Search Results - "Mackem, S"

Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo by Hermesz, E, Mackem, S, Mahon, K A

“…We have isolated a new murine homeobox gene, Rpx (for Rathke's pouch homeobox), that is dynamically expressed in the prospective cephalic region of the embryo…”
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Two novel chick T-box genes related to mouse Brachyury are expressed in different, non-overlapping mesodermal domains during gastrulation by Knezevic, V, De Santo, R, Mackem, S

“…The mouse Brachyury (T) gene plays critical roles in the genesis of normal mesoderm during gastrulation and in the maintenance of a functioning notochord…”
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Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop by Knezevic, V, De Santo, R, Schughart, K, Huffstadt, U, Chiang, C, Mahon, K A, Mackem, S

“…Several 5′ members of the Hoxd cluster are expressed in nested posterior-distal domains of the limb bud suggesting a role in regulating anteroposterior…”
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Continuing organizer function during chick tail development by Knezevic, V, De Santo, R, Mackem, S

“…Development of the posterior body (lumbosacral region and tail) in vertebrates is delayed relative to gastrulation. In amniotes, it proceeds with the…”
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Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes by Mackem, S, Roizman, B

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Differentiation between α Promoter and Regulator Regions of Herpes Simplex Virus 1: The Functional Domains and Sequence of a Movable α Regulator by Mackem, Susan, Roizman, Bernard

“…The herpes simplex virus genome consists of at least three groups of genes--α,β , and γ --whose expression is coordinately regulated and sequentially ordered…”
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Ghox 4.7: a chick homeobox gene expressed primarily in limb buds with limb-type differences in expression by Mackem, S, Mahon, K A

“…Homeobox genes play a key role in specifying the segmented body plan of Drosophila, and recent work suggests that at least several homeobox genes may play a…”
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Regulation of Herpesvirus Macromolecular Synthesis: Transcription-Initiation Sites and Domains of α Genes by Mackem, Susan, Roizman, Bernard

“…Herpes simplex virus 1 (HSV-1) specifies in the infected cell a set of polypeptides (α ) whose mRNAs are made in the absence of protein synthesis. The…”
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Ovarian carcinoma as a cause of Zollinger-Ellison syndrome. Natural history, secretory products, and response to provocative tests by Maton, P N, Mackem, S M, Norton, J A, Gardner, J D, O'Dorisio, T M, Jensen, R T

“…Zollinger-Ellison syndrome is usually caused by a gastrin-secreting tumor in or near the pancreas. We describe a patient in whom an ovarian cystadenocarcinoma…”
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Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning by Celli, Giulia, LaRochelle, William J., Mackem, Susan, Sharp, Richard, Merlino, Glenn

“…Despite a wealth of experimental data implicating fibroblast growth factor (FGF) signaling in various developmental processes, genetic inactivation of…”
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Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh by Chen, Yuting, Knezevic, Vladimir, Ervin, Valerie, Hutson, Richard, Ward, Yvona, Mackem, Susan

“…Sonic hedgehog (Shh) signaling regulates both digit number and identity, but how different distinct digit types (identities) are specified remains unclear. Shh…”
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Regulation of α Genes of Herpes Simplex Virus: The α 27 Gene Promoter-Thymidine Kinase Chimera Is Positively Regulated in Converted L Cells by Mackem, S, Roizman, B

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Regulation of herpesvirus macromolecular synthesis: temporal order of transcription of alpha genes is not dependent on the stringency of inhibition of protein synthesis by Mackem, S, Roizman, B

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Down-Regulation of Nucleosomal Binding Protein HMGN1 Expression during Embryogenesis Modulates Sox9 Expression in Chondrocytes by Furusawa, Takashi, Lim, Jae-Hwan, Catez, Frédéric, Birger, Yehudit, Mackem, Susan, Bustin, Michael

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IGF-1R Signaling in Chondrocytes Modulates Growth Plate Development by Interacting With the PTHrP/lhh Pathway by Wang, Y, Cheng, Z, Elalieh, H Z, Nakamura, E, Nguyen, M-T, Mackem, S, Clemens, T L, Bikle, D D, Chang, W

“…Systemic derangements and perinatal death of generalized insulin-like growth factor 1 (IGF-1)and IGF-1 receptor (IGF-1R) knockout mice preclude definitive…”
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Transient Activation of Wnt/b-Catenin Signaling Induces Abnormal Growth Plate Closure and Articular Cartilage Thickening in Postnatal Mice by Yuasa, T, Kondo, N, Yasuhara, R, Shimono, K, Mackem, S, Pacifici, M, Iwamoto, M, Enomoto-Iwamoto, M

“…Wnt/b-catenin signaling is required for skeletal development and organization and for function of the growth plate and articular cartilage. To further clarify…”
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Limb-type differences in expression domains of certain chick Hox-4 genes and relationship to pattern modification for flight by Mackem, S, Ranson, M, Mahon, K

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Do 5'Hoxd genes play a role in initiating or maintaining A-P polarizing signals in the limb? by Mackem, S, Knezevic, V

“…The analysis of multiple null mutants generated through targeted disruption indicates that the 5' members of the Hoxd and Hoxa clusters determine the skeletal…”
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Down-regulation of nucleosomal inding protein HMGN1 expression during embrogenesis modulates Sox9 expression in chondrocytes by Furusawa, T., J. H., Lim, Catez, F., Birger, Y., Mackem, S., Bustin, M.

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Ventral tail bud mesenchyme is a signaling center for tail paraxial mesoderm induction by Liu, Chunqiao, Knezevic, Vladimir, Mackem, Susan

“…A large body of evidence from several systems indicates that formation of the vertebrate tail is morphogenetically continuous with gastrulation, including…”
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