Search Results - "Machova, Polakova K."

Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia by Cross, N C P, White, H E, Colomer, D, Ehrencrona, H, Foroni, L, Gottardi, E, Lange, T, Lion, T, Machova Polakova, K, Dulucq, S, Martinelli, G, Oppliger Leibundgut, E, Pallisgaard, N, Barbany, G, Sacha, T, Talmaci, R, Izzo, B, Saglio, G, Pane, F, Müller, M C, Hochhaus, A

“…Treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors has advanced to a stage where many patients achieve very low or undetectable levels…”
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Unraveling the complexity of tyrosine kinase inhibitor–resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain by Soverini, Simona, De Benedittis, Caterina, Machova Polakova, K., Brouckova, Adela, Horner, David, Iacono, Michele, Castagnetti, Fausto, Gugliotta, Gabriele, Palandri, Francesca, Papayannidis, Cristina, Iacobucci, Ilaria, Venturi, Claudia, Bochicchio, Maria Teresa, Klamova, Hana, Cattina, Federica, Russo, Domenico, Bresciani, Paola, Binotto, Gianni, Giannini, Barbara, Kohlmann, Alexander, Haferlach, Torsten, Roller, Andreas, Rosti, Gianantonio, Cavo, Michele, Baccarani, Michele, Martinelli, Giovanni

“…In chronic myeloid leukemia and Philadelphia chromosome–positive acute lymphoblastic leukemia, tyrosine kinase inhibitor (TKI) therapy may select for…”
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Clinical impact of low-burden BCR-ABL1 mutations detectable by amplicon deep sequencing in Philadelphia-positive acute lymphoblastic leukemia patients by Soverini, S, De Benedittis, C, Papayannidis, C, Polakova, K Machova, Venturi, C, Russo, D, Bresciani, P, Iurlo, A, Mancini, M, Vitale, A, Chiaretti, S, Foà, R, Abruzzese, E, Sorà, F, Kohlmann, A, Haferlach, T, Baccarani, M, Cavo, M, Martinelli, G

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Proteomic analysis of imatinib-resistant CML-T1 cells reveals calcium homeostasis as a potential therapeutic target by Toman, O, Kabickova, T, Vit, O, Fiser, R, Polakova, K. Machova, Zach, J, Linhartova, J, Vyoral, D, Petrak, J

“…Chronic myeloid leukemia (CML) therapy has markedly improved patient prognosis after introduction of imatinib mesylate for clinical use. However, a subset of…”
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Evaluation of Czech spring malting barleys with respect to the β-amylase allele incidence by Ovesna, J, MachovaPolakova, K, Kucera, L, Vaculova, K, Milotova, J

“…Strong enzymatic activities in the germinating barley grain, together with protein and starch content, are crucial for high extraction values in the resulting…”
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Real-time PCR quantification of major Wilms’ tumor gene 1 (WT1) isoforms in acute myeloid leukemia, their characteristic expression patterns and possible functional consequences by Kramarzova, K, Stuchly, J, Willasch, A, Gruhn, B, Schwarz, J, Cermak, J, Machova-Polakova, K, Fuchs, O, Stary, J, Trka, J, Boublikova, L

“…Wilms’ tumor gene 1 ( WT1 ) functions including some contradictory effects may be explained by the presence and interactions of its isoforms, however, their…”
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S154: IMATINIB‐RESISTANT CLONES ISOLATED FROM A MODEL OF BLAST CRISIS OF CHRONIC MYELOID LEUKAEMIA DIFFER IN MUTATIONS IN BCR::ABL1 AND OTHER CANCER RELATED GENES AND IN THEIR SENSITIVITY TO BH3‐MIMETICS by Laznicka, A., Curik, N., Polivkova, V., Koblihova, J., Burda, P., Dolnikova, A., Pokorna, E., Salek, C., Klamova, H., Srbova, D., Klener, P., Machova Polakova, K.

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Dasatinib in imatinib-resistant or -intolerant CML patients: data from the clinical practice of 6 hematological centers in the Czech Republic by Klamova, H, Faber, E, Zackova, D, Markova, M, Voglova, J, Cmunt, E, Novakova, L, Machova-Polakova, K, Moravcova, J, Dvorakova, D, Michalova, K, Brezinova, J, Oltova, A, Jarosova, M, Cetkovsky, P, Indrak, K, Mayer, J

“…Dasatinib is effective second line treatment for patients with chronic myeloid leukemia (CML) resistant or intolerant to imatinib. We report here the first…”
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Coding region single nucleotide polymorphism in the barley low-pI, alpha-amylase gene Amy32b by Polakova, K Machova, Kucera, L, Laurie, D A, Vaculova, K, Ovesna, J

“…Barley alpha-amylase variability influences the quality of barley grain in the brewing, feed and food industries. alpha-Amylase proteins are encoded by…”
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Abstract 951: Role of the MSC-derived exosomal and endogenous JAK2-SET/PP2A-β-catenin-modulator miR-300 in leukemic stem/progenitor proliferation and survival in CML by Trotta, Rossana, Silvestri, Giovannino, Stramucci, Lorenzo, Ellis, Justin J., Yu, Justine, Harb, Jason J., Neviani, Paolo, Marcucci, Guido, Srutova, Klara, Machova, Polakova K., Roy, Denis-Claude, Hokland, Peter, Deininger, Michael, Bhatia, Ravi, Gambacorti-Passerini, Carlo, Milojkovic, Dragana, Reid, Alistair, Apperley, Jane, Livak, Ferenc, Qi, Jianfei, Baer, Maria R., Perrotti, Danilo

“…Abstract MiR-300 is a microRNA predicted to target multiple components of the BCR-ABL1/JAK2/hnRNPA1/SET/PP2A/β-catenin pathway, which is essential for…”
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CHRONIC MYELOID LEUKEMIA PATIENTS WERE NOT DIFFERENT IN MOLECULAR RELAPSE AFTER STOPPING IMATINIB IN MR4 WHETHER RESIDUAL DISEASE WAS DETECTED OR NOT - WHEN ADJUSTING FOR NUMBER OF CONTROL TRANSCRIPTS by Pfirrmann, M., Mahon, F-X, Guilhot, J., Richter, J., Almeida, A., Janssen, J. J., Mayer, J., Koskenvesa, P., Panayiotidis, P., Strömberg, Ulla Ohlsson, Berger, M. G., Diamond, J., Ehrencrona, H., Kairisto, V., Polakova, K. Machova, Mueller, M. C., Mustjoki, S., Hochhaus, A., Saussele, S., Hjorth-Hansen, H.

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Stopping Tyrosine Kinase Inhibitors In A Very Large Cohort Of European Chronic Myeloid Leukemia Patients: Results Of The Euro-Ski Trial by Richter, J., Mahon, F. X., Guilhot, J., Hjorth-Hansen, H., Almeida, A., Janssen, J. J., Mayer, J., Porkka, K., Panayiotidis, P., Olsson-Strömberg, Ulla, Berger, M. G., Diamond, J., Ehrencrona, H., Kairisto, V., Polakova, K. Machova, Muller, M. C., Mustjoki, S., Hochhaus, A., Pfirrmann, M., Saussele, S.

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PF414 DNA‐BASED BCR‐ABL1 ANALYSIS PROVIDES A “TRAFFIC LIGHT” STRATIFICATION MODEL FOR CHRONIC MYELOID LEUKEMIA WITH IMPLICATIONS FOR TREATMENT FREE REMISSION by Machova Polakova, K., Zizkova, H., Zuna, J., Motlova, E., Hovorkova, L., Pecherkova, P., Klamova, H., Stastna Markova, M., Srbova, D., Koblihova, J., Benesova, A., Polivkova, V., Jurcek, T., Zackova, D., Mayer, J., Ernst, T., Mahon, F.X., Saussele, S., Cross, N.C., Hochhaus, A.

“…Background: Treatment free remission (TFR) or molecular relapse free survival (MRFS) have become important therapeutic aims for patients with chronic myeloid…”
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Coding region single nucleotide polymorphism in the barley low-pI, [alpha]-amylase gene Amy32b by Polakova, K Machova, Kucera, L, Laurie, D A, Vaculova, K, Ovesna, J

“…Barley α-amylase variability influences the quality of barley grain in the brewing, feed and food industries. α-Amylase proteins are encoded by multigene…”
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Coding region single nucleotide polymorphism in the barley low-pl, α-amylase gene Amy32b by Polakova, K.M, Kucera, L, Laurie, D.A, Vaculova, K, Ovesna, J

“…Barley alpha-amylase variability influences the quality of barley grain in the brewing, feed and food industries. alpha-Amylase proteins are encoded by…”
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