Search Results - "Mackensen, Daniel"

Biodistribution of monoclonal antibodies : scale-up from mouse to human using a physiologically based pharmacokinetic model by BAXTER, L. T, HUI ZHU, MACKENSEN, D. G, BUTLER, W. F, JAIN, R. K

“…The efficacy of a novel diagnostic or therapeutic agent depends on its selective localization in a target tissue. Biodistribution studies are expensive and…”
Get full text

Reversal of Vinca alkaloid resistance by anti-P-glycoprotein monoclonal antibody HYB-241 in a human tumor xenograft by RITTMANN-GRAUER, L. S, YONG, M. A, SANDERS, V, MACKENSEN, D. G

“…A panel of monoclonal antibodies (MAbs) to P-glycoprotein was developed by immunization of mice with multidrug-resistant human neuroepithelioma and…”
Get full text

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice by BAXTER, L. T, HUI ZHU, MACKENSEN, D. G, JAIN, R. K

“…A physiologically based pharmacokinetic model to describe the biodistribution of a specific monoclonal antibody IgG1 (ZCE025) and its fragments (F(ab')2 and…”
Get full text

Association of Intestinal Peptide Transport with a Protein Related to the Cadherin Superfamily by Dantzig, Anne H., Hoskins, JoAnn, Tabas, Linda B., Bright, Stuart, Shepard, Robert L., Jenkins, Ivan L., Duckworth, Dale C., Sportsman, J. Richard, Mackensen, Daniel, Rosteck, Paul R., Skatrud, Paul L.

“…The first step in oral absorption of many medically important peptide-based drugs is mediated by an intestinal proton-dependent peptide transporter. This…”
Get full text

Site-specific prodrug activation by antibody-β-lactamase conjugates : regression and long-term growth inhibition of human colon carcinoma xenograft models by MEYER, D. L, JUNGHEIM, L. N, LAW, K. L, MIKOLAJCZYK, S. D, SHEPHERD, T. A, MARCKENSEN, S. G, BRIGGS, S. L, STARLING, J. J

“…Antibody-directed catalysis (ADC) is a two-step method for the delivery of chemotherapeutic agents in which enzyme-antibody conjugate, prelocalized to…”
Get full text

Effect of pre-irradiation on radiopharmaceutical localization in human colon tumor xenografts using mono- and bispecific monoclonal antibodies by Gridley, D S, Slater, J B, Mackensen, D G, Slater, J M

“…In previous investigations we found that pre-irradiation of a tumor can significantly increase site-specific accumulation of radiolabeled monoclonal antibodies…”
Get more information

Effects of proton irradiation on radiolabeled monoclonal antibody uptake in human colon tumor xenografts by Gridley, D S, Mackensen, D G, Slater, J B, Moyers, M F, Slater, J M

“…A major limitation of radiolabeled monoclonal antibodies (MAbs) for cancer imaging and therapy is their low accumulation within solid tumors. We, and others,…”
Get more information

Prediction of tumor response to experimental radioimmunotherapy with 90Y in nude mice by Dillehay, L E, Mayer, R, Zhang, Y G, Shao, Y, Song, S Y, Mackensen, D G, Williams, J R

“…To identify those factors that predict variability in tumor response to 90Y-radioimmunotherapy based on measurement of incorporated activity and physical…”
Get more information

Use of bremsstrahlung radiation to monitor Y-90 tumor and whole body activities during experimental radioimmunotherapy in mice by Dillehay, L E, Mayer, R, Zhang, Y G, Song, S Y, Shao, Y, Mackensen, D G, Williams, J R

“…Large differences in uptake between tumors, even for the same size, frequently observed in clinical and experimental radioimmunotherapy (RAIT), make monitoring…”
Get more information

Radiolocalization of human small cell lung cancer and antigen-positive normal tissues using monoclonal antibody LS2D617 by WILSON, B. S, PETRELLA, E, LOWE, S. R, LIEN, K, MACKENSEN, D. G, GRIDLEY, D. S, STICKNEY, D. R

“…The murine monoclonal antibody LS2D617, which reacts with an antigen associated with human small cell lung carcinoma (SCLC), was tested in preclinical models…”
Get full text