Search Results - "Machwirth, Markus"
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The roles of different forms of IL-15 in human melanoma progression
Published in Frontiers in immunology (02-06-2023)“…Melanoma is a lethal skin cancer, and the risk of developing it is increased by exposure to ultraviolet (UV) radiation. The production of cytokines such as…”
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A highly soluble Sleeping Beauty transposase improves control of gene insertion
Published in Nature biotechnology (01-12-2019)“…The Sleeping Beauty (SB) transposon system is an efficient non-viral gene transfer tool in mammalian cells, but its broad use has been hampered by uncontrolled…”
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Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
Published in Cell metabolism (04-04-2023)“…The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT). Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial…”
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CAR T cells targeting Aspergillus fumigatus are effective at treating invasive pulmonary aspergillosis in preclinical models
Published in Science translational medicine (28-09-2022)“…is a ubiquitous mold that can cause severe infections in immunocompromised patients, typically manifesting as invasive pulmonary aspergillosis (IPA). Adaptive…”
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