma (GBM) is a fatal brain tumor with limited treatment options. O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is the…”
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XAV939: From a Small Inhibitor to a Potent Drug Bioconjugate When Delivered by Gold Nanoparticles by Afifi, Marwa M, Austin, Lauren A, Mackey, Megan A, El-Sayed, Mostafa A

“…Nanoparticles as potential drug delivery vectors are drawing more attention every day. Here, we used gold nanopspheres (AuNSs) to selectively target the Wnt…”
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Comparative study of photothermolysis of cancer cells with nuclear-targeted or cytoplasm-targeted gold nanospheres: continuous wave or pulsed lasers by Huang, Xiaohua, Kang, Bin, Qian, Wei, Mackey, Megan A, Chen, Po C, Oyelere, Adegboyega K, El-Sayed, Ivan H, El-Sayed, Mostafa A

“…We conduct a comparative study on the efficiency and cell death pathways of continuous wave (cw) and nanosecond pulsed laser photothermal cancer therapy using…”
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