Search Results - "Machin, Samuel"

Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies by Scully, Marie, Hunt, Beverley J., Benjamin, Sylvia, Liesner, Ri, Rose, Peter, Peyvandi, Flora, Cheung, Betty, Machin, Samuel J.

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Performance evaluation of the Sysmex haematology XN modular system by Briggs, Carol, Longair, Ian, Kumar, Punamar, Singh, Deepak, Machin, Samuel J

“…The Sysmex XN haematology instrument performs automatic reflex testing, depending on sample results. A nucleated red blood cell (NRBC) count is provided on all…”
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A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpura by Scully, Marie, McDonald, Vickie, Cavenagh, Jamie, Hunt, Beverley J., Longair, Ian, Cohen, Hannah, Machin, Samuel J.

“…The safety and efficacy of weekly rituximab 375 mg/m2 (×4), given within 3 days of acute TTP admission, with standard therapy (PEX and steroids) was evaluated…”
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Rivaroxaban versus warfarin to treat patients with thrombotic antiphospholipid syndrome, with or without systemic lupus erythematosus (RAPS): a randomised, controlled, open-label, phase 2/3, non-inferiority trial by Cohen, Hannah, Dr, Hunt, Beverley J, Prof, Efthymiou, Maria, PhD, Arachchillage, Deepa R J, MD, Mackie, Ian J, PhD, Clawson, Simon, BSc, Sylvestre, Yvonne, MSc, Machin, Samuel J, Prof, Bertolaccini, Maria L, PhD, Ruiz-Castellano, Maria, MD, Muirhead, Nicola, PhD, Doré, Caroline J, Prof, Khamashta, Munther, Prof, Isenberg, David A, Prof

“…Summary Background Rivaroxaban is established for the treatment and secondary prevention of venous thromboembolism, but whether it is useful in patients with…”
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Remission in acute refractory and relapsing thrombotic thrombocytopenic purpura following rituximab is associated with a reduction in IgG antibodies to ADAMTS‐13 by Scully, Marie, Cohen, Hannah, Cavenagh, Jamie, Benjamin, Sylvia, Starke, Richard, Killick, Sally, Mackie, Ian, Machin, Samuel J.

“…Summary Thrombotic thrombocytopenic purpura (TTP) is a life‐threatening disorder and plasma exchange (PEX) remains the primary treatment modality. Twenty‐five…”
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Diagnosis and management of non-criteria obstetric antiphospholipid syndrome by Arachchillage, Deepa R Jayakody, Machin, Samuel J, Mackie, Ian J, Cohen, Hannah

“…Accurate diagnosis of obstetric antiphospholipid syndrome (APS) is a prerequisite for optimal clinical management. The international consensus (revised…”
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Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura by Westwood, John‐Paul, Langley, Kathryn, Heelas, Edward, Machin, Samuel J., Scully, Marie

“…Summary Complement dysregulation is key in the pathogenesis of atypical Haemolytic Uraemic Syndrome (aHUS), but no clear role for complement has been…”
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A performance evaluation of chemiluminescence enzyme immunoassays on the Sysmex CN‐6500 haemostasis analyser by Gardiner, Chris, Lane, Philip, Tailor, Hitesh, Machin, Samuel J., Mackie, Ian J.

“…Background The Sysmex CN‐6500 is a new haemostasis analyser with an integrated immunoassay module that performs chemiluminescence enzyme assay (CLEIA) in…”
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Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia by Briggs, Carol, Kunka, Stefan, Hart, Dan, Oguni, Shinichiro, Machin, Samuel J.

“…Summary A new automated method to reliably quantify reticulated platelets, expressed as the immature platelet fraction (IPF), has been developed utilizing the…”
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Platelets: the few, the young, and the active by D'Souza, Carol, Briggs, Carol, Machin, Samuel J

“…Many modern automated cell counters in high-volume clinical hematology laboratories use new, improved technologies for routine platelet analysis. The latest…”
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A comparative evaluation of the CN‐6000 haemostasis analyser using coagulation, amidolytic, immuno‐turbidometric and light transmission aggregometry assays by Gardiner, Chris, Lane, Philip, Langley, Katy, Tailor, Hitesh, Machin, Samuel J., Mackie, Ian J.

“…Background The CN‐6000 (Sysmex Corp.) is a new haemostasis analyser with blood coagulation, amidolytic, immuno‐turbidometric and light transmission…”
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Managing anticoagulated patients during neuraxial anaesthesia by Green, Laura, Machin, Samuel J.

“…Summary The widespread use of central neuraxial block (CNB) and the prevalence of anticoagulation for different indications have led to an inevitable overlap…”
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Feasibility of a mean platelet volume standard: an international council for standardization in hematology (ICSH) inter-laboratory study by Harrison, Paul, Price, Joshua, Didembourg, Marie, Johnson, Alan, Baldwin, Samuel, Veronneau, Marcel, Baertlein, Daniel, Shi, Xiaoyong, Machin, Samuel

“…We have evaluated a commercial-fixed porcine platelet preparation (with and without added fixed human red blood cells (RBC)) for the potential standardization…”
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Carol Briggs (1958-2015) by Machin, Samuel J.

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Improved Flagging Rates on the Sysmex XE-5000 Compared With the XE-2100 Reduce the Number of Manual Film Reviews and Increase Laboratory Productivity by BRIGGS, Carol J, LINSSEN, Joachim, LONGAIR, Ian, MACHIN, Samuel J

“…Hematology analyzers generate suspect flags in the presence of abnormal cells. False-positive rates for flags are high on all analyzers. Sysmex, Kobe, Japan,…”
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The value of the white precursor cell channel (WPC) on the Sysmex XN-1000 analyser in a specialist paediatric hospital by Jones, Amanda S, Tailor, Hitesh, Liesner, Ri, Machin, Samuel J, Briggs, Carol J

“…Historically, haematology analyser flags for abnormal white blood cells (WBCs) show good sensitivity but lower specificity, causing unnecessary blood film…”
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Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias by Allford, Sarah L., Hunt, Beverley J., Rose, Peter, Machin, Samuel J.

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Initial experience from a double-blind, placebo-controlled, clinical outcome study of ARC1779 in patients with thrombotic thrombocytopenic purpura by Cataland, Spero R., Peyvandi, Flora, Mannucci, Pier M., Lämmle, Bernhard, Kremer Hovinga, Johanna A., Machin, Samuel J., Scully, Marie, Rock, Gail, Gilbert, James C., Yang, Shangbin, Wu, Haifeng, Jilma, Bernd, Knoebl, Paul

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Guidelines on fibrinogen assays by Mackie, Ian J., Kitchen, Steven, Machin, Samuel J., Lowe, Gordon D. O.

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Use of the complement inhibitor Coversin to treat HSCT-associated TMA by Goodship, Timothy H.J., Pinto, Fernando, Weston-Davies, Wynn H., Silva, Juliana, Nishimura, Jun-ichi, Nunn, Miles A., Mackie, Ian, Machin, Samuel J., Palm, Liina, Pryce, Jeremy W., Chiesa, Robert, Amrolia, Persis, Veys, Paul

“…•Finding an inherited complement abnormality in HSCT-associated TMA provides a rationale for the use of a complement inhibitor.•Alternative complement…”
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