Search Results - "Machuca, Mayra A"

Helicobacter pylori chemoreceptor TlpC mediates chemotaxis to lactate by Machuca, Mayra A., Johnson, Kevin S., Liu, Yu C., Steer, David L., Ottemann, Karen M., Roujeinikova, Anna

“…It is recently appreciated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the dCACHE family, a structure with two PAS-like subdomains,…”
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Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides by Modak, Joyanta K, Modakh, Joyanta K, Liu, Yu C, Machuca, Mayra A, Supuran, Claudiu T, Roujeinikova, Anna

“…Periplasmic α-carbonic anhydrase of Helicobacter pylori (HpαCA), an oncogenic bacterium in the human stomach, is essential for its acclimation to low pH. It…”
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The crystal structure of the tandem-PAS sensing domain of Campylobacter jejuni chemoreceptor Tlp1 suggests indirect mechanism of ligand recognition by Machuca, Mayra A., Liu, Yu C., Beckham, Simone A., Gunzburg, Menachem J., Roujeinikova, Anna

“…Chemotaxis and motility play an important role in the colonisation of avian and human hosts by Campylobacter jejuni. Chemotactic recognition of extracellular…”
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Structure-Activity Relationship Study Reveals the Molecular Basis for Specific Sensing of Hydrophobic Amino Acids by the Campylobacter jejuni Chemoreceptor Tlp3 by Khan, Mohammad F, Machuca, Mayra A, Rahman, Mohammad M, Koç, Cengiz, Norton, Raymond S, Smith, Brian J, Roujeinikova, Anna

“…Chemotaxis is an important virulence factor of the foodborne pathogen . Inactivation of chemoreceptor Tlp3 reduces the ability of to invade human and chicken…”
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Preliminary X-ray crystallographic studies on the Helicobacter pylori ABC transporter glutamine-binding protein GlnH by Rahman, Mohammad M., Machuca, Mayra A., Roujeinikova, Anna

“…Periplasmic binding proteins (PBPs) of Gram-negative bacteria sense essential nutrients and mediate their uptake by ATP-binding cassette (ABC) transporters…”
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Purification, crystallization and preliminary X-ray crystallographic studies on the C-terminal domain of the flagellar protein FliL from Helicobacter pylori by Chan, Kar Lok, Machuca, Mayra A., Rahman, Mohammad Mizanur, Khan, Mohammad Firoz, Andrews, Daniel, Roujeinikova, Anna

“…FliL is an inner membrane protein, occupying a position between the rotor and the stator of the bacterial flagellar motor. Its proximity to, and interactions…”
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Bioinformatics analysis and biochemical characterisation of ABC transporter-associated periplasmic substrate-binding proteins ModA and MetQ from Helicobacter pylori strain SS1 by Rahman, Mohammad M., Machuca, Mayra A., Roujeinikova, Anna

“…The human gastric pathogen Helicobacter pylori relies on the uptake of host-provided nutrients for its proliferation and pathogenicity. ABC transporters that…”
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Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains by Liu, Yu C., Machuca, Mayra A., Beckham, Simone A., Gunzburg, Menachem J., Roujeinikova, Anna

“…Chemotaxis, mediated by methyl‐accepting chemotaxis protein (MCP) receptors, plays an important role in the ecology of bacterial populations. This paper…”
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Molecular Basis of Unexpected Specificity of ABC Transporter-Associated Substrate-Binding Protein DppA from Helicobacter pylori by Rahman, Mohammad M, Machuca, Mayra A, Khan, Mohammad F, Barlow, Christopher K, Schittenhelm, Ralf B, Roujeinikova, Anna

“…The gastric pathogen has limited ability to use carbohydrates as a carbon source, relying instead on exogenous amino acids and peptides. Uptake of certain…”
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Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain by Machuca, Mayra A, Roujeinikova, Anna

“…Identification of natural ligands of chemoreceptors and structural studies aimed at elucidation of the molecular basis of the ligand specificity can be greatly…”
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Cloning, expression, refolding, purification and preliminary crystallographic analysis of the sensory domain of the Campylobacter chemoreceptor for aspartate A (CcaA) by Machuca, Mayra A., Liu, Yu C., Roujeinikova, Anna

“…In Campylobacter jejuni, chemotaxis and motility have been identified as important virulence factors that are required for host colonization and invasion…”
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Cloning, refolding, purification and preliminary crystallographic analysis of the sensory domain of the Campylobacter chemoreceptor for multiple ligands (CcmL) by Machuca, Mayra A., Liu, Yu C., Beckham, Simone A., Roujeinikova, Anna

“…A periplasmic sensory domain of the Campylobacter jejuni chemoreceptor for multiple ligands (CcmL) has been crystallized by the hanging‐drop vapour‐diffusion…”
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Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain by Machuca, Mayra A., Roujeinikova, Anna

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Structural Basis for the Inhibition of Helicobacter pylori [alpha]-Carbonic Anhydrase by Sulfonamides by Modakh, Joyanta K, Liu, Yu C, Machuca, Mayra A, Supuran, Claudiu T, Roujeinikova, Anna

“…Periplasmic [alpha]-carbonic anhydrase of Helicobacter pylori (Hp[alpha]CA), an oncogenic bacterium in the human stomach, is essential for its acclimation to…”
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Structural Basis for the Inhibition of Helicobacter pylori alpha -Carbonic Anhydrase by Sulfonamides: e0127149 by Modakh, Joyanta K, Liu, Yu C, Machuca, Mayra A, Supuran, Claudiu T, Roujeinikova, Anna

“…Periplasmic alpha -carbonic anhydrase of Helicobacter pylori (Hp alpha CA), an oncogenic bacterium in the human stomach, is essential for its acclimation to…”
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