Search Results - "Mackenzie, Gerardo"

Curcumin formulated in solid lipid nanoparticles has enhanced efficacy in Hodgkin's lymphoma in mice by Guorgui, Jacob, Wang, Ruixue, Mattheolabakis, George, Mackenzie, Gerardo G.

“…Curcumin reduces Hodgkin's lymphoma (HL) cell growth in vitro, but its unfavorable pharmacokinetics highlight the need for novel in vivo delivery systems…”
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Chlorogenic acid combined with epigallocatechin-3-gallate mitigates D-galactose-induced gut aging in mice by Wei, Ran, Su, Zhucheng, Mackenzie, Gerardo G

“…Chlorogenic acid (CGA) and epigallocatechin-3-gallate (EGCG) are major polyphenolic constituents of coffee and green tea with beneficial health properties. In…”
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A high-fat diet induces changes in mesenteric adipose tissue accelerating early-stage pancreatic carcinogenesis in mice by Ead, Aya S., Wirkus, Joanna, Matsukuma, Karen, Mackenzie, Gerardo G.

“…•A high-fat diet accelerates pancreatic carcinogenesis by activating ERK and STAT3.•A high-fat diet promotes immune cell infiltration in the pancreas.•A…”
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EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines by Wei, Ran, Wirkus, Joanna, Yang, Zixuan, Machuca, Jazmin, Esparza, Yasmin, Mackenzie, Gerardo G.

“…Epigallocatechin-3-gallate (EGCG), a major polyphenol component of green tea, presents anticancer efficacy. However, its exact mechanism of action is not…”
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Ketogenic Diets in Pancreatic Cancer and Associated Cachexia: Cellular Mechanisms and Clinical Perspectives by Cortez, Natalia E., Mackenzie, Gerardo G.

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and extremely therapy-resistant cancer. It is estimated that up to 80% of PDAC patients present with…”
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Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models by Wei, Ran, Mao, Limin, Xu, Ping, Zheng, Xinghai, Hackman, Robert M, Mackenzie, Gerardo G, Wang, Yuefei

“…Numerous studies propose that epigallocatechin-3-gallate (EGCG), an abundant polyphenol in green tea, has anti-cancer properties. However, its mechanism of…”
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The inhibitory effect of ECG and EGCG dimeric procyanidins on colorectal cancer cells growth is associated with their actions at lipid rafts and the inhibition of the epidermal growth factor receptor signaling by Zhu, Wei, Li, Mei C., Wang, Feng R., Mackenzie, Gerardo G., Oteiza, Patricia I.

“…[Display omitted] Colorectal cancer (CRC) is one of the most common cancers worldwide. Epidemiological studies indicate that consumption of fruits and…”
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Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts by Wei, Ran, Hackman, Robert M., Wang, Yuefei, Mackenzie, Gerardo G.

“…Pancreatic cancer is a complex disease, in need of new therapeutic approaches. In this study, we explored the effect and mechanism of action of…”
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Pancreatic cancer: A critical review of dietary risk by Salem, Asmaa A., Mackenzie, Gerardo G.

“…Pancreatic cancer is a deadly disease. It is estimated that about 90% of pancreatic cancer cases are due to environmental risk factors. Among these,…”
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Combination of miR‑143 and miR‑506 reduces lung and pancreatic cancer cell growth through the downregulation of cyclin‑dependent kinases by Hossian, A K M Nawshad, Mackenzie, Gerardo G, Mattheolabakis, George

“…Lung cancer (LC) and pancreatic cancer (PC) are the first and fourth leading causes of cancer‑related deaths in the US. Deregulated cell cycle progression is…”
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Phospho-Aspirin (MDC-22) inhibits pancreatic cancer growth in patient-derived tumor xenografts and KPC mice by targeting EGFR: Enhanced efficacy in combination with irinotecan by Rodriguez Lanzi, Cecilia, Wei, Ran, Luo, Dingyuan, Mackenzie, Gerardo G.

“…Novel therapeutic strategies are needed in the fight against pancreatic cancer. We have previously documented the chemopreventive effect of MDC-22 in…”
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(-)-Epigallocatechin-3-gallate mitigates cyclophosphamide-induced intestinal injury by modulating the tight junctions, inflammation and dysbiosis in mice by Wei, Ran, Liu, Xingquan, Wang, Yuefei, Dong, Junjie, Wu, Fenghua, Mackenzie, Gerardo G, Su, Zhucheng

“…Cyclophosphamide (CTX) is an antitumor drug commonly used to treat various cancer types. Unfortunately, its toxic side effects, including gastrointestinal (GI)…”
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Impact of dietary fat composition and quantity in pancreatic carcinogenesis: Recent advances and controversies by Wirkus, Joanna, Ead, Aya S., Mackenzie, Gerardo G.

“…A significant number of pancreatic cancer cases are due to modifiable risk factors, with many being attributed to increased body fatness. This has sparked…”
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Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice by Mackenzie, Gerardo G, Huang, Liqun, Alston, Ninche, Ouyang, Nengtai, Vrankova, Kvetoslava, Mattheolabakis, George, Constantinides, Panayiotis P, Rigas, Basil

“…New agents are needed to treat pancreatic cancer, one of the most lethal human malignancies. We synthesized phospho-valproic acid, a novel valproic acid…”
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[Corrigendum] Phospho‑valproic acid inhibits pancreatic cancer growth in mice: Enhanced efficacy by its formulation in poly‑(L)‑lactic acid‑poly(ethylene glycol) nanoparticles by Mattheolabakis, George, Wang, Ruixue, Rigas, Basil, Mackenzie, Gerardo

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Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine by Wei, Ran, Penso, Natalia E Cortez, Hackman, Robert M, Wang, Yuefei, Mackenzie, Gerardo G

“…Most pancreatic cancers are usually diagnosed at an advanced stage when they have already metastasized. Epigallocatechin-3-gallate (EGCG), a major polyphenolic…”
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DHA-SBT-1214 Taxoid Nanoemulsion and Anti-PD-L1 Antibody Combination Therapy Enhances Antitumor Efficacy in a Syngeneic Pancreatic Adenocarcinoma Model by Ahmad, Gulzar, Mackenzie, Gerardo G, Egan, James, Amiji, Mansoor M

“…The goal of this study was to evaluate combination of a novel taxoid, DHA-SBT-1214 chemotherapy, in modulating immune checkpoint marker expression and…”
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Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine by Cortez, Natalia E, Lanzi, Cecilia Rodriguez, Vahmani, Payam, Matsukuma, Karen, Mackenzie, Gerardo G

“…Ketogenic diets (KDs) are actively being evaluated for their potential anticancer effects. Although KDs are generally considered safe, their safety profile…”
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Hyaluronic acid nanoparticle-encapsulated microRNA-125b repolarizes tumor-associated macrophages in pancreatic cancer by Parayath, Neha N, Hong, Brian V, Mackenzie, Gerardo G, Amiji, Mansoor M

“…To investigate a novel strategy to target tumor-associated macrophages and reprogram them to an antitumor phenotype in pancreatic adenocarcinoma (PDAC). M2…”
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A Ketogenic Diet in Combination with Gemcitabine Mitigates Pancreatic Cancer-Associated Cachexia in Male and Female KPC Mice by Cortez, Natalia E, Pathak, Suraj, Rodriguez Lanzi, Cecilia, Hong, Brian V, Crone, Ryman, Sule, Rasheed, Wang, Fangyi, Chen, Shuai, Gomes, Aldrin V, Baar, Keith, Mackenzie, Gerardo G

“…Cancer-associated cachexia (CAC) is a critical contributor to pancreatic ductal adenocarcinoma (PDAC) mortality. Thus, there is an urgent need for new…”
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