Search Results - "Maciewicz, R A"

The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung by Fujimori, T, Grabiec, A M, Kaur, M, Bell, T J, Fujino, N, Cook, P C, Svedberg, F R, MacDonald, A S, Maciewicz, R A, Singh, D, Hussell, T

“…Much of the biology surrounding macrophage functional specificity has arisen through examining inflammation-induced polarizing signals, but this also occurs in…”
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Measurement and visualisation of focal cartilage thickness change by MRI in a study of knee osteoarthritis using a novel image analysis tool by WILLIAMS, T. G, HOLMES, A. P, BOWES, M, VINCENT, G, HUTCHINSON, C. E, WATERTON, J. C, MACIEWICZ, R. A, TAYLOR, C. J

“…We describe the application of a novel analysis method that provides detailed maps of changes in cartilage thickness measured from MRI scans for individuals…”
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Radiographic assessment of the index to ring finger ratio (2D:4D) in adults by Robertson, J., Zhang, W., Liu, J. J., Muir, K. R., Maciewicz, R. A., Doherty, M.

“…The smaller index to ring finger (2D:4D) ratio has been considered as a ‘male finger pattern’ and is associated with sporting ability and a number of…”
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No loss of cartilage volume over three years in patients with knee osteoarthritis as assessed by magnetic resonance imaging by Gandy, S.J., Dieppe, P.A., Keen, M.C., Maciewicz, R.A., Watt, I., Waterton, J.C.

“…Objective Magnetic resonance imaging (MRI) has the potential to provide accurate quantification of structural changes in joint disease, with sensitivity to…”
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Does Chondrocalcinosis Associate With a Distinct Radiographic Phenotype of Osteoarthritis in Knees and Hips? A Case–Control Study by Abhishek, A., Doherty, S., Maciewicz, R. A., Muir, K., Zhang, W., Doherty, M.

“…Objective To examine if knee chondrocalcinosis (CC), hip CC, or CC at distant joints associates with a distinct radiographic phenotype of osteoarthritis (OA)…”
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Use of statins is associated with a lower prevalence of generalised osteoarthritis by Valdes, A M, Zhang, W, Muir, K, Maciewicz, R A, Doherty, S, Doherty, M

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Characterisation of the guinea pig model of osteoarthritis by in vivo three-dimensional magnetic resonance imaging by Tessier, J.J, Bowyer, J, Brownrigg, N.J, Peers, I.S, Westwood, F.R, Waterton, J.C, Maciewicz, R.A

“…Objective: To characterise longitudinal changes in joint integrity and cartilage volume in vivo in the guinea pig spontaneous osteoarthritis (OA) model by…”
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Lifetime body mass index, other anthropometric measures of obesity and risk of knee or hip osteoarthritis in the GOAL case-control study by Holliday, K.L, McWilliams, D.F, Maciewicz, R.A, Muir, K.R, Zhang, W, Doherty, M

“…Summary Objective To examine the risk of large joint osteoarthritis (OA) in those becoming overweight during early adult life, and to assess the risks…”
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Measurement of cartilage volumes in rheumatoid arthritis using MRI by GANDY, S. J, BRETT, A. D, DIEPPE, P. A, KEEN, M. C, MACIEWICZ, R. A, TAYLOR, C. J, WATERTON, J. C, WATT, I

“…MRI is a valuable imaging modality for assessment of the articular cartilage in rheumatoid arthritis (RA) and is potentially of use in monitoring disease…”
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Magnetic resonance imaging measurement of knee cartilage volume in a multicentre study by Morgan, S. R., Waterton, J. C., Maciewicz, R. A., Leadbetter, J. E., Gandy, S. J., Moots, R. J., Creamer, P., Nash, A. F. P.

“…Objective. To investigate the variability between different high-field scanners in magnetic resonance imaging (MRI) measurement of knee cartilage volume in…”
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Diurnal variation in the femoral articular cartilage of the knee in young adult humans by Waterton, John C., Solloway, Stuart, Foster, John E., Keen, Michael C., Gandy, Stephen, Middleton, Brian J., Maciewicz, Rose A., Watt, Iain, Dieppe, Paul A., Taylor, Christopher J.

“…Our objective was to test the hypothesis that diurnal changes occur in thickness or volume of the femoral articular cartilage of the knee in asymptomatic young…”
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Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene by Warner, S.C., Walsh, D.A., Laslett, L.L., Maciewicz, R.A., Soni, A., Hart, D.J., Zhang, W., Muir, K.R., Dennison, E.M., Leaverton, P., Rampersaud, E., Cooper, C., Spector, T.D., Cicuttini, F.M., Arden, N.K., Jones, G., Doherty, M., Valdes, A.M.

“…Background Substance P (SP) is a pain‐ and inflammation‐related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK1). SP and NK1…”
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Quantitative magnetic resonance imaging of the knee: a method of measuring response to intra-articular treatments by Creamer, P, Keen, M, Zananiri, F, Waterton, J C, Maciewicz, R A, Oliver, C, Dieppe, P, Watt, I

“…OBJECTIVES To investigate the potential of quantitative magnetic resonance imaging (MRI) to differentiate between therapeutically induced changes in…”
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Distribution of aggrecanase (ADAMts 4/5) cleavage products in normal and osteoarthritic human articular cartilage: The influence of age, topography and zone of tissue by Bayliss, M.T., Hutton, S., Hayward, J., Maciewicz, R.A.

“…Objective To develop and characterize a polyclonal antiserum (RAM 3.2), which recognizes the neo-C terminal cleavage product generated by the action of…”
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Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity by Mercuri, F A, Maciewicz, R A, Tart, J, Last, K, Fosang, A J

“…We have expressed G1-G2 mutants with amino acid changes at the DIPEN(341) downward arrow(342)FFGVG and ITEGE(373) downward arrow(374)ARGSV cleavage sites, in…”
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Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis by Mapp, P.I, Walsh, D.A, Bowyer, J, Maciewicz, R.A

“…Summary Objective To investigate the effects of a matrix metalloproteinase (MMP) inhibitor on joint pathology and pain behavior in the rat meniscal transection…”
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Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis by Neogi, T, Soni, A, Doherty, S A, Laslett, L L, Maciewicz, R A, Hart, D J, Zhang, W, Muir, K R, Wheeler, M, Cooper, C, Spector, T D, Cicuttini, F, Jones, G, Nevitt, M, Liu, Y, Arden, N K, Doherty, M, Valdes, A M

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Can cartilage loss be detected in knee osteoarthritis (OA) patients with 3-6 months' observation using advanced image analysis of 3T MRI? by Hunter, D J, Bowes, M A, Eaton, C B, Holmes, A P, Mann, H, Kwoh, C K, Maciewicz, R A, Samuels, J, Waterton, J C

“…Prior investigations of magnetic resonance imaging (MRI) biomarkers of cartilage loss in knee osteoarthritis (OA) suggest that trials of interventions which…”
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Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D by Van Der Stappen, Jos W. J., Williams, Ann C., Maciewicz, Rose A., Paraskeva, Christos

“…The aim of our study was to identify changes in secreted procathepsin B levels in a model of the human colorectal adenoma to carcinoma sequence and to…”
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Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case–control population (the GOAL study) by Limer, K.L., Ph.D, Tosh, K., Ph.D, Bujac, S.R., M.Sc, McConnell, R., M.S.C.I, Doherty, S., S.R.N, Nyberg, F., Ph.D., M.D, Zhang, W., Ph.D, Doherty, M., M.D, Muir, K.R., Ph.D, Maciewicz, R.A., Ph.D

“…Summary Objective Published studies have tested over 90 genes for association with osteoarthritis (OA), but few positives reported have been independently…”
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