Search Results - "Mackay, I. R."

CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications by Whitmore, L., Mackay, R. I., van Herk, M., Korysko, P., Farabolini, W., Malyzhenkov, A., Corsini, R., Jones, R. M.

“…Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability…”
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Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications by Whitmore, L., Mackay, R. I., van Herk, M., Jones, J. K., Jones, R. M.

“…This paper presents the first demonstration of deeply penetrating dose delivery using focused very high energy electron (VHEE) beams using quadrupole magnets…”
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Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers by Harrington, K J, Billingham, L J, Brunner, T B, Burnet, N G, Chan, C S, Hoskin, P, Mackay, R I, Maughan, T S, Macdougall, J, McKenna, W G, Nutting, C M, Oliver, A, Plummer, R, Stratford, I J, Illidge, T

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Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons by Henthorn, N T, Warmenhoven, J W, Sotiropoulos, M, Aitkenhead, A H, Smith, E A K, Ingram, S P, Kirkby, N F, Chadwick, A L, Burnet, N G, Mackay, R I, Kirkby, K J, Merchant, M J

“…Relative Biological Effectiveness (RBE), the ratio of doses between radiation modalities to produce the same biological endpoint, is a controversial and…”
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Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization by Wakabayashi, K, Yoshida, K, Leung, P.S.C, Moritoki, Y, Yang, G.-X, Tsuneyama, K, Lian, Z.-X, Hibi, T, Ansari, A.A, Wicker, L.S, Ridgway, W.M, Coppel, R.L, Mackay, I.R, Gershwin, M.E

“…Our laboratory has suggested that loss of tolerance to pyruvate dehydrogenase (PDC-E2) leads to an anti-mitochondrial antibody response and autoimmune…”
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Shading correction algorithm for improvement of cone-beam CT images in radiotherapy by Marchant, T E, Moore, C J, Rowbottom, C G, MacKay, R I, Williams, P C

“…Cone-beam CT (CBCT) images have recently become an established modality for treatment verification in radiotherapy. However, identification of soft-tissue…”
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Epitope‐specific anti‐nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine‐dependent by Yang, C‐Y., Leung, P. S. C., Yang, G‐X., Kenny, T. P., Zhang, W., Coppel, R., Norman, G. L., Ansari, A. A., Mackay, I. R., Worman, H. J., Gershwin, M. E.

“…Summary Although the hallmark of primary biliary cirrhosis (PBC) is the presence of anti‐mitochondrial antibodies (AMA), a significant number of patients have…”
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Chronic complications and mortality in community-based patients with latent autoimmune diabetes in adults: the Fremantle Diabetes Study by Myhill, P., Davis, W. A., Bruce, D. G., Mackay, I. R., Zimmet, P., Davis, T. M. E.

“…Aims   To compare (i) the prevalence and incidence of chronic complications and (ii) cardiac and all‐cause mortality in community‐based patients with latent…”
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Molecular mimicry: a critical look at exemplary instances in human diseases by Rose, N R, Mackay, I R

“…Molecular mimicry, the concept that antigenic determinants of microorganisms resemble antigenic determinants of the host, is frequently cited as a plausible…”
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Daily monitoring of linear accelerator beam parameters using an amorphous silicon EPID by Budgell, G J, Zhang, R, Mackay, R I

“…An amorphous silicon EPID has been investigated to test its suitability as a daily check device for linac output and to provide daily monitoring of beam…”
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Islet autoantibodies in clinically diagnosed type 2 diabetes : Prevalence and relationship with metabolic control (UKPDS 70) by DAVIS, T. M. E, WRIGHT, A. D, MEHTA, Z. M, CULL, C. A, STRATTON, I. M, BOTTAZZO, G. F, BOSI, E, MACKAY, I. R, HOLMAN, R. R

“…We examined the prevalence of islet autoantibodies and their relationship to glycaemic control over 10 years in patients diagnosed clinically with new-onset…”
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Image Guidance for Proton Therapy by MacKay, R.I.

“…Image-guided radiotherapy has an established role in all forms of radiotherapy treatment delivery. Proton therapy seeks to deliver superior dose distributions…”
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IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71) by BOTTAZZO, G. F, BOSI, E, CULL, C. A, BONIFACIO, E, LOCATELLI, M, ZIMMET, P, MACKAY, I. R, HOLMAN, R. R

“…Established autoimmune markers of type 1 diabetes, including islet cell autoantibodies (ICA) and autoantibodies to glutamic acid decarboxylase (GADA) have been…”
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GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77 by Desai, M, Cull, C. A, Horton, V. A, Christie, M. R, Bonifacio, E, Lampasona, V, Bingley, P. J, Levy, J. C, Mackay, I. R, Zimmet, P, Holman, R. R, Clark, A

“…Aims/hypothesis Latent autoimmune diabetes in adults (LADA) is a slowly progressive form of autoimmune diabetes, with autoantibodies to islet proteins…”
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International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis by Alvarez, F., Berg, P.A., Bianchi, F.B., Bianchi, L., Burroughs, A.K., Cancado, E.L., Chapman, R.W., Cooksley, W.G.E., Czaja, A.J., Desmet, V.J., Donaldson, P.T., Eddleston, A.L.W.F., Fainboim, L., Heathcote, J., Homberg, J.-C., Hoofnagle, J.H., Kakumu, S., Krawitt, E.L., Mackay, I.R., MacSween, R.N.M., Maddrey, W.C., Manns, M.P., McFarlane, I.G., Meyer zum Büschenfelde, K.-H., Mieli-Vergani, G., Nakanuma, Y., Nishioka, M., Penner, E., Porta, G., Portmann, B.C., Reed, W.D., Rodes, J., Schalm, S.W., Scheuer, P.J., Schrumpf, E., Seki, T., Toda, G., Tsuji, T., Tygstrup, N., Vergani, D., Zeniya, M.

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Assessment of burn depth: A prospective, blinded comparison of laser Doppler imaging and videomicroscopy by McGill, D.J, Sørensen, K, MacKay, I.R, Taggart, I, Watson, S.B

“…Abstract Introduction and aims There is a need, both in clinical and research settings, for an affordable, objective method of assessing burn depth. This study…”
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A novel imaging technique for fusion of high-quality immobilised MR images of the head and neck with CT scans for radiotherapy target delineation by WEBSTER, G. J, KILGALLON, J. E, HO, K. F, ROWBOTTOM, C. G, SLEVIN, N. J, MACKAY, R. I

“…Uncertainty and inconsistency are observed in target volume delineation in the head and neck for radiotherapy treatment planning based only on CT imaging…”
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Autoantibodies to glutamic acid decarboxylase in diabetic patients from a multi-ethnic Australian community: the Fremantle Diabetes Study by Davis, T. M. E., Zimmet, P., Davis, W. A., Bruce, D. G., Fida, S., Mackay, I. R.

“…SUMMARY Aims  To investigate ethnic/racial differences in the prevalence of serum antibodies to glutamic acid decarboxylase (GADA) and ICA512/IA‐2 in diabetic…”
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Determining the parameter space for effective oxygen depletion for FLASH radiation therapy by Rothwell, B C, Kirkby, N F, Merchant, M J, Chadwick, A L, Lowe, M, Mackay, R I, Hendry, J H, Kirkby, K J

“…There has been a recent revival of interest in the FLASH effect, after experiments have shown normal tissue sparing capabilities of ultra-high-dose-rate…”
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The effect of ambient temperature on capillary vascular malformations by McGill, D.J., Mackay, I.R.

“…Summary Background  Following pulsed dye laser (PDL) treatment of capillary vascular malformations (CMs), the capillaries left behind tend to be smaller and…”
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