Tumoural form of Whipple's disease simulating carcinomatosis

Whipple's disease is a rare disease caused by the actinomycete bacteria Tropheryma whipplei, which cause intestinal infection. The most common symptoms are chronic diarrhoea, weight loss, abdominal pain, arthritis and neurological abnormalities, which can be fatal. This paper reports a case of...

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Bibliographic Details
Published in:	The Brazilian journal of infectious diseases Vol. 18; no. 3; pp. 346 - 349
Main Authors:	Martins Costa, Jamille Hemétrio Salles, Maciel, Aline Bussinger, de Navarro Guimarães Godinho, Matheus, de Paula, Rafaela Brito, Gotardelo, Daniel Riani
Format:	Journal Article
Language:	English
Published:	Brazil Elsevier Editora Ltda 01-05-2014 Contexto Elsevier Brazilian Society of Infectious Diseases
Subjects:	Anti-Bacterial Agents - therapeutic use Carcinoma - diagnosis Carcinomatosis Care and treatment Case Report Case studies Ceftriaxone - therapeutic use Diagnosis Diagnosis, Differential Female Humans INFECTIOUS DISEASES Middle Aged Tropheryma - isolation & purification Tropheryma whipplei Whipple Disease - diagnosis Whipple Disease - drug therapy Whipple's disease Carcinomatosis Tropheryma whipplei Whipple's disease
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Summary:	Whipple's disease is a rare disease caused by the actinomycete bacteria Tropheryma whipplei, which cause intestinal infection. The most common symptoms are chronic diarrhoea, weight loss, abdominal pain, arthritis and neurological abnormalities, which can be fatal. This paper reports a case of a 57-year-old Brazilian woman with diarrhoea, vomiting, abdominal pain, appetite loss, intermittent fever, malaise, weight loss and malnutrition. Migratory polyarthralgia and recurrent visual scotomas preceded the symptoms. The retroperitoneal pseudotumour formation finding was associated with prolonged wasting syndrome, which did not respond to usual therapies, thus leading to the investigation of carcinomatosis disease. After laparotomy, biopsy and histochemical study of the lesions with negative results for malignancy, we proceeded to the investigation of Whipple's disease, which was then confirmed. The patient improved clinically and started gaining weight after using ceftriaxone (IV).
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1413-8670 1678-4391 1678-4391
DOI:	10.1016/j.bjid.2014.01.006