Search Results - "Machulkin, Aleksei E"

The Importance of Linkers in the Structure of PSMA Ligands by Uspenskaya, Anastasia A, Nimenko, Ekaterina A, Machulkin, Aleksei E, Beloglazkina, Elena K, Majouga, Alexander G

“…Cancer is one of the leading social problems of the modern world. Today prostate cancer is the second leading cause of cancer deaths among men. Targeted drug…”
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Synthesis and Preclinical Evaluation of Small-Molecule Prostate-Specific Membrane Antigen-Targeted Abiraterone Conjugate by Machulkin, Aleksei E, Nimenko, Ekaterina A, Zyk, Nikolay U, Uspenskaia, Anastasiia A, Smirnova, Galina B, Khan, Irina I, Pokrovsky, Vadim S, Vaneev, Alexander N, Timoshenko, Roman V, Mamed-Nabizade, Vugara V, Zavertkina, Maria V, Erofeev, Alexander, Gorelkin, Petr, Majouga, Alexander G, Zyk, Nikolay V, Khazanova, Elena S, Beloglazkina, Elena K

“…Prostate cancer is the second most common type of cancer among men. The main method of its treatment is androgen deprivation therapy, which has a wide range of…”
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Fluorescent Conjugates Based on Prostate-Specific Membrane Antigen Ligands as an Effective Visualization Tool for Prostate Cancer by Uspenskaia, Anastasiia A., Krasnikov, Pavel A., Beloglazkina, Elena K., Machulkin, Aleksei E.

“…Fluorescent dyes are widely used in histological studies and in intraoperative imaging, including surgical treatment of prostate cancer (PC), which is one of…”
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Synthesis, 123I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures by Hasnowo, Lutfi A., Larkina, Maria S., Plotnikov, Evgenii, Bodenko, Vitalina, Yuldasheva, Feruza, Stasyuk, Elena, Petrov, Stanislav A., Zyk, Nikolai Y., Machulkin, Aleksei E., Vorozhtsov, Nikolai I., Beloglazkina, Elena K., Nenajdenko, Valentine G., Tolmachev, Vladimir, Orlova, Anna, Majouga, Alexander G., Yusubov, Mekhman S.

“…Prostate-specific membrane antigen (PSMA) has been identified as a target for the development of theranostic agents. In our current work, we describe the…”
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Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen by Petrov, Stanislav A, Machulkin, Aleksei E, Uspenskaya, Anastasia A, Zyk, Nikolay Y, Nimenko, Ekaterina A, Garanina, Anastasia S, Petrov, Rostislav A, Polshakov, Vladimir I, Grishin, Yuri K, Roznyatovsky, Vitaly A, Zyk, Nikolay V, Majouga, Alexander G, Beloglazkina, Elena K

“…A strategy for stereoselective synthesis of molecular platform for targeted delivery of bimodal therapeutic or theranostic agents to the prostate-specific…”
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Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates by Zyk, Nikolai Y, Garanina, Anastasiia S, Plotnikova, Ekaterina A, Ber, Anton P, Nimenko, Ekaterina A, Dashkova, Natalia S, Uspenskaia, Anastasiia A, Shafikov, Radik R, Skvortsov, Dmitry A, Petrov, Stanislav A, Pankratov, Andrey A, Zyk, Nikolai V, Majouga, Alexander G, Beloglazkina, Elena K, Machulkin, Aleksei E

“…Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable…”
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Optimization of the dipeptide motifs in the PSMA ligands linker structure: synthesis and in vitro evaluation by Uspenskaya, Anastasiia A., Nimenko, Ekaterina A., Shafikov, Radik R., Zyk, Nikolay Y., Evteev, Sergei A., Dashkova, Natalia S., Ivanenkov, Yan A., Majouga, Alexander G., Skvortsov, Dmitry A., Garanina, Anastasiia S., Beloglazkina, Elena K., Machulkin, Aleksei E.

“…An improved series of ligands targeting prostatic specific membrane antigen has been reported. Varying compounds and their biological parameters were due to…”
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PSMA-targeted low-molecular double conjugates for diagnostics and therapy by Petrov, Stanislav A., Zyk, Nikolay Y., Machulkin, Aleksei E., Beloglazkina, Elena K., Majouga, Alexander G.

“…This review presents data on dual conjugates of therapeutic and diagnostic action for targeted delivery to prostate cancer cells. The works of the last ten…”
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Pentamethine cyanine dyes with alkynyl group as perspective structure for conjugation with targeting moiety by Uspenskaia, Anastasiia A., Doroshenko, Irina A., Popovicheva, Kseniia A., Shmychkov, Nazar V., Pryakhina, Ekaterina V., Shafikov, Radik R., Skvortsov, Dmitrii A., Beklemishev, Mikhail K., Zaborova, Olga V., Podrugina, Tatiana A., Machulkin, Aleksei E., Beloglazkina, Elena K.

“…[Display omitted] •An asymmetric carbocyanine for the [3+2] cycloaddition reaction was obtained.•A triazole ring does not affect the photophysical properties…”
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Synthesis and Biological Evaluation of PSMA Ligands with Aromatic Residues and Fluorescent Conjugates Based on Them by Machulkin, Aleksei E, Shafikov, Radik R, Uspenskaya, Anastasia A, Petrov, Stanislav A, Ber, Anton P, Skvortsov, Dmitry A, Nimenko, Ekaterina A, Zyk, Nikolay U, Smirnova, Galina B, Pokrovsky, Vadim S, Abakumov, Maxim A, Saltykova, Irina V, Akhmirov, Rauf T, Garanina, Anastasiia S, Polshakov, Vladimir I, Saveliev, Oleg Y, Ivanenkov, Yan A, Aladinskaya, Anastasiya V, Finko, Alexander V, Yamansarov, Emil U, Krasnovskaya, Olga O, Erofeev, Alexander S, Gorelkin, Petr V, Dontsova, Olga A, Beloglazkina, Elena K, Zyk, Nikolay V, Khazanova, Elena S, Majouga, Alexander G

“…Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), is a suitable target for specific delivery of antitumor drugs…”
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Synthesis and initial in vitro evaluation of PSMA-targeting ligands with a modified aromatic moiety at the lysine ε-nitrogen atom by Zyk, Nikolai Y., Ber, Anton P., Nimenko, Ekaterina A., Shafikov, Radik R., Evteev, Sergei A., Petrov, Stanislav A., Uspenskaya, Anastasia A., Dashkova, Natalia S., Ivanenkov, Yan A., Skvortsov, Dmitry A., Beloglazkina, Elena K., Majouga, Alexander G., Machulkin, Aleksei E.

“…[Display omitted] We report an improved series of ligands targeting prostate specific membrane antigen (PSMA). The new compounds were designed by the…”
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Synthesis, Characterization, and Preclinical Evaluation of a Small-Molecule Prostate-Specific Membrane Antigen-Targeted Monomethyl Auristatin E Conjugate by Machulkin, Aleksei E, Uspenskaya, Anastasia A, Zyk, Nikolay U, Nimenko, Ekaterina A, Ber, Anton P, Petrov, Stanislav A, Polshakov, Vladimir I, Shafikov, Radik R, Skvortsov, Dmitry A, Plotnikova, Ekaterina A, Pankratov, Andrei A, Smirnova, Galina B, Borisova, Yulia A, Pokrovsky, Vadim S, Kolmogorov, Vasilii S, Vaneev, Alexander N, Khudyakov, Alexander D, Chepikova, Olga E, Kovalev, Sergey, Zamyatnin Jr, Andrey A, Erofeev, Alexander, Gorelkin, Petr, Beloglazkina, Elena K, Zyk, Nikolay V, Khazanova, Elena S, Majouga, Alexander G

“…Prostate cancer is the second most common type of cancer among men. Its main method of treatment is chemotherapy, which has a wide range of side effects. One…”
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PSMA-targeted small-molecule docetaxel conjugate: Synthesis and preclinical evaluation by Machulkin, Aleksei E., Uspenskaya, Anastasia A., Zyk, Nikolay Y., Nimenko, Ekaterina A., Ber, Anton P., Petrov, Stanislav A., Shafikov, Radik R., Skvortsov, Dmitry A., Smirnova, Galina B., Borisova, Yulia A., Pokrovsky, Vadim S., Kolmogorov, Vasilii S., Vaneev, Alexander N., Ivanenkov, Yan A., Khudyakov, Alexander D., Kovalev, Sergei V., Erofeev, Alexander S., Gorelkin, Petr V., Beloglazkina, Elena K., Zyk, Nikolay V., Khazanova, Elena S., Majouga, Alexander G.

“…Prostate cancer is one of the most commonly diagnosed men's cancers and remains one of the leading causes of cancer death. The development of approaches to the…”
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Synthesis, [sup.123]I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures by Hasnowo, Lutfi A, Larkina, Maria S, Plotnikov, Evgenii, Bodenko, Vitalina, Yuldasheva, Feruza, Stasyuk, Elena, Petrov, Stanislav A, Zyk, Nikolai Y, Machulkin, Aleksei E, Vorozhtsov, Nikolai I, Beloglazkina, Elena K, Nenajdenko, Valentine G, Tolmachev, Vladimir, Orlova, Anna, Majouga, Alexander G, Yusubov, Mekhman S

“…Prostate-specific membrane antigen (PSMA) has been identified as a target for the development of theranostic agents. In our current work, we describe the…”
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Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with 177Lu by Machulkin, Aleksei E., Petrov, Stanislav A., Bodenko, Vitalina, Larkina, Mariia S., Plotnikov, Evgenii, Yuldasheva, Feruza, Tretyakova, Maria, Bezverkhniaia, Ekaterina, Zyk, Nikolay Yu, Stasyuk, Elena, Zelchan, Roman, Majouga, Alexander G., Tolmachev, Vladimir, Orlova, Anna, Beloglazkina, Elena K., Yusubov, Mekhman S.

“…177Lu-labeled small-molecule prostate-specific membrane antigen (PSMA) targeted tracers are therapeutic agents for metastatic castration-resistant prostate…”
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Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with 177 Lu by Machulkin, Aleksei E, Petrov, Stanislav A, Bodenko, Vitalina, Larkina, Mariia S, Plotnikov, Evgenii, Yuldasheva, Feruza, Tretyakova, Maria, Bezverkhniaia, Ekaterina, Zyk, Nikolay Yu, Stasyuk, Elena, Zelchan, Roman, Majouga, Alexander G, Tolmachev, Vladimir, Orlova, Anna, Beloglazkina, Elena K, Yusubov, Mekhman S

“…Lu-labeled small-molecule prostate-specific membrane antigen (PSMA) targeted tracers are therapeutic agents for metastatic castration-resistant prostate…”
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Synthesis and organogelating behaviour of urea- and Fmoc-containing diphenylalanine based hexaamide by Petrov, Stanislav A., Machulkin, Aleksei E., Petrov, Rostislav A., Tavtorkin, Alexander N., Bondarenko, Galina N., Legkov, Sergey A., Nifant'ev, Ilya E., Dolzhikova, Valentina D., Zyk, Nikolay V., Majouga, Alexander G., Beloglazkina, Elena K.

“…•A new hexaamide organоgelator with urea moiety was synthesized.•The gels form in DCM, CDCl3, MeOH, EtOAc, MeCN, MeCN/H2O.•Gel morphologies differ in DCM and…”
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Synthesis, I-123-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures by Hasnowo, Lutfi A., Larkina, Maria S., Plotnikov, Evgenii, Bodenko, Vitalina, Yuldasheva, Feruza, Stasyuk, Elena, Petrov, Stanislav A., Zyk, Nikolai Y., Machulkin, Aleksei E., Vorozhtsov, Nikolai I., Beloglazkina, Elena K., Nenajdenko, Valentine G., Tolmachev, Vladimir, Orlova, Anna, Majouga, Alexander G., Yusubov, Mekhman S.

“…Prostate-specific membrane antigen (PSMA) has been identified as a target for the development of theranostic agents. In our current work, we describe the…”
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Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation by Zyk, Nikolay Yu, Petrov, Stanislav A., Zavertkina, Maria V., Uspenskaya, Anastasia A., Krasnikov, Pavel A., Dashkova, Natalia S., Beloglazkina, Elena K., Majouga, Alexander G., Zyk, Nikolay V., Machulkin, Aleksei E.

“…[Display omitted] Two alternative synthetic schemes involving solid-phase peptide synthesis steps for the preparation of prostatic specific membrane antigen…”
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Synthesis, 123 I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures by Hasnowo, Lutfi A, Larkina, Maria S, Plotnikov, Evgenii, Bodenko, Vitalina, Yuldasheva, Feruza, Stasyuk, Elena, Petrov, Stanislav A, Zyk, Nikolai Y, Machulkin, Aleksei E, Vorozhtsov, Nikolai I, Beloglazkina, Elena K, Nenajdenko, Valentine G, Tolmachev, Vladimir, Orlova, Anna, Majouga, Alexander G, Yusubov, Mekhman S

“…Prostate-specific membrane antigen (PSMA) has been identified as a target for the development of theranostic agents. In our current work, we describe the…”
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