Search Results - "Mackay, IR"

Primary biliary cirrhosis: paradigm or paradox for autoimmunity by Gershwin, M E, Mackay, I R

“…Primary biliary cirrhosis has been classified as a model autoimmune disease based on striking defects in immune regulation and the presence of autoantibodies…”
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Autoimmunity and primary biliary cirrhosis by Mackay, Ian R.

“…The history of primary biliary cirrhosis (PBC) began in 1851, with autoimmunity introduced in 1958 and expanded from the 1960s on. In PBC, autoantibodies are…”
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Clustering and commonalities among autoimmune diseases by Mackay, Ian R

“…Abstract The concept that autoimmune diseases are characterized by shared (common) threads is well illustrated by their propensity to co-associate in a patient…”
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Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group by Vergani, Diego, Alvarez, Fernando, Bianchi, Francesco B., Cançado, Eduardo L.R., Mackay, Ian R., Manns, Michael P., Nishioka, Mikio, Penner, Edward

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Cell damage and autoimmunity: A critical appraisal by Mackay, Ian R, Leskovsek, Natasha V, Rose, Noel R

“…Abstract In April 2007, an international Colloquium bridging scientific and clinical disciplines was held to discuss the role of cellular and tissue damage in…”
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The hepatitis-lupus connection by Mackay, I R

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International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis by Alvarez, F., Berg, P.A., Bianchi, F.B., Bianchi, L., Burroughs, A.K., Cancado, E.L., Chapman, R.W., Cooksley, W.G.E., Czaja, A.J., Desmet, V.J., Donaldson, P.T., Eddleston, A.L.W.F., Fainboim, L., Heathcote, J., Homberg, J.-C., Hoofnagle, J.H., Kakumu, S., Krawitt, E.L., Mackay, I.R., MacSween, R.N.M., Maddrey, W.C., Manns, M.P., McFarlane, I.G., Meyer zum Büschenfelde, K.-H., Mieli-Vergani, G., Nakanuma, Y., Nishioka, M., Penner, E., Porta, G., Portmann, B.C., Reed, W.D., Rodes, J., Schalm, S.W., Scheuer, P.J., Schrumpf, E., Seki, T., Toda, G., Tsuji, T., Tygstrup, N., Vergani, D., Zeniya, M.

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Topical anaesthetic effects on skin vasculature with potential implications for laser treatment by Tollan, Clare Josephine, MacLaren, William, Mackay, Iain R.

“…Laser treatment of vascular lesions is affected by parameters including the diameter and depth of the vessels and flow within the vessels. Topical anaesthetics…”
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IL-2 receptor alpha deficiency and features of primary biliary cirrhosis by Aoki, Christopher A., Roifman, Chaim M., Lian, Zhe-Xiong, Bowlus, Christopher L., Norman, Gary L., Shoenfeld, Yehuda, Mackay, Ian R., Eric Gershwin, M.

“…Congenital immune deficiency states have often been valuable experimental models of nature that have significantly enhanced our understanding of the immune…”
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Regulatory T cells in the prevention of mucosal inflammatory diseases: Patrolling the border by Lan, Ruth Y, Mackay, Ian R, Eric Gershwin, M

“…Abstract Regulatory T (Treg) cells are important contributors to the maintenance of immune tolerance in the periphery, and deficiency of Tregs is associated…”
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Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis by Rieger, Roman, Leung, Patrick S.C., Jeddeloh, Melissa R., Kurth, Mark J., Nantz, Michael H., Lam, Kit S., Barsky, Daniel, Ansari, Aftab A., Coppel, Ross L., Mackay, Ian R., Gershwin, M. Eric

“…Antimitochondrial antibodies (AMA) are unique among autoimmune serologic reactants because of their extremely high association with the index disease primary…”
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CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis by Shimoda, Shinji, Miyakawa, Hiroshi, Nakamura, Minoru, Ishibashi, Hiromi, Kikuchi, Kentaro, Kita, Hiroto, Niiro, Hiroaki, Arinobu, Youjirou, Ono, Nobuyuki, Mackay, Ian R, Gershwin, M. Eric, Akashi, Koichi

“…Abstract Approximately 5% of patients with primary biliary cirrhosis (PBC) lack characteristic anti-mitochondrial antibodies (AMA). Yet clinically AMA+ and…”
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Hepatoimmunology: A perspective by Mackay, Ian R

“…Premises for the subspecialty of hepatoimmunology include the recognition that the liver is a lymphoid organ with unique immunological properties. These…”
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The etiopathogenesis of autoimmunity by Mackay, Ian R

“…Acquisition by mammals of an adaptive immune system was an evolutionary leap, but occurred at the cost of autoimmunity. The necessity for self-recognition was…”
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From bases to basis: linking genetics to causation in primary biliary cirrhosis by Invernizzi, Pietro, Selmi, Carlo, Mackay, Ian R, Podda, Mauro, Gershwin, M Eric

“…Primary biliary cirrhosis (PBC) is a multifactorial autoimmune disease with inherited and environmental components in pathogenesis. It is exceptional among…”
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Autophagy: Highlighting a novel player in the autoimmunity scenario by Lleo, Ana, Invernizzi, Pietro, Selmi, Carlo, Coppel, Ross L, Alpini, Gianfranco, Podda, Mauro, Mackay, Ian R, Gershwin, M. Eric

“…Abstract Autophagy is a physiological cellular mechanism that degrades and recycles proteins and other molecules to maintain an adequate amino acid level…”
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The lymphoid liver: Considerations on pathways to autoimmune injury by Kita, Hiroto, Mackay, Ian R., van de Water, Judy, Gershwin, M. Eric

“…Immunologic injury in the liver involves immigrant T and B lymphocytes and a resident lymphoid population that comprises distinct lymphocytic cells and…”
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Primary biliary cirrhosis: an orchestrated immune response against epithelial cells by Gershwin, M. Eric, Ansari, Aftab A., Mackay, Ian R., Nakanuma, Yasuni, Nishio, Akiyoshi, Rowley, Merrill J., Coppel, Ross L.

“…Primary biliary cirrhosis (PBC) is an organ‐specific autoimmune disease that predominantly affects women and is characterized by chronic progressive…”
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Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization by Wakabayashi, K, Yoshida, K, Leung, P.S.C, Moritoki, Y, Yang, G.-X, Tsuneyama, K, Lian, Z.-X, Hibi, T, Ansari, A.A, Wicker, L.S, Ridgway, W.M, Coppel, R.L, Mackay, I.R, Gershwin, M.E

“…Our laboratory has suggested that loss of tolerance to pyruvate dehydrogenase (PDC-E2) leads to an anti-mitochondrial antibody response and autoimmune…”
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Cicaprost, an orally active prostacyclin analogue: its effects on platelet aggregation and skin blood flow in normal volunteers by Belch, JJ, McLaren, M, Lau, CS, Mackay, IR, Bancroft, A, McEwen, J, Thompson, JM

“…1. Prostacyclin (PGI2) and its analogues may be useful in peripheral vascular disease. However, most have to be given intravenously due to their metabolic…”
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