Search Results - "Mackenzie, Karen"

New prospects for targeting telomerase beyond the telomere by Arndt, Greg M., MacKenzie, Karen L.

“…Key Points Telomerase is a ribonucleoprotein complex responsible for maintaining chromosome-end structures called telomeres. Telomerase activity enables…”
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cGAS surveillance of micronuclei links genome instability to innate immunity by Mackenzie, Karen J., Carroll, Paula, Martin, Carol-Anne, Murina, Olga, Fluteau, Adeline, Simpson, Daniel J., Olova, Nelly, Sutcliffe, Hannah, Rainger, Jacqueline K., Leitch, Andrea, Osborn, Ruby T., Wheeler, Ann P., Nowotny, Marcin, Gilbert, Nick, Chandra, Tamir, Reijns, Martin A. M., Jackson, Andrew P.

“…The cytoplasmic DNA sensor cGAS detects DNA in ruptured micronuclei and activates an innate immune response. Autoimmunity under surveillance Innate immune…”
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Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response by Mackenzie, Karen J, Carroll, Paula, Lettice, Laura, Tarnauskaitė, Žygimantė, Reddy, Kaalak, Dix, Flora, Revuelta, Ailsa, Abbondati, Erika, Rigby, Rachel E, Rabe, Björn, Kilanowski, Fiona, Grimes, Graeme, Fluteau, Adeline, Devenney, Paul S, Hill, Robert E, Reijns, Martin AM, Jackson, Andrew P

“…Aicardi–Goutières syndrome (AGS) provides a monogenic model of nucleic acid‐mediated inflammation relevant to the pathogenesis of systemic autoimmunity…”
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SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability by Marshall, Glenn M, Liu, Pei Y, Gherardi, Samuele, Scarlett, Christopher J, Bedalov, Antonio, Xu, Ning, Iraci, Nuncio, Valli, Emanuele, Ling, Dora, Thomas, Wayne, van Bekkum, Margo, Sekyere, Eric, Jankowski, Kacper, Trahair, Toby, Mackenzie, Karen L, Haber, Michelle, Norris, Murray D, Biankin, Andrew V, Perini, Giovanni, Liu, Tao

“…The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low-level to a high-level N-Myc…”
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Pan-cancer proteomic map of 949 human cell lines by Gonçalves, Emanuel, Poulos, Rebecca C., Cai, Zhaoxiang, Barthorpe, Syd, Manda, Srikanth S., Lucas, Natasha, Beck, Alexandra, Bucio-Noble, Daniel, Dausmann, Michael, Hall, Caitlin, Hecker, Michael, Koh, Jennifer, Lightfoot, Howard, Mahboob, Sadia, Mali, Iman, Morris, James, Richardson, Laura, Seneviratne, Akila J., Shepherd, Rebecca, Sykes, Erin, Thomas, Frances, Valentini, Sara, Williams, Steven G., Wu, Yangxiu, Xavier, Dylan, MacKenzie, Karen L., Hains, Peter G., Tully, Brett, Robinson, Phillip J., Zhong, Qing, Garnett, Mathew J., Reddel, Roger R.

“…The proteome provides unique insights into disease biology beyond the genome and transcriptome. A lack of large proteomic datasets has restricted the…”
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Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota by McFarlane, Amanda J., PhD, McSorley, Henry J., PhD, Davidson, Donald J., MBChB, PhD, Fitch, Paul M., PhD, Errington, Claire, BSc, Mackenzie, Karen J., MBChB, PhD, Gollwitzer, Eva S., PhD, Johnston, Chris J.C., MRCP, PhD, MacDonald, Andrew S., PhD, Edwards, Michael R., PhD, Harris, Nicola L., PhD, Marsland, Benjamin J., PhD, Maizels, Rick M., PhD, Schwarze, Jürgen, MD

“…Background Helminth parasites have been reported to have beneficial immunomodulatory effects in patients with allergic and autoimmune conditions and…”
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Cathelicidin host defence peptide augments clearance of pulmonary Pseudomonas aeruginosa infection by its influence on neutrophil function in vivo by Beaumont, Paula E, McHugh, Brian, Gwyer Findlay, Emily, Mackellar, Annie, Mackenzie, Karen J, Gallo, Richard L, Govan, John R W, Simpson, A John, Davidson, Donald J

“…Cathelicidins are multifunctional cationic host-defence peptides (CHDP; also known as antimicrobial peptides) and an important component of innate host defence…”
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Effect of 6 Months of Flash Glucose Monitoring in Youth With Type 1 Diabetes and High-Risk Glycemic Control: A Randomized Controlled Trial by Boucher, Sara E, Gray, Andrew R, Wiltshire, Esko J, de Bock, Martin I, Galland, Barbara C, Tomlinson, Paul A, Rayns, Jenny A, MacKenzie, Karen E, Chan, Huan, Rose, Shelley, Wheeler, Benjamin J

“…To investigate whether intermittently scanned continuous glucose monitoring (isCGM) significantly improves glycemic control compared with capillary…”
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Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis by Martin, Carol-Anne, Murray, Jennie E, Carroll, Paula, Leitch, Andrea, Mackenzie, Karen J, Halachev, Mihail, Fetit, Ahmed E, Keith, Charlotte, Bicknell, Louise S, Fluteau, Adeline, Gautier, Philippe, Hall, Emma A, Joss, Shelagh, Soares, Gabriela, Silva, João, Bober, Michael B, Duker, Angela, Wise, Carol A, Quigley, Alan J, Phadke, Shubha R, Wood, Andrew J, Vagnarelli, Paola, Jackson, Andrew P

“…Compaction of chromosomes is essential for accurate segregation of the genome during mitosis. In vertebrates, two condensin complexes ensure timely chromosome…”
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Differentially expressed genes from RNA-Seq and functional enrichment results are affected by the choice of single-end versus paired-end reads and stranded versus non-stranded protocols by Corley, Susan M, MacKenzie, Karen L, Beverdam, Annemiek, Roddam, Louise F, Wilkins, Marc R

“…RNA-Seq is now widely used as a research tool. Choices must be made whether to use paired-end (PE) or single-end (SE) sequencing, and whether to use…”
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CD30 and ALK combination therapy has high therapeutic potency in RANBP2-ALK-rearranged epithelioid inflammatory myofibroblastic sarcoma by Fordham, Ashleigh M., Xie, Jinhan, Gifford, Andrew J., Wadham, Carol, Morgan, Lisa T., Mould, Emily V. A., Fadia, Mitali, Zhai, Lei, Massudi, Hassina, Ali, Zara S., Marshall, Glenn M., Lukeis, Robyn E., Fletcher, Jamie I., MacKenzie, Karen L., Trahair, Toby N.

“…Background Epithelioid inflammatory myofibroblastic sarcoma (eIMS) is characterised by perinuclear ALK localisation, CD30 expression and early relapse despite…”
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End Products of Telomere Research by Reddel, Roger R., MacKenzie, Karen L., Bryan, Tracy M.

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RNA:DNA hybrids are a novel molecular pattern sensed by TLR9 by Rigby, Rachel E, Webb, Lauren M, Mackenzie, Karen J, Li, Yue, Leitch, Andrea, Reijns, Martin A M, Lundie, Rachel J, Revuelta, Ailsa, Davidson, Donald J, Diebold, Sandra, Modis, Yorgo, MacDonald, Andrew S, Jackson, Andrew P

“…The sensing of nucleic acids by receptors of the innate immune system is a key component of antimicrobial immunity. RNA:DNA hybrids, as essential intracellular…”
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WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma by Sun, Yuting, Bell, Jessica L, Carter, Daniel, Gherardi, Samuele, Poulos, Rebecca C, Milazzo, Giorgio, Wong, Jason W H, Al-Awar, Rima, Tee, Andrew E, Liu, Pei Y, Liu, Bing, Atmadibrata, Bernard, Wong, Matthew, Trahair, Toby, Zhao, Quan, Shohet, Jason M, Haupt, Ygal, Schulte, Johannes H, Brown, Peter J, Arrowsmith, Cheryl H, Vedadi, Masoud, MacKenzie, Karen L, Hüttelmaier, Stefan, Perini, Giovanni, Marshall, Glenn M, Braithwaite, Antony, Liu, Tao

“…MYCN gene amplification in neuroblastoma drives a gene expression program that correlates strongly with aggressive disease. Mechanistically, trimethylation of…”
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DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts by Richards, Laura A, Kumari, Ashu, Knezevic, Kathy, Thoms, Julie Ai, von Jonquieres, Georg, Napier, Christine E, Ali, Zara, O'Brien, Rosemary, Marks-Bluth, Jonathon, Maritz, Michelle F, Pickett, Hilda A, Morris, Jonathan, Pimanda, John E, MacKenzie, Karen L

“…Telomerase is a ribonucleoprotein complex that maintains the length and integrity of telomeres, and thereby enables cellular proliferation. Understanding the…”
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Use of intermittently scanned continuous glucose monitoring in young people with high‐risk type 1 diabetes—Extension phase outcomes following a 6‐month randomized control trial by Rose, Shelley, Styles, Sara E., Wiltshire, Esko J., Stanley, James, Galland, Barbara C., Bock, Martin I., Tomlinson, Paul A., Rayns, Jenny A., MacKenzie, Karen E., Wheeler, Benjamin J.

“…Aims To describe the impact of a 12‐month intervention using intermittently scanned continuous glucose monitoring (isCGM) on glycaemic control and glucose test…”
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Therapeutic targeting of replicative immortality by Yaswen, Paul, MacKenzie, Karen L, Keith, W. Nicol, Hentosh, Patricia, Rodier, Francis, Zhu, Jiyue, Firestone, Gary L, Matheu, Ander, Carnero, Amancio, Bilsland, Alan, Sundin, Tabetha, Honoki, Kanya, Fujii, Hiromasa, Georgakilas, Alexandros G, Amedei, Amedeo, Amin, Amr, Helferich, Bill, Boosani, Chandra S, Guha, Gunjan, Ciriolo, Maria Rosa, Chen, Sophie, Mohammed, Sulma I, Azmi, Asfar S, Bhakta, Dipita, Halicka, Dorota, Niccolai, Elena, Aquilano, Katia, Ashraf, S. Salman, Nowsheen, Somaira, Yang, Xujuan

“…Abstract One of the hallmarks of malignant cell populations is the ability to undergo continuous proliferation. This property allows clonal lineages to acquire…”
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MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin by O'Brien, Rosemary, Tran, Sieu L, Maritz, Michelle F, Liu, Bing, Kong, Cheng Fei, Purgato, Stefania, Yang, Chen, Murray, Jayne, Russell, Amanda J, Flemming, Claudia L, von Jonquieres, Georg, Pickett, Hilda A, London, Wendy B, Haber, Michelle, Gunaratne, Preethi H, Norris, Murray D, Perini, Giovanni, Fletcher, Jamie I, MacKenzie, Karen L

“…The RNA-binding protein dyskerin, encoded by the DKC1 gene, functions as a core component of the telomerase holoenzyme as well as ribonuclear protein complexes…”
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Retrospective analysis of clinical characteristics and outcomes of patients with carcinoma of unknown primary from three tertiary centers in Australia by Boys, Emma L., Gao, Bo, Grimison, Peter, Sutherland, Sarah, MacKenzie, Karen L., Reddel, Roger R., Liu, Jia

“…Background Carcinoma of unknown primary (CUP) remains an important tumor entity and a disproportionate cause of cancer mortality. Little is known about the…”
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Targeted Therapy of TERT -Rearranged Neuroblastoma with BET Bromodomain Inhibitor and Proteasome Inhibitor Combination Therapy by Chen, Jingwei, Nelson, Christopher, Wong, Matthew, Tee, Andrew E, Liu, Pei Y, La, Ting, Fletcher, Jamie I, Kamili, Alvin, Mayoh, Chelsea, Bartenhagen, Christoph, Trahair, Toby N, Xu, Ning, Jayatilleke, Nisitha, Wong, Marie, Peng, Hui, Atmadibrata, Bernard, Cheung, Belamy B, Lan, Qing, Bryan, Tracy M, Mestdagh, Pieter, Vandesompele, Jo, Combaret, Valerie, Boeva, Valentina, Wang, Jenny Y, Janoueix-Lerosey, Isabelle, Cowley, Mark J, MacKenzie, Karen L, Dolnikov, Alla, Li, Jinyan, Polly, Patsie, Marshall, Glenn M, Reddel, Roger R, Norris, Murray D, Haber, Michelle, Fischer, Matthias, Zhang, Xu D, Pickett, Hilda A, Liu, Tao

“…gene rearrangement with transcriptional superenhancers leads to overexpression and neuroblastoma. No targeted therapy is available for clinical trials in…”
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