Search Results - "Mackenzie, Louise"

Use of Machine Learning and Artificial Intelligence to predict SARS-CoV-2 infection from Full Blood Counts in a population by Banerjee, Abhirup, Ray, Surajit, Vorselaars, Bart, Kitson, Joanne, Mamalakis, Michail, Weeks, Simonne, Baker, Mark, Mackenzie, Louise S.

“…•Early SARS-CoV-2 prediction from monocytes-leukocytes-eosinophils variable: AUC 84%.•Prediction in regular ward using machine learning from complete blood…”
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Thyroid Hormone Receptor Antagonists: From Environmental Pollution to Novel Small Molecules by Mackenzie, Louise S

“…Thyroid hormone receptors (TRs) are nuclear receptors which control transcription, and thereby have effects in all cells within the body. TRs are an important…”
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DenResCov-19: A deep transfer learning network for robust automatic classification of COVID-19, pneumonia, and tuberculosis from X-rays by Mamalakis, Michail, Swift, Andrew J., Vorselaars, Bart, Ray, Surajit, Weeks, Simonne, Ding, Weiping, Clayton, Richard H., Mackenzie, Louise S., Banerjee, Abhirup

“…The global pandemic of coronavirus disease 2019 (COVID-19) is continuing to have a significant effect on the well-being of the global population, thus…”
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Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies by Shamsaldeen, Yousif A, Mackenzie, Louise S, Lione, Lisa A, Benham, Christopher D

“…Diabetes mellitus (DM) is a pandemic metabolic disease characterized by a chronically elevated blood glucose concentration (hyperglycemia) due to insulin…”
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Harnessing the benefits of PPARβ/δ agonists by Mackenzie, Louise S., Lione, Lisa

“…Lipid mediators have complex effects on the cell; one of the key transcriptional factors that moderate proliferation and inflammatory effects is PPARβ/δ…”
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A robust COVID-19 mortality prediction calculator based on Lymphocyte count, Urea, C-Reactive Protein, Age and Sex (LUCAS) with chest X-rays by Ray, Surajit, Banerjee, Abhirup, Swift, Andrew, Fanstone, Joseph W., Mamalakis, Michail, Vorselaars, Bart, Wilkie, Craig, Cole, Joby, Mackenzie, Louise S., Weeks, Simonne

“…There have been numerous risk tools developed to enable triaging of SARS-CoV-2 positive patients with diverse levels of complexity. Here we presented a…”
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LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression by Kirkby, Nicholas S, Zaiss, Anne K, Urquhart, Paula, Jiao, Jing, Austin, Philip J, Al-Yamani, Malak, Lundberg, Martina H, MacKenzie, Louise S, Warner, Timothy D, Nicolaou, Anna, Herschman, Harvey R, Mitchell, Jane A

“…There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have…”
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Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery by Perez Diaz, Noelia, Lione, Lisa A, Hutter, Victoria, Mackenzie, Louise S

“…Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation…”
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Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists by Zloh, Mire, Perez-Diaz, Noelia, Tang, Leslie, Patel, Pryank, Mackenzie, Louise S.

“…Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. Use of in silico methods and pharmacology to investigate…”
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Discovery of novel small molecule inhibitors of S100P with in vitro anti-metastatic effects on pancreatic cancer cells by Camara, Ramatoulie, Ogbeni, Deborah, Gerstmann, Lisa, Ostovar, Mehrnoosh, Hurer, Ellie, Scott, Mark, Mahmoud, Nasir G., Radon, Tomasz, Crnogorac-Jurcevic, Tatjana, Patel, Pryank, Mackenzie, Louise S., Chau, David Y.S., Kirton, Stewart B., Rossiter, Sharon

“…S100P, a calcium-binding protein, is known to advance tumor progression and metastasis in pancreatic and several other cancers. Herein is described the in…”
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Development of a Mortality Prediction Model in Hospitalised SARS-CoV-2 Positive Patients Based on Routine Kidney Biomarkers by Boss, Anna N., Banerjee, Abhirup, Mamalakis, Michail, Ray, Surajit, Swift, Andrew J., Wilkie, Craig, Fanstone, Joseph W., Vorselaars, Bart, Cole, Joby, Weeks, Simonne, Mackenzie, Louise S.

“…Acute kidney injury (AKI) is a prevalent complication in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive inpatients, which is linked to…”
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In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone receptor antagonist properties by Perez Diaz, Noelia, Zloh, Mire, Patel, Pryank, Mackenzie, Louise S.

“…•In silico screening predicted that PGI2, beraprost, and GW0742 has the potential to bind to thyroid hormone β receptor (TRβ) and TRα.•Docking analysis…”
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Linking phospholipase C isoforms with differentiation function in human vascular smooth muscle cells by Mackenzie, Louise S., Lymn, Joanne S., Hughes, Alun D.

“…The phosphoinositol-phospholipase C (PLC) family of enzymes consists of a number of isoforms, each of which has different cellular functions. PLCγ1 is…”
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Role of prostacyclin in pulmonary hypertension by Mitchell, Jane A, Ahmetaj-Shala, Blerina, Kirkby, Nicholas S, Wright, William R, Mackenzie, Louise S, Reed, Daniel M, Mohamed, Nura

“…Prostacyclin is a powerful cardioprotective hormone released by the endothelium of all blood vessels. Prostacyclin exists in equilibrium with other vasoactive…”
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Staying in Touch: case study of artistic research during the COVID-19 lock-down by Mackenzie, Louise, Šebjanič, Robertina, Żyniewicz, Karolina, Burr Raty, Isabel, Honorato, Dalila

“…In April 2020, artists Robertina Šebjanič, Louise Mackenzie, Karolina Żyniewicz and Isabel Burr Raty were invited by Dalila Honorato to develop research on the…”
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Selective inhibition of NADPH oxidase reverses the over contraction of diabetic rat aorta by Rehman, Atif Ur, Dugic, Elma, Benham, Chris, Lione, Lisa, Mackenzie, Louise S

“…Abnormal vascular responsiveness in diabetes has been attributed to a number of changes in contractile pathways, affected in part by the overproduction of…”
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Aspirin‐triggered 15‐epi‐lipoxin A4 predicts cyclooxygenase‐2 in the lungs of LPS‐treated mice but not in the circulation: implications for a clinical test by Kirkby, Nicholas S., Chan, Melissa V., Lundberg, Martina H., Massey, Karen A., Edmands, William M. B., MacKenzie, Louise S., Holmes, Elaine, Nicolaou, Anna, Warner, Timothy D., Mitchell, Jane A.

“…Inhibition of cyclooxygenase (COX)‐2 increases cardiovascular deaths. Identifying a biomarker of COX‐2 is desirable but difficult, since COX‐1 and COX‐2…”
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Reply to Letter Regarding Article, “Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs” by Ahmetaj-Shala, Blerina, Kirkby, Nicholas S, Knowles, Rebecca, Al’Yamani, Malak, Mazi, Sara, Wang, Zhen, Tucker, Arthur T, Mackenzie, Louise S, Armstrong, Paul C.J, Nüsing, Rolf M, Tomlinson, James A P, Warner, Timothy D, Leiper, James, Mitchell, Jane A

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A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension by Mohamed, Nura A., Ahmetaj-Shala, Blerina, Duluc, Lucie, Mackenzie, Louise S., Kirkby, Nicholas S., Reed, Daniel M., Lickiss, Paul D., Davies, Robert P., Freeman, Gemma R., Wojciak-Stothard, Beata, Chester, Adrian H., El-Sherbiny, Ibrahim M., Mitchell, Jane A., Yacoub, Magdi H.

“…Pulmonary arterial hypertension (PAH) is a chronic and progressive disease which continues to carry an unacceptably high mortality and morbidity. The nitric…”
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Offering the Body: Performing proximity in the use of cellular material by Mackenzie, Louise

“…Cellular and sub-cellular material become creative medium across a range of disciplines that engage with biotechnology, from medicine to art practice…”
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