Search Results - "Macias, Maria J"

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors by Martin-Malpartida, Pau, Batet, Marta, Kaczmarska, Zuzanna, Freier, Regina, Gomes, Tiago, Aragón, Eric, Zou, Yilong, Wang, Qiong, Xi, Qiaoran, Ruiz, Lidia, Vea, Angela, Márquez, José A., Massagué, Joan, Macias, Maria J.

“…Smad transcription factors activated by TGF-β or by BMP receptors form trimeric complexes with Smad4 to target specific genes for cell fate regulation. The…”
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A Smad action turnover switch operated by WW domain readers of a phosphoserine code by Aragón, Eric, Goerner, Nina, Zaromytidou, Alexia-Ileana, Xi, Qiaoran, Escobedo, Albert, Massagué, Joan, Macias, Maria J

“…When directed to the nucleus by TGF-β or BMP signals, Smad proteins undergo cyclin-dependent kinase 8/9 (CDK8/9) and glycogen synthase kinase-3 (GSK3)…”
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ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling by Wright, Roni H. G., Lioutas, Antonios, Le Dily, Francois, Soronellas, Daniel, Pohl, Andy, Bonet, Jaume, Nacht, A. S., Samino, Sara, Font-Mateu, Jofre, Vicent, Guillermo P., Wierer, Michael, Trabado, Miriam A., Schelhorn, Constanze, Carolis, Carlo, Macias, Maria J., Yanes, Oscar, Oliva, Baldo, Beato, Miguel

“…Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by…”
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Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-β Pathways by Aragón, Eric, Goerner, Nina, Xi, Qiaoran, Gomes, Tiago, Gao, Sheng, Massagué, Joan, Macias, Maria J.

“…Transforming growth factor (TGF)-β and BMP signaling is mediated by Smads 1–5 (R-Smads and Co-Smads) and inhibited by Smad7, a major hub of regulation of TGF-β…”
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Structural Basis of the Activation and Degradation Mechanisms of the E3 Ubiquitin Ligase Nedd4L by Escobedo, Albert, Gomes, Tiago, Aragón, Eric, Martín-Malpartida, Pau, Ruiz, Lidia, Macias, Maria J.

“…We investigated the mechanisms of activation and degradation of the E3 ubiquitin ligase Nedd4L combining the available biochemical information with…”
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Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α by Pous, Joan, Baginski, Blazej, Martin-Malpartida, Pau, González, Lorena, Scarpa, Margherita, Aragon, Eric, Ruiz, Lidia, Mees, Rebeca A., Iglesias-Fernández, Javier, Orozco, Modesto, Nebreda, Angel R., Macias, Maria J.

“…Many functional aspects of the protein kinase p38α have been illustrated by more than three hundred structures determined in the presence of reducing agents…”
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Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1 by Pluta, Radoslaw, Aragón, Eric, Prescott, Nicholas A., Ruiz, Lidia, Mees, Rebeca A., Baginski, Blazej, Flood, Julia R., Martin-Malpartida, Pau, Massagué, Joan, David, Yael, Macias, Maria J.

“…Forkhead box H1 (FoxH1) is an essential maternal pioneer factor during embryonic development that binds to specific GG/GT-containing DNA target sequences. Here…”
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Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease by Rol, Álvaro, Todorovski, Toni, Martin-Malpartida, Pau, Escolà, Anna, Gonzalez-Rey, Elena, Aragón, Eric, Verdaguer, Xavier, Vallès-Miret, Mariona, Farrera-Sinfreu, Josep, Puig, Eduard, Fernández-Carneado, Jimena, Ponsati, Berta, Delgado, Mario, Riera, Antoni, Macias, Maria J.

“…Ulcerative colitis and Crohn’s disease are forms of inflammatory bowel disease whose incidence and prevalence are increasing worldwide. These diseases lead to…”
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Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway by González, Lorena, Díaz, Lucía, Pous, Joan, Baginski, Blazej, Duran-Corbera, Anna, Scarpa, Margherita, Brun-Heath, Isabelle, Igea, Ana, Martin-Malpartida, Pau, Ruiz, Lidia, Pallara, Chiara, Esguerra, Mauricio, Colizzi, Francesco, Mayor-Ruiz, Cristina, Biondi, Ricardo M., Soliva, Robert, Macias, Maria J., Orozco, Modesto, Nebreda, Angel R.

“…p38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of p38α…”
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DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription by Sancho, Ana, Duran, Jordi, García-España, Antonio, Mauvezin, Caroline, Alemu, Endalkachew A, Lamark, Trond, Macias, Maria J, DeSalle, Rob, Royo, Miriam, Sala, David, Chicote, Javier U, Palacín, Manuel, Johansen, Terje, Zorzano, Antonio

“…Human DOR/TP53INP2 displays a unique bifunctional role as a modulator of autophagy and gene transcription. However, the domains or regions of DOR that…”
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WW and SH3 domains, two different scaffolds to recognize proline-rich ligands by Macias, Maria J., Wiesner, Silke, Sudol, Marius

“…WW domains are small protein modules composed of approximately 40 amino acids. These domains fold as a stable, triple stranded β-sheet and recognize…”
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Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation by Fernandez-Chamorro, Javier, Piñeiro, David, Gordon, James M. B., Ramajo, Jorge, Francisco-Velilla, Rosario, Macias, Maria J., Martinez-Salas, Encarnación

“…Ribonucleic acid (RNA)-binding proteins are key players of gene expression control. We have shown that Gemin5 interacts with internal ribosome entry site…”
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Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements by Zhou, Rui, Maisuradze, Gia G., Suñol, David, Todorovski, Toni, Macias, Maria J., Xiao, Yi, Scheraga, Harold A., Czaplewski, Cezary, Liwo, Adam

“…To demonstrate the utility of the coarse-grained united-residue (UNRES) force field to compare experimental and computed kinetic data for folding proteins, we…”
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Structural determinants of Smad function in TGF-β signaling by Macias, Maria J., Martin-Malpartida, Pau, Massagué, Joan

“…•Smad proteins are highly conserved in metazoans.•Smad structures illuminate the impact of polymorphisms and cancer mutations.•Many tumor mutations cluster at…”
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Conformational landscape of multidomain SMAD proteins by Gomes, Tiago, Martin-Malpartida, Pau, Ruiz, Lidia, Aragón, Eric, Cordeiro, Tiago N., Macias, Maria J.

“…[Display omitted] SMAD transcription factors, the main effectors of the TGFβ (transforming growth factor β) network, have a mixed architecture of globular…”
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Preventing fibril formation of a protein by selective mutation by Maisuradze, Gia G., Medina, Jordi, Kachlishvili, Khatuna, Krupa, Pawel, Mozolewska, Magdalena A., Martin-Malpartida, Pau, Maisuradze, Luka, Macias, Maria J., Scheraga, Harold A.

“…The origins of formation of an intermediate state involved in amyloid formation and ways to prevent it are illustrated with the example of the Formin binding…”
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First Generic Teriparatide: Structural and Biological Sameness to Its Reference Medicinal Product by Fernández-Carneado, Jimena, Vallès-Miret, Mariona, Arrastia-Casado, Sílvia, Almazán-Moga, Ana, Macias, Maria J, Martin-Malpartida, Pau, Vilaseca, Marta, Díaz-Lobo, Mireia, Vazquez, Mayte, Sanahuja, Rosa M, Gambús, Gemma, Ponsati, Berta

“…Teriparatide is an anabolic peptide drug indicated for the treatment of osteoporosis. Recombinant teriparatide was first approved in 2002 and has since been…”
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Conformational ensemble of the TNF-derived peptide solnatide in solution by Martin-Malpartida, Pau, Arrastia-Casado, Silvia, Farrera-Sinfreu, Josep, Lucas, Rudolf, Fischer, Hendrik, Fischer, Bernhard, Eaton, Douglas C., Tzotzos, Susan, Macias, Maria J.

“…[Display omitted] •Solnatide is a 17-mer cyclic peptide.•The cyclic peptide mimics the sequence and function of the lectin-like domain of human TNF.•Solnatide…”
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Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins by Freier, Regina, Aragón, Eric, Bagiński, Błażej, Pluta, Radoslaw, Martin-Malpartida, Pau, Ruiz, Lidia, Condeminas, Miriam, Gonzalez, Cayetano, Macias, Maria J

“…Thioredoxins (Trxs) are ubiquitous enzymes that regulate the redox state in cells. In , there are two germline-specific Trxs, Deadhead (Dhd) and thioredoxin T…”
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Correction to “De Novo Engineering of Pd-Metalloproteins and Their Use as Intracellular Catalysts” by Learte-Aymamí, Soraya, Martínez-Castro, Laura, González-González, Carmen, Condeminas, Miriam, Martin-Malpartida, Pau, Tomás-Gamasa, María, Baúlde, Sandra, Couceiro, José R., Maréchal, Jean-Didier, Macias, Maria J., Mascareñas, José L., Vázquez, M. Eugenio

“…[This corrects the article DOI: 10.1021/jacsau.4c00379.]…”
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