Search Results - "Machelska, Halina"

Modulation of peripheral sensory neurons by the immune system: implications for pain therapy by Stein, Christoph, Machelska, Halina

“…The concept that the immune system can communicate with peripheral sensory neurons to modulate pain is based mostly on documented interactions between opioid…”
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Opioid Receptors in Immune and Glial Cells-Implications for Pain Control by Machelska, Halina, Celik, Melih Ö

“…Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas…”
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Advances in Achieving Opioid Analgesia Without Side Effects by Machelska, Halina, Celik, Melih Ö

“…Opioids are the most effective drugs for the treatment of severe pain, but they also cause addiction and overdose deaths, which have led to a worldwide opioid…”
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A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors by Baamonde, Ana, Menéndez, Luis, González-Rodríguez, Sara, Lastra, Ana, Seitz, Viola, Stein, Christoph, Machelska, Halina

“…The newly designed fentanyl derivative [( ±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide] (NFEPP) was recently shown to produce analgesia…”
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Amelioration of injury-induced tissue acidosis by a nonsteroidal analgesic attenuates antinociceptive effects of the pH-dependent opioid agonist NFEPP by Celik, Melih Ö., Negrete, Roger, Di Rosso, Riccardo, Machelska, Halina, Stein, Christoph

“…Opioid agonists are powerful drugs for managing pain. However, their central side effects are limiting their use and drugs with similar potency, but a lower…”
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pKa of opioid ligands as a discriminating factor for side effects by Del Vecchio, Giovanna, Labuz, Dominika, Temp, Julia, Seitz, Viola, Kloner, Michael, Negrete, Roger, Rodriguez-Gaztelumendi, Antonio, Weber, Marcus, Machelska, Halina, Stein, Christoph

“…The non-selective activation of central and peripheral opioid receptors is a major shortcoming of currently available opioids. Targeting peripheral opioid…”
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Dual Peripheral Actions of Immune Cells in Neuropathic Pain by Machelska, Halina

“…Ability to perceive physiological pain is essential in protecting the individual from tissue destruction. In contrast, pathological chronic pain is an…”
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μ-Opioid receptor antibody reveals tissue-dependent specific staining and increased neuronal μ-receptor immunoreactivity at the injured nerve trunk in mice by Schmidt, Yvonne, Gavériaux-Ruff, Claire, Machelska, Halina

“…Neuropathic pain is a debilitating chronic disease often resulting from damage to peripheral nerves. Activation of opioid receptors on peripheral sensory…”
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Attacking pain at its source: new perspectives on opioids by Stein, Christoph, Schäfer, Michael, Machelska, Halina

“…The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including…”
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Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models by Schäfer, Marjann, Reisch, Florian, Labuz, Dominika, Machelska, Halina, Stehling, Sabine, Püschel, Gerhard P, Rothe, Michael, Heydeck, Dagmar, Kuhn, Hartmut

“…Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in the pathogenesis of inflammatory diseases, and its pro- and anti-inflammatory effects…”
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Polyglycerol-opioid conjugate produces analgesia devoid of side effects by González-Rodríguez, Sara, Quadir, Mohiuddin A, Gupta, Shilpi, Walker, Karolina A, Zhang, Xuejiao, Spahn, Viola, Labuz, Dominika, Rodriguez-Gaztelumendi, Antonio, Schmelz, Martin, Joseph, Jan, Parr, Maria K, Machelska, Halina, Haag, Rainer, Stein, Christoph

“…Novel painkillers are urgently needed. The activation of opioid receptors in peripheral inflamed tissue can reduce pain without central adverse effects such as…”
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Recent advances in understanding neuropathic pain: glia, sex differences, and epigenetics [version 1; peer review: 2 approved] by Machelska, Halina, Celik, Melih Ö

“…Neuropathic pain results from diseases or trauma affecting the nervous system. This pain can be devastating and is poorly controlled. The pathophysiology is…”
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Control of neuropathic pain by immune cells and opioids by Machelska, Halina

“…Neuropathic pain is a compilation of somatosensory, cognitive and emotional alterations developing following nerve injuries. Such pain often outlasts the…”
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A stomatin-domain protein essential for touch sensation in the mouse by Wetzel, Christiane, Kozlenkov, Alexey, Eilers, Andreas, Heppenstall, Paul A, Riethmacher, Dieter, Harder, Lena, Caspani, Ombretta, Machelska, Halina, Erdmann, Bettina, Hu, Jing, Benckendorff, Anne, Labuz, Dominika, Moshourab, Rabih, Lewin, Gary R

“…Touch and mechanical pain are first detected at our largest sensory surface, the skin. The cell bodies of sensory neurons that detect such stimuli are located…”
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Author Correction: pKa of opioid ligands as a discriminating factor for side effects by Del Vecchio, Giovanna, Labuz, Dominika, Temp, Julia, Seitz, Viola, Kloner, Michael, Negrete, Roger, Rodriguez-Gaztelumendi, Antonio, Weber, Marcus, Machelska, Halina, Stein, Christoph

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Mu-Opioid Receptor Agonist Induces Kir3 Currents in Mouse Peripheral Sensory Neurons - Effects of Nerve Injury by Stötzner, Philip, Spahn, Viola, Celik, Melih Ö, Labuz, Dominika, Machelska, Halina

“…Neuropathic pain often arises from damage to peripheral nerves and is difficult to treat. Activation of opioid receptors in peripheral sensory neurons is…”
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Relative contribution of peripheral versus central opioid receptors to antinociception by Labuz, Dominika, Mousa, Shaaban A, Schäfer, Michael, Stein, Christoph, Machelska, Halina

“…Abstract Opioid effects are mediated by central and peripheral opioid receptors. Here we examine the relative contribution of each receptor population to…”
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Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5−/− Mice by Marbach-Breitrück, Eugenia, Rohwer, Nadine, Infante-Duarte, Carmen, Romero-Suarez, Silvina, Labuz, Dominika, Machelska, Halina, Kutzner, Laura, Schebb, Nils Helge, Rothe, Michael, Reddanna, Pallu, Weylandt, Karsten H., Wieler, Lothar H., Heydeck, Dagmar, Kuhn, Hartmut

“…Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes. We recently created knock-in mice (Alox5-KI)…”
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Leukocyte-derived opioid peptides and inhibition of pain by Machelska, Halina, Stein, Christoph

“…In peripheral inflamed tissue interactions between leukocyte-derived opioid peptides and opioid receptors on sensory neurons lead to potent, clinically…”
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Cutaneous Nociceptors Lack Sensitisation, but Reveal μ-Opioid Receptor-Mediated Reduction in Excitability to Mechanical Stimulation in Neuropathy by Schmidt, Yvonne, Labuz, Dominika, Heppenstall, Paul A, Machelska, Halina

“…Background: Peripheral nerve injuries often trigger a hypersensitivity to tactile stimulation. Behavioural studies demonstrated efficient and side effect-free…”
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