Search Results - "Mackem, Susan"

A Near-IR Uncaging Strategy Based on Cyanine Photochemistry by Gorka, Alexander P, Nani, Roger R, Zhu, Jianjian, Mackem, Susan, Schnermann, Martin J

“…The development of photocaging groups activated by near-IR light would enable new approaches for basic research and allow for spatial and temporal control of…”
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Rethinking positional information and digit identity: The role of late interdigit signaling by Huang, Bau‐Lin, Mackem, Susan

“…Seminal work from John Fallon's lab has illuminated how digit identity determination involves ongoing late regulation and occurs progressively during phalanx…”
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Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT by Zhu, Jianjian, Kwan, Kin Ming, Mackem, Susan

“…The transcription factor Brachyury (T) gene is expressed throughout primary mesoderm (primitive streak and notochord) during early embryonic development and…”
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An integrative approach to understanding bird origins by Xu, Xing, Zhou, Zhonghe, Dudley, Robert, Mackem, Susan, Chuong, Cheng-Ming, Erickson, Gregory M., Varricchio, David J.

“…Recent discoveries of spectacular dinosaur fossils overwhelmingly support the hypothesis that birds are descended from maniraptoran theropod dinosaurs, and…”
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Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud by Zhu, Jianjian, Nakamura, Eiichiro, Nguyen, Minh-Thanh, Bao, Xiaozhong, Akiyama, Haruhiko, Mackem, Susan

“…Sonic hedgehog (Shh), which regulates proliferation in many contexts, functions as a limb morphogen to specify a distinct pattern of digits. How Shh's effects…”
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Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy by Mak, Kinglun Kingston, Kronenberg, Henry M, Chuang, Pao-Tien, Mackem, Susan, Yang, Yingzi

“…Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte hypertrophy is also required in…”
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mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses by Matsumoto, Kazu, Irie, Fumitoshi, Mackem, Susan, Yamaguchi, Yu

“…Multiple hereditary exostoses (MHE) is one of the most common skeletal dysplasias, exhibiting the formation of multiple cartilage-capped bony protrusions…”
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Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration by Sahu, Sounak, Albaugh, Mary E., Martin, Betty K., Patel, Nimit L., Riffle, Lisa, Mackem, Susan, Kalen, Joseph D., Sharan, Shyam K.

“…Signaling pathways play an important role in cell fate determination in stem cells and regulate a plethora of developmental programs, the dysregulation of…”
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A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2 by Losa, Marta, Barozzi, Iros, Osterwalder, Marco, Hermosilla-Aguayo, Viviana, Morabito, Angela, Chacón, Brandon H., Zarrineh, Peyman, Girdziusaite, Ausra, Benazet, Jean Denis, Zhu, Jianjian, Mackem, Susan, Capellini, Terence D., Dickel, Diane, Bobola, Nicoletta, Zuniga, Aimée, Visel, Axel, Zeller, Rolf, Selleri, Licia

“…A lingering question in developmental biology has centered on how transcription factors with widespread distribution in vertebrate embryos can perform…”
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An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism by Huang, Bau-Lin, Trofka, Anna, Furusawa, Aki, Norrie, Jacqueline L., Rabinowitz, Adam H., Vokes, Steven A., Mark Taketo, M., Zakany, Jozsef, Mackem, Susan

“…The number of phalanges and joints are key features of digit ‘identity’ and are central to limb functionality and evolutionary adaptation. Prior chick work…”
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Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life by Hirai, Takao, Chagin, Andrei S, Kobayashi, Tatsuya, Mackem, Susan, Kronenberg, Henry M

“…Parathyroid hormone (PTH)-related protein (PTHrP), regulated by Indian hedgehog and acting through the PTH/PTHrP receptor (PPR), is crucial for normal…”
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Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates by Trofka, Anna, Huang, Bau-Lin, Zhu, Jianjian, Heinz, William F., Magidson, Valentin, Shibata, Yuki, Shi, Yun-Bo, Tarchini, Basile, Stadler, H. Scott, Kabangu, Mirindi, Al Haj Baddar, Nour W., Voss, S. Randal, Mackem, Susan

“…In most tetrapod vertebrates, limb skeletal progenitors condense with postaxial dominance. Posterior elements (such as ulna and fibula) appear prior to their…”
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Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone by Maeda, Yukiko, Nakamura, Eiichiro, Nguyen, Minh-Thanh, Suva, Larry J, Swain, Frances L, Razzaque, Mohammed S, Mackem, Susan, Lanske, Beate

“…Indian hedgehog (Ihh) is essential for chondrocyte and osteoblast proliferation/differentiation during prenatal endochondral bone formation. The early…”
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Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development by Galli, Antonella, Robay, Dimitri, Osterwalder, Marco, Bao, Xiaozhong, Bénazet, Jean-Denis, Tariq, Muhammad, Paro, Renato, Mackem, Susan, Zeller, Rolf

“…The polarization of nascent embryonic fields and the endowment of cells with organizer properties are key to initiation of vertebrate organogenesis. One such…”
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Tamoxifen-dependent, inducible Bmp2CreER drives selective recombinase activity in early interdigital mesenchyme and digit collateral ligaments by Huang, Bau-Lin, Mackem, Susan

“…During limb development, the interdigital mesenchyme has been proposed to play a signaling role instructing morphogenesis of different digit types, as well as…”
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Limb anterior–posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3 by Bowers, Megan, Eng, Liane, Lao, Zhimin, Turnbull, Rowena K., Bao, Xiaozhong, Riedel, Elyn, Mackem, Susan, Joyner, Alexandra L.

“…Anterior–posterior (AP) limb patterning is directed by sonic hedgehog (SHH) signaling from the posteriorly located zone of polarizing activity (ZPA). GLI3 and…”
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Non-canonical Wnt5a/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension by Yun, Kangsun, Ajima, Rieko, Sharma, Nirmala, Costantini, Frank, Mackem, Susan, Lewandoski, Mark, Yamaguchi, Terry P, Perantoni, Alan O

“…Congenital anomalies of the kidney and urinary tract (CAKUT) affect about 1 in 500 births and are a major cause of morbidity in infants. Duplex collecting…”
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PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud by Norrie, Jacqueline L, Li, Qiang, Co, Swanie, Huang, Bau-Lin, Ding, Ding, Uy, Jann C, Ji, Zhicheng, Mackem, Susan, Bedford, Mark T, Galli, Antonella, Ji, Hongkai, Vokes, Steven A

“…During embryonic development, undifferentiated progenitor cells balance the generation of additional progenitor cells with differentiation. Within the…”
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Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal by Sebastian, Arjun, Matsushita, Takehiko, Kawanami, Aya, Mackem, Susan, Landreth, Gary E., Murakami, Shunichi

“…Activating mutations in FGFR3 cause the most common forms of human dwarfism: achondroplasia and thanatophoric dysplasia. In mouse models of achondroplasia,…”
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The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells by Gegonne, Anne, Tai, Xuguang, Zhang, Jinghui, Wu, Gang, Zhu, Jianjian, Yoshimoto, Aki, Hanson, Jeffrey, Cultraro, Constance, Chen, Qing-Rong, Guinter, Terry, Yang, Zhihui, Hathcock, Karen, Singer, Alfred, Rodriguez-Canales, Jaime, Tessarollo, Lino, Mackem, Susan, Meerzaman, Daoud, Buetow, Ken, Singer, Dinah S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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