Search Results - "Machida, Yuichi J"

DNA–protein crosslinks from environmental exposure: Mechanisms of formation and repair by Kojima, Yusuke, Machida, Yuichi J.

“…Many environmental carcinogens cause DNA damage, which can result in mutations and other alterations in genomic DNA if not repaired promptly. Because of the…”
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FAM111A protects replication forks from protein obstacles via its trypsin-like domain by Kojima, Yusuke, Machida, Yuka, Palani, Sowmiya, Caulfield, Thomas R., Radisky, Evette S., Kaufmann, Scott H., Machida, Yuichi J.

“…Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be…”
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The APC/C inhibitor, Emi1, is essential for prevention of rereplication by Machida, Yuichi J, Dutta, Anindya

“…Emi1 (early mitotic inhibitor) inhibits APC/C (anaphase-promoting complex/cyclosome) activity during S and G2 phases, and is believed to be required for proper…”
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The Deubiquitinating Enzyme BAP1 Regulates Cell Growth via Interaction with HCF-1 by Machida, Yuichi J., Machida, Yuka, Vashisht, Ajay A., Wohlschlegel, James A., Dutta, Anindya

“…The deubiquitinating enzyme BRCA1-associated protein 1 (BAP1) possesses growth inhibitory activity and functions as a tumor suppressor. In this study we report…”
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Spartan/C1orf124 is important to prevent UV-induced mutagenesis by Machida, Yuka, Kim, Myoung Shin, Machida, Yuichi J.

“…Uninterrupted replication across damaged DNA is critical to prevent replication fork collapse and resulting double-strand DNA breaks. Rad18-mediated PCNA…”
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Spartan deficiency causes genomic instability and progeroid phenotypes by Maskey, Reeja S., Kim, Myoung Shin, Baker, Darren J., Childs, Bennett, Malureanu, Liviu A., Jeganathan, Karthik B., Machida, Yuka, van Deursen, Jan M., Machida, Yuichi J.

“…Spartan (also known as DVC1 and C1orf124) is a PCNA-interacting protein implicated in translesion synthesis, a DNA damage tolerance process that allows the DNA…”
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Functions and evolution of FAM111 serine proteases by Welter, Allison L, Machida, Yuichi J

“…Proteolysis plays fundamental and regulatory roles in diverse cellular processes. The serine protease FAM111A (FAM111 trypsin-like peptidase A) emerged…”
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MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1 by Popay, Tessa M, Wang, Jing, Adams, Clare M, Howard, Gregory Caleb, Codreanu, Simona G, Sherrod, Stacy D, McLean, John A, Thomas, Lance R, Lorey, Shelly L, Machida, Yuichi J, Weissmiller, April M, Eischen, Christine M, Liu, Qi, Tansey, William P

“…The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer…”
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Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes by Palani, Sowmiya, Machida, Yuka, Alvey, Julia R., Mishra, Vandana, Welter, Allison L., Cui, Gaofeng, Bragantini , Benoît, Botuyan, Maria Victoria, Cong, Anh T. Q., Mer, Georges, Schellenberg, Matthew J., Machida, Yuichi J.

“…FAM111A, a serine protease, plays roles in DNA replication and antiviral defense. Missense mutations in the catalytic domain cause hyper-autocleavage and are…”
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Right Place, Right Time, and Only Once: Replication Initiation in Metazoans by Machida, Yuichi J., Hamlin, Joyce L., Dutta, Anindya

“…DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and checkpoint pathways. Here, we discuss recent advances in…”
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UBE2T Is the E2 in the Fanconi Anemia Pathway and Undergoes Negative Autoregulation by Machida, Yuichi J., Machida, Yuka, Chen, Yuefeng, Gurtan, Allan M., Kupfer, Gary M., D'Andrea, Alan D., Dutta, Anindya

“…The Fanconi anemia pathway is required for the efficient repair of damaged DNA. A key step in this pathway is the monoubiquitination of the FANCD2 protein by…”
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Regulation of error-prone translesion synthesis by Spartan/C1orf124 by Kim, Myoung Shin, Machida, Yuka, Vashisht, Ajay A, Wohlschlegel, James A, Pang, Yuan-Ping, Machida, Yuichi J

“…Translesion synthesis (TLS) employs low fidelity polymerases to replicate past damaged DNA in a potentially error-prone process. Regulatory mechanisms that…”
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UBE2T, the Fanconi Anemia Core Complex, and FANCD2 Are Recruited Independently to Chromatin: a Basis for the Regulation of FANCD2 Monoubiquitination by Alpi, Arno, Langevin, Frederic, Mosedale, Georgina, Machida, Yuichi J., Dutta, Anindya, Patel, Ketan J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Human KIAA1018/FAN1 localizes to stalled replication forks via its ubiquitin-binding domain by Shereda, Robert D., Machida, Yuka, Machida, Yuichi J.

“…Genome maintenance pathways correct aberrations in DNA that would be deleterious to the organism.  A crucial element of many genome maintenance processes is…”
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Acute Reduction of an Origin Recognition Complex (ORC) Subunit in Human Cells Reveals a Requirement of ORC for Cdk2 Activation by Machida, Yuichi J., Teer, Jamie K., Dutta, Anindya

“…The origin recognition complex (ORC) is involved in formation of prereplicative complexes (pre-RCs) on replication origins in the G1 phase. At the G1/S…”
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BRCA1-associated Protein 1 (BAP1) Deubiquitinase Antagonizes the Ubiquitin-mediated Activation of FoxK2 Target Genes by Okino, Yuki, Machida, Yuka, Frankland-Searby, Sarah, Machida, Yuichi J.

“…BRCA1-associated protein 1 (BAP1), which is frequently mutated in cancer, functions as a deubiquitinase (DUB) for histone H2A. Although BAP1 interacts with a…”
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Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway by Kurmi, Kiran, Hitosugi, Sadae, Yu, Jia, Boakye-Agyeman, Felix, Wiese, Elizabeth K., Larson, Thomas R., Dai, Qing, Machida, Yuichi J., Lou, Zhenkun, Wang, Liewei, Boughey, Judy C., Kaufmann, Scott H., Goetz, Matthew P., Karnitz, Larry M., Hitosugi, Taro

“…How mitochondrial metabolism is altered by oncogenic tyrosine kinases to promote tumor growth is incompletely understood. Here, we show that oncogenic HER2…”
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Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis by Maskey, Reeja S, Flatten, Karen S, Sieben, Cynthia J, Peterson, Kevin L, Baker, Darren J, Nam, Hyun-Ja, Kim, Myoung Shin, Smyrk, Thomas C, Kojima, Yusuke, Machida, Yuka, Santiago, Annyoceli, van Deursen, Jan M, Kaufmann, Scott H, Machida, Yuichi J

“…Germline mutations in SPRTN cause Ruijs-Aalfs syndrome (RJALS), a disorder characterized by genome instability, progeria and early onset hepatocellular…”
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A mechanism for the tissue specificity in BAP1 cancer syndrome by Machida, Yuichi J

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Cellular Checkpoint Mechanisms Monitoring Proper Initiation of DNA Replication by Machida, Yuichi J., Dutta, Anindya

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