Search Results - "Macip, Salvador"

Introduction: Transhumanism. Beyond the body by Salvador Macip

“…Science allows us to understand the world we live in. Centuries of research have helped us learn more about our place in the universe, and we have discovered a…”
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Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker by Poblocka, Marta, Bassey, Akang Leonard, Smith, Victoria M., Falcicchio, Marta, Manso, Ana Sousa, Althubiti, Mohammad, Sheng, XiaoBo, Kyle, Andrew, Barber, Ruth, Frigerio, Mark, Macip, Salvador

“…A wide range of diseases have been shown to be influenced by the accumulation of senescent cells, from fibrosis to diabetes, cancer, Alzheimer’s and other…”
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Effects of Fasting on THP1 Macrophage Metabolism and Inflammatory Profile by Rius-Bonet, Julia, Macip, Salvador, Massip-Salcedo, Marta, Closa, Daniel

“…Fasting can affect the body's inflammatory response, and this has been linked to potential health benefits, including improvements for people with rheumatic…”
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A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6 by Dhokia, Vinesh, Macip, Salvador

“…Retinoids are a group of vitamin A-related chemicals that are essential to chordate mammals. They regulate a number of basic processes, including embryogenesis…”
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Hesitation about coronavirus vaccines in healthcare professionals and general population in Spain by Saigí-Rubió, Francesc, Eguia, Hans, Espelt, Albert, Macip, Salvador, Bosque-Prous, Marina

“…This study attempts to provide a picture of the hesitancy to vaccination against COVID-19 in Spain during the 2021 spring-autumn vaccination campaign, both in…”
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Hesitation about coronavirus vaccines in healthcare professionals and general population in Spain by Francesc Saigí-Rubió, Hans Eguia, Albert Espelt, Salvador Macip, Marina Bosque-Prous

“…BackgroundThis study attempts to provide a picture of the hesitancy to vaccination against COVID-19 in Spain during the 2021 spring-autumn vaccination…”
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PML-II regulates ERK and AKT signal activation and IFNα-induced cell death by Meng, Xueqiong, Chen, Yixiang, Macip, Salvador, Leppard, Keith

“…The requirement of promyelocytic leukaemia protein (PML) in interferon (IFN)-induced cell apoptosis is well-established. However, the exact mechanisms by which…”
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Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer by Falcicchio, Marta, Ward, Jake A., Macip, Salvador, Doveston, Richard G.

“…Most cancers evolve to disable the p53 pathway, a key tumour suppressor mechanism that prevents transformation and malignant cell growth. However, only ~50%…”
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Individual Freedom in the Initial Response to Covid-19 by Macip, Salvador, Yuguero, Oriol

“…The COVID-19 pandemic has been a phenomenal challenge to global health care and will continue to be so in the upcoming months. Beyond its medical toll,…”
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Efficacy of Vemurafenib in Hairy-Cell Leukemia by Samuel, Jesvin, Macip, Salvador, Dyer, Martin J.S

“…The authors report a case of purine analogue–refractory hairy-cell leukemia with biallelic BRAF V600E mutations and a high leukemic burden that was treated…”
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Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma by Smith, Victoria M, Dietz, Anna, Henz, Kristina, Bruecher, Daniela, Jackson, Ross, Kowald, Lisa, van Wijk, Sjoerd J L, Jayne, Sandrine, Macip, Salvador, Fulda, Simone, Dyer, Martin J S, Vogler, Meike

“…The BCL-2-specific inhibitor, ABT-199 (venetoclax) has exhibited remarkable clinical activity in nearly all cases of chronic lymphocytic leukemia. In contrast,…”
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Transcriptional role of p53 in interferon-mediated antiviral immunity by Muñoz-Fontela, César, Macip, Salvador, Martínez-Sobrido, Luis, Brown, Lauren, Ashour, Joseph, García-Sastre, Adolfo, Lee, Sam W, Aaronson, Stuart A

“…Tumor suppressor p53 is activated by several stimuli, including DNA damage and oncogenic stress. Previous studies (Takaoka, A., S. Hayakawa, H. Yanai, D…”
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Differences in the molecular profile of endometrial cancers from British White and British South Asian women by Polymeros, Konstantinos, Guttery, David S, Hew, Roger, Bishop, Rachael, Stannard, Elizabeth, Macip, Salvador, Symonds, Paul, Moss, Esther L

“…Objectives To identify differences in the mutational profile of endometrial tumours between British White (BW) and South Asian (BSA) women. Methods We analysed…”
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An Appraisal on the Value of Using Nutraceutical Based Senolytics and Senostatics in Aging by Kaur, Amanpreet, Macip, Salvador, Stover, Cordula M

“…The average human life expectancy has increased globally, and continues to rise, owing to the substantive progress made in healthcare, medicine, sanitation,…”
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poly(I:C) synergizes with proteasome inhibitors to induce apoptosis in cervical cancer cells by Meng, Xueqiong, Cui, Xiaoxi, Shao, Xiaoya, Liu, Yanqi, Xing, Yihao, Smith, Victoria, Xiong, Shiqiu, Macip, Salvador, Chen, Yixiang

“…•poly(I:C) and proteasome inhibitors induce cell death in cervical cancer cells by activating multiple pro-apoptotic mechanisms.•The combination of both…”
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Reactive Oxygen Species and Mitochondrial Sensitivity to Oxidative Stress Determine Induction of Cancer Cell Death by p21 by Masgras, Ionica, Carrera, Samantha, de Verdier, Petra J., Brennan, Paul, Majid, Aneela, Makhtar, Wan, Tulchinsky, Eugene, Jones, George D.D., Roninson, Igor B., Macip, Salvador

“…p21Waf1/Cip1/Sdi1 is a cyclin-dependent kinase inhibitor that mediates cell cycle arrest. Prolonged p21 up-regulation induces a senescent phenotype in normal…”
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Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions by Macip, Salvador, Igarashi, Makoto, Berggren, Petra, Yu, Jian, Lee, Sam W., Aaronson, Stuart A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The role of the HIF-1α transcription factor in increased cell division at physiological oxygen tensions by Carrera, Samantha, Senra, Joana, Acosta, Maria Isabel, Althubiti, Mohammad, Hammond, Ester M, de Verdier, Petra J, Macip, Salvador

“…HIF-1 is a transcription factor that mediates the cellular responses to low oxygen environments, mainly as a result of having an oxygen-labile subunit, HIF-1α…”
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ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway by Lee, Sam W, Ohtsuka, Takao, Ryu, Hoon, Minamishima, Yohji A, Macip, Salvador, Sagara, Junji, Nakayama, Keiichi I, Aaronson, Stuart A

“…The apoptosis-associated speck-like protein (ASC) is an unusual adaptor protein that contains the Pyrin/PAAD death domain in addition to the CARD…”
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HB-EGF is a potent inducer of tumor growth and angiogenesis by ONGUSAHA, Pat P, KWAK, Jennifer C, ZWIBLE, Andrew J, MACIP, Salvador, HIGASHIYAMA, Shigeki, TANIGUCHI, Naoyuki, LI FANG, LEE, Sam W

“…Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has been shown to stimulate the growth of a variety of cells in an autocrine or paracrine…”
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